ES445592A1 - Prostenoic acid derivatives - Google Patents
Prostenoic acid derivativesInfo
- Publication number
- ES445592A1 ES445592A1 ES445592A ES445592A ES445592A1 ES 445592 A1 ES445592 A1 ES 445592A1 ES 445592 A ES445592 A ES 445592A ES 445592 A ES445592 A ES 445592A ES 445592 A1 ES445592 A1 ES 445592A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- compound
- reaction
- formula
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NNOJWZIBHANBJD-OALUTQOASA-N 7-[(1S,2S)-2-octylcyclopentyl]hept-2-enoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCC=CC(O)=O NNOJWZIBHANBJD-OALUTQOASA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 13
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- -1 alkali metal salts Chemical class 0.000 abstract 2
- 150000003863 ammonium salts Chemical class 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining a compound of general formula I **(See formula)** where A is -CO- or -CHOH-, B is -CH2-, -CH2, CH2- or -CH2O-, R1 is H or C 1-4 -alkyl, R2 is H, methyl or ethyl, and R3 means phenyl, or phenyl substituted one to three times by F, C1, CF3, OH, OCH3, OC2H5 or alkyl with 1 to 3 carbon atoms, and their physiologically compatible metal and ammonium salts, characterized in that a compound of general formula II **(See formula)** where Q1 means -B-R3 or R2, and B, R1, R2 and R3 have the meanings indicated above and the wavy line (see formula) means that the OH group can be in the α or β position or its alkali metal salts, are reacted with a compound of general formula III **(See formula)** where Q2 means methyl or ethyl (in case of Q1 = -B-R3) or -B-R3 (in case of Q1 = R2), M means Li, MgCl, -MgBr or MgI, and B, R2 and R3 have the meanings indicated above, or because a compound of general formula IV **(See formula)** where B, -R1 and R3 have the meanings indicated above, or one of its alkali metal salts, it is reacted with a reducing agent, or because in a compound that otherwise corresponds to the general formula I, in the whereas, however, the existing COOR1 and/or hydroxy and/or carbonyl groups are present in functionally modified form, the COOR1 and/or hydroxy and/or carbonyl groups are released by reaction with a solvolizing medium, and/or because, in optionally, a compound of general formula I, where A means -CHOH-, is transformed by reaction with an oxidizing agent into another compound of general formula I, where A means -C0-, and/or a compound of general formula I, where R1 is hydrogen, by reaction with an esterifying agent it is transformed into another compound of general formula I, where R1 is alkyl with 1 to 4 carbon atoms, and/or, a compound of general formula I, where R1 is alkyl with 1 to 4 carbon atoms, by reaction with an agen The solvolizing agent is transformed into another compound of general formula I and/or a compound of general formula 1 dissociates into its racemates and/or enantiomers, and/or, a compound of general formula I, by reaction with a base, is transformed into its physiologically compatible metal or ammonium salts, and/or, by reaction with an acid, is liberated from one of its salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752508995 DE2508995A1 (en) | 1975-03-01 | 1975-03-01 | PROSTANIC ACID DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES445592A1 true ES445592A1 (en) | 1977-06-01 |
Family
ID=5940216
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES445592A Expired ES445592A1 (en) | 1975-03-01 | 1976-02-27 | Prostenoic acid derivatives |
| ES458021A Expired ES458021A1 (en) | 1975-03-01 | 1977-04-21 | Prostenoic acid derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES458021A Expired ES458021A1 (en) | 1975-03-01 | 1977-04-21 | Prostenoic acid derivatives |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS51113847A (en) |
| AU (1) | AU496915B2 (en) |
| BE (1) | BE838987A (en) |
| CS (1) | CS189753B2 (en) |
| DD (1) | DD123450A5 (en) |
| DE (1) | DE2508995A1 (en) |
| DK (1) | DK85976A (en) |
| ES (2) | ES445592A1 (en) |
| FR (1) | FR2302727A1 (en) |
| GB (1) | GB1535373A (en) |
| IL (1) | IL49116A0 (en) |
| LU (1) | LU74449A1 (en) |
| NL (1) | NL7602107A (en) |
| SE (1) | SE7602743L (en) |
| ZA (1) | ZA761183B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE43462B1 (en) * | 1975-06-23 | 1981-03-11 | Pfizer | Substituted tetranorprostaglandins |
| EP1114816A4 (en) * | 1998-09-14 | 2002-09-04 | Ono Pharmaceutical Co | $g(v)-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT |
-
1975
- 1975-03-01 DE DE19752508995 patent/DE2508995A1/en active Pending
-
1976
- 1976-02-23 CS CS761181A patent/CS189753B2/en unknown
- 1976-02-25 AU AU11423/76A patent/AU496915B2/en not_active Expired
- 1976-02-26 BE BE4000788A patent/BE838987A/en unknown
- 1976-02-26 FR FR7605363A patent/FR2302727A1/en not_active Withdrawn
- 1976-02-27 IL IL49116A patent/IL49116A0/en unknown
- 1976-02-27 LU LU74449A patent/LU74449A1/xx unknown
- 1976-02-27 ZA ZA761183A patent/ZA761183B/en unknown
- 1976-02-27 ES ES445592A patent/ES445592A1/en not_active Expired
- 1976-02-27 DK DK85976*#A patent/DK85976A/en unknown
- 1976-02-27 DD DD191614A patent/DD123450A5/xx unknown
- 1976-02-27 SE SE7602743A patent/SE7602743L/en unknown
- 1976-02-27 GB GB7832/76A patent/GB1535373A/en not_active Expired
- 1976-03-01 JP JP51022591A patent/JPS51113847A/en active Pending
- 1976-03-01 NL NL7602107A patent/NL7602107A/en not_active Application Discontinuation
-
1977
- 1977-04-21 ES ES458021A patent/ES458021A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU1142376A (en) | 1977-09-01 |
| ZA761183B (en) | 1977-02-23 |
| JPS51113847A (en) | 1976-10-07 |
| BE838987A (en) | 1976-08-26 |
| IL49116A0 (en) | 1976-04-30 |
| NL7602107A (en) | 1976-09-03 |
| FR2302727A1 (en) | 1976-10-01 |
| LU74449A1 (en) | 1977-09-12 |
| DK85976A (en) | 1976-09-02 |
| CS189753B2 (en) | 1979-04-30 |
| AU496915B2 (en) | 1978-11-09 |
| ES458021A1 (en) | 1978-03-16 |
| DE2508995A1 (en) | 1976-09-09 |
| GB1535373A (en) | 1978-12-13 |
| SE7602743L (en) | 1976-09-02 |
| DD123450A5 (en) | 1976-12-20 |
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