ES444667A1 - A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A process for the preparation of new imidazole derivatives of the formula: ** (see formula) ** Or therapeutically acceptable acid addition salts and stereochemical optical isomeric forms thereof, wherein ar is phenyl, substituted phenyl, thienyl, halothienyl or naphthyl and wherein said substituted phenyl means a phenyl group containing 1 to 3 substituents independently selected from halogen, lower alkyl, lower alkyloxy, nitro or cyano and R is alkyl of 2 to 10 carbon atoms, alkyloxymethyl where the alkyl group contains 1 to 10 carbon atoms, alkenyl, alkenyloxymethyl where the alkenyl group contains 2 to 10 carbon atoms, 2-propynyloxymethyl, hydroxymethyl, halomethyl, aryl, arylalkyl (lower), aryloxymethyl, arylthiomethyl or arylmethoxymethyl, wherein said aryl is a member selected from the group consisting of phenyl, substituted phenyl, naphthyl, monohalonaphthyl and dihalonaphthyl and wherein said substituted phenyl means a phenyl group containing from 1 to 3 substituents independently selected from the group consisting of halogen, lower alkyl, lower alkyloxy, cyano, nitro, phenyl, phenylmethyl, benzoyl, halobenzoyl, lower alkylcarbonyl, lower alkyloxycarbonyl or trifluoromethyl, with the proviso that when there is more than one substituent, only one of them can be selected from the group consisting of phenyl, phenylmethyl, benzoyl and halobenzoic the; whose procedure is characterized by A) reacting, preferably at elevated temperatures, a compound of formula ** (see formula) ** Or a metal salt of said compound ii with a compound of formula ** (see formula) ** Where w is a reactive ester function, in an appropriate organic solvent, preferably in the presence of a metal iodide and, when the compound ii is used in the reaction without prior formation of salt, preferably using an excess of imidazole or adding an appropriate base for combine the acid that is released; B) optionally preparing acid addition salts of the therapeutically useful product obtained in the previous step, by reaction with an appropriate acid and further, if desired, preparing the stereochemical optical isomeric forms of the product obtained in the previous step. (Machine-translation by Google Translate, not legally binding)