ES444667A1 - A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES444667A1
ES444667A1 ES444667A ES444667A ES444667A1 ES 444667 A1 ES444667 A1 ES 444667A1 ES 444667 A ES444667 A ES 444667A ES 444667 A ES444667 A ES 444667A ES 444667 A1 ES444667 A1 ES 444667A1
Authority
ES
Spain
Prior art keywords
phenyl
formula
compound
group
substituted phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES444667A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/544,157 external-priority patent/US3936470A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES444667A1 publication Critical patent/ES444667A1/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process for the preparation of new imidazole derivatives of the formula: ** (see formula) ** Or therapeutically acceptable acid addition salts and stereochemical optical isomeric forms thereof, wherein ar is phenyl, substituted phenyl, thienyl, halothienyl or naphthyl and wherein said substituted phenyl means a phenyl group containing 1 to 3 substituents independently selected from halogen, lower alkyl, lower alkyloxy, nitro or cyano and R is alkyl of 2 to 10 carbon atoms, alkyloxymethyl where the alkyl group contains 1 to 10 carbon atoms, alkenyl, alkenyloxymethyl where the alkenyl group contains 2 to 10 carbon atoms, 2-propynyloxymethyl, hydroxymethyl, halomethyl, aryl, arylalkyl (lower), aryloxymethyl, arylthiomethyl or arylmethoxymethyl, wherein said aryl is a member selected from the group consisting of phenyl, substituted phenyl, naphthyl, monohalonaphthyl and dihalonaphthyl and wherein said substituted phenyl means a phenyl group containing from 1 to 3 substituents independently selected from the group consisting of halogen, lower alkyl, lower alkyloxy, cyano, nitro, phenyl, phenylmethyl, benzoyl, halobenzoyl, lower alkylcarbonyl, lower alkyloxycarbonyl or trifluoromethyl, with the proviso that when there is more than one substituent, only one of them can be selected from the group consisting of phenyl, phenylmethyl, benzoyl and halobenzoic the; whose procedure is characterized by A) reacting, preferably at elevated temperatures, a compound of formula ** (see formula) ** Or a metal salt of said compound ii with a compound of formula ** (see formula) ** Where w is a reactive ester function, in an appropriate organic solvent, preferably in the presence of a metal iodide and, when the compound ii is used in the reaction without prior formation of salt, preferably using an excess of imidazole or adding an appropriate base for combine the acid that is released; B) optionally preparing acid addition salts of the therapeutically useful product obtained in the previous step, by reaction with an appropriate acid and further, if desired, preparing the stereochemical optical isomeric forms of the product obtained in the previous step. (Machine-translation by Google Translate, not legally binding)
ES444667A 1975-01-27 1976-01-27 A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding) Expired ES444667A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/544,157 US3936470A (en) 1975-01-27 1975-01-27 1,3-Dioxolan-2-ylmethylimidazoles
US61986375A 1975-10-06 1975-10-06

Publications (1)

Publication Number Publication Date
ES444667A1 true ES444667A1 (en) 1977-11-16

Family

ID=27067525

Family Applications (1)

Application Number Title Priority Date Filing Date
ES444667A Expired ES444667A1 (en) 1975-01-27 1976-01-27 A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding)

Country Status (14)

Country Link
CS (1) CS202001B2 (en)
DK (1) DK157300C (en)
ES (1) ES444667A1 (en)
FI (1) FI62081C (en)
HU (1) HU174593B (en)
IE (1) IE43157B1 (en)
IL (1) IL48902A (en)
MX (1) MX3143E (en)
NZ (1) NZ179231A (en)
PH (1) PH13605A (en)
PL (1) PL101460B1 (en)
PT (1) PT64741B (en)
SU (1) SU850006A3 (en)
YU (1) YU39956B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575999A (en) * 1968-08-19 1971-04-20 Janssen Pharmaceutica Nv Ketal derivatives of imidazole

Also Published As

Publication number Publication date
IE43157B1 (en) 1980-12-31
DK30276A (en) 1976-07-28
MX3143E (en) 1980-05-09
YU39956B (en) 1985-06-30
PT64741A (en) 1976-02-01
YU11276A (en) 1983-01-21
PH13605A (en) 1980-08-05
PL101460B1 (en) 1978-12-30
FI62081B (en) 1982-07-30
NZ179231A (en) 1978-03-06
CS202001B2 (en) 1980-12-31
IL48902A0 (en) 1976-03-31
DK157300C (en) 1990-05-07
SU850006A3 (en) 1981-07-23
FI62081C (en) 1982-11-10
DK157300B (en) 1989-12-04
HU174593B (en) 1980-02-28
IL48902A (en) 1979-10-31
PT64741B (en) 1978-01-04
FI760175A (en) 1976-07-28
IE43157L (en) 1976-07-27

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