ES444667A1 - A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES444667A1 ES444667A1 ES444667A ES444667A ES444667A1 ES 444667 A1 ES444667 A1 ES 444667A1 ES 444667 A ES444667 A ES 444667A ES 444667 A ES444667 A ES 444667A ES 444667 A1 ES444667 A1 ES 444667A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- formula
- compound
- group
- substituted phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A process for the preparation of new imidazole derivatives of the formula: ** (see formula) ** Or therapeutically acceptable acid addition salts and stereochemical optical isomeric forms thereof, wherein ar is phenyl, substituted phenyl, thienyl, halothienyl or naphthyl and wherein said substituted phenyl means a phenyl group containing 1 to 3 substituents independently selected from halogen, lower alkyl, lower alkyloxy, nitro or cyano and R is alkyl of 2 to 10 carbon atoms, alkyloxymethyl where the alkyl group contains 1 to 10 carbon atoms, alkenyl, alkenyloxymethyl where the alkenyl group contains 2 to 10 carbon atoms, 2-propynyloxymethyl, hydroxymethyl, halomethyl, aryl, arylalkyl (lower), aryloxymethyl, arylthiomethyl or arylmethoxymethyl, wherein said aryl is a member selected from the group consisting of phenyl, substituted phenyl, naphthyl, monohalonaphthyl and dihalonaphthyl and wherein said substituted phenyl means a phenyl group containing from 1 to 3 substituents independently selected from the group consisting of halogen, lower alkyl, lower alkyloxy, cyano, nitro, phenyl, phenylmethyl, benzoyl, halobenzoyl, lower alkylcarbonyl, lower alkyloxycarbonyl or trifluoromethyl, with the proviso that when there is more than one substituent, only one of them can be selected from the group consisting of phenyl, phenylmethyl, benzoyl and halobenzoic the; whose procedure is characterized by A) reacting, preferably at elevated temperatures, a compound of formula ** (see formula) ** Or a metal salt of said compound ii with a compound of formula ** (see formula) ** Where w is a reactive ester function, in an appropriate organic solvent, preferably in the presence of a metal iodide and, when the compound ii is used in the reaction without prior formation of salt, preferably using an excess of imidazole or adding an appropriate base for combine the acid that is released; B) optionally preparing acid addition salts of the therapeutically useful product obtained in the previous step, by reaction with an appropriate acid and further, if desired, preparing the stereochemical optical isomeric forms of the product obtained in the previous step. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/544,157 US3936470A (en) | 1975-01-27 | 1975-01-27 | 1,3-Dioxolan-2-ylmethylimidazoles |
US61986375A | 1975-10-06 | 1975-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES444667A1 true ES444667A1 (en) | 1977-11-16 |
Family
ID=27067525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES444667A Expired ES444667A1 (en) | 1975-01-27 | 1976-01-27 | A procedure for the preparation of new derivatives of imidazol. (Machine-translation by Google Translate, not legally binding) |
Country Status (14)
Country | Link |
---|---|
CS (1) | CS202001B2 (en) |
DK (1) | DK157300C (en) |
ES (1) | ES444667A1 (en) |
FI (1) | FI62081C (en) |
HU (1) | HU174593B (en) |
IE (1) | IE43157B1 (en) |
IL (1) | IL48902A (en) |
MX (1) | MX3143E (en) |
NZ (1) | NZ179231A (en) |
PH (1) | PH13605A (en) |
PL (1) | PL101460B1 (en) |
PT (1) | PT64741B (en) |
SU (1) | SU850006A3 (en) |
YU (1) | YU39956B (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3575999A (en) * | 1968-08-19 | 1971-04-20 | Janssen Pharmaceutica Nv | Ketal derivatives of imidazole |
-
1975
- 1975-11-12 NZ NZ17923175A patent/NZ179231A/en unknown
- 1975-12-03 MX MX46175U patent/MX3143E/en unknown
- 1975-12-29 PH PH17929A patent/PH13605A/en unknown
-
1976
- 1976-01-15 YU YU11276A patent/YU39956B/en unknown
- 1976-01-21 SU SU762312703A patent/SU850006A3/en active
- 1976-01-26 DK DK30276A patent/DK157300C/en not_active IP Right Cessation
- 1976-01-26 FI FI760175A patent/FI62081C/en not_active IP Right Cessation
- 1976-01-26 CS CS48576A patent/CS202001B2/en unknown
- 1976-01-26 HU HU76JA748A patent/HU174593B/en not_active IP Right Cessation
- 1976-01-26 IL IL48902A patent/IL48902A/en unknown
- 1976-01-26 PT PT6474176A patent/PT64741B/en unknown
- 1976-01-26 PL PL18681476A patent/PL101460B1/en unknown
- 1976-01-26 IE IE13976A patent/IE43157B1/en unknown
- 1976-01-27 ES ES444667A patent/ES444667A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IE43157B1 (en) | 1980-12-31 |
DK30276A (en) | 1976-07-28 |
MX3143E (en) | 1980-05-09 |
YU39956B (en) | 1985-06-30 |
PT64741A (en) | 1976-02-01 |
YU11276A (en) | 1983-01-21 |
PH13605A (en) | 1980-08-05 |
PL101460B1 (en) | 1978-12-30 |
FI62081B (en) | 1982-07-30 |
NZ179231A (en) | 1978-03-06 |
CS202001B2 (en) | 1980-12-31 |
IL48902A0 (en) | 1976-03-31 |
DK157300C (en) | 1990-05-07 |
SU850006A3 (en) | 1981-07-23 |
FI62081C (en) | 1982-11-10 |
DK157300B (en) | 1989-12-04 |
HU174593B (en) | 1980-02-28 |
IL48902A (en) | 1979-10-31 |
PT64741B (en) | 1978-01-04 |
FI760175A (en) | 1976-07-28 |
IE43157L (en) | 1976-07-27 |
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