ES442579A1 - Procedimiento para preparar formulaciones de 1-dopa en uni- dades de dosificacion con revestimiento enterico-efervescen-te. - Google Patents

Procedimiento para preparar formulaciones de 1-dopa en uni- dades de dosificacion con revestimiento enterico-efervescen-te.

Info

Publication number
ES442579A1
ES442579A1 ES442579A ES442579A ES442579A1 ES 442579 A1 ES442579 A1 ES 442579A1 ES 442579 A ES442579 A ES 442579A ES 442579 A ES442579 A ES 442579A ES 442579 A1 ES442579 A1 ES 442579A1
Authority
ES
Spain
Prior art keywords
enteric coated
same
effervescent
dopa
dopa formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442579A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interx Research Corp
Original Assignee
Interx Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interx Research Corp filed Critical Interx Research Corp
Publication of ES442579A1 publication Critical patent/ES442579A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento para preparar formulaciones de I-DOPA en unidades de dosificación con revestimiento entérico-efervescente, caracterizado porque en su realización comprende, en una primera etapa preparar una combinación pulverulante, según medios convencionales ya conocidos en el arte, formada por un componente activo seleccionado de L-DOPA o un derivado del mismo capaz de disociar y liberarL-DOPA in vivo, de la fórmula general **(Fórmula)** donde R y R1 significan simultáneamente los grupos hidroxilo acetiloxilo o pivaliloxilo, R2 representa hidrógeno, metilo, bencilo, pivaloloximetilo o un metal alcalino, de preferencia potasio, o bien, el grupo OR2 puede ser reemplazado por el radical -N-glicínico, cuando R y R1 significan acetiloxilo, X es un ácido farmacológicamente aceptable, de preferencia Hc1 o Hc1O4, o bien el grupo -XH puede esta substituido por clorhidrato de glicilo cuando R y R1 son acetiloxilo y R2 es hidrógeno o metilo, o bien puede esta substituido por el radical formilo.
ES442579A 1974-11-14 1975-11-13 Procedimiento para preparar formulaciones de 1-dopa en uni- dades de dosificacion con revestimiento enterico-efervescen-te. Expired ES442579A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49131304A JPS5157813A (en) 1974-11-14 1974-11-14 Ll dooba mataha sonojudotaiseizaino seiho

Publications (1)

Publication Number Publication Date
ES442579A1 true ES442579A1 (es) 1978-01-16

Family

ID=15054818

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442579A Expired ES442579A1 (es) 1974-11-14 1975-11-13 Procedimiento para preparar formulaciones de 1-dopa en uni- dades de dosificacion con revestimiento enterico-efervescen-te.

Country Status (10)

Country Link
US (1) US3961041A (es)
JP (1) JPS5157813A (es)
CA (1) CA1047928A (es)
DE (1) DE2551280A1 (es)
ES (1) ES442579A1 (es)
FR (1) FR2290912A1 (es)
GB (1) GB1485676A (es)
IT (1) IT1069069B (es)
NL (1) NL7513370A (es)
SE (1) SE7512740L (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147768A (en) * 1976-09-13 1979-04-03 Interx Research Corporation Enteric coated digoxin and therapeutic use thereof
JPS54138128A (en) * 1978-04-19 1979-10-26 Akiyama Jiyouzai Kk Double contrast medium for intestine
US4289751A (en) * 1979-06-29 1981-09-15 Merck & Co., Inc. Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof
FR2470599A1 (fr) * 1979-12-07 1981-06-12 Panoz Donald Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus
GB2130087A (en) * 1982-09-22 1984-05-31 Dr Joachime Helbig Pharmaceutical oral dosage forms of an active agent capable of forming or releasing bicarbonate ions
US4863741A (en) * 1985-03-25 1989-09-05 Abbott Laboratories Tablet composition for drug combinations
US4874614A (en) * 1985-03-25 1989-10-17 Abbott Laboratories Pharmaceutical tableting method
US4663349A (en) * 1985-12-30 1987-05-05 Merck & Co., Inc. Rectally absorbable form of L-dopa
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
EP0252290B1 (en) * 1986-06-10 1992-06-03 CHIESI FARMACEUTICI S.p.A. Pharmaceutical compositions containing levodopa methyl ester, preparation and therapeutic applications thereof
US4983400A (en) * 1986-06-16 1991-01-08 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
GB8724763D0 (en) * 1987-10-22 1987-11-25 Aps Research Ltd Sustained-release formulations
US4942039A (en) * 1989-05-09 1990-07-17 Miles Inc. Effervescent analgesic antacid composition having reduced sodium content
GB9010039D0 (en) * 1990-05-03 1990-06-27 Reckitt & Colmann Prod Ltd Medicament preparation
US5607969A (en) * 1992-12-24 1997-03-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-DOPA ethyl ester to treat Parkinson's disease
US5354885A (en) * 1992-12-24 1994-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparing ethyl ester of L-DOPA
SI9700186B (sl) 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
US20040151768A1 (en) * 1997-07-23 2004-08-05 Chiesi Farmaceutici S.P.A. Pharmaceutical compositions containing an effervescent acid-base couple
US7060734B1 (en) 1997-09-09 2006-06-13 Alza Corporation Pharmaceutical coating composition and method of use
PT1014951E (pt) * 1997-09-09 2005-03-31 Alza Corp Composicao de revestimento farmaceutica e metodo para a sua utilizacao
JP4372347B2 (ja) * 1998-03-11 2009-11-25 あすか製薬株式会社 発泡性腸溶製剤
US6576250B1 (en) 1998-03-27 2003-06-10 Cima Labs Inc. Pharmaceutical compositions for rectal and vaginal administration
US6974590B2 (en) 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
EP2127642A3 (en) * 1998-08-13 2010-02-24 Cima Labs, Inc. Microemulsions as solid dosage forms for oral administration
EP1135118A1 (en) 1998-11-10 2001-09-26 Teva Pharmaceutical Industries Ltd. Dispersible compositions containing l-dopa ethyl ester
CN1325379A (zh) 1998-11-10 2001-12-05 特瓦制药工业有限公司 L－dopa乙酯的制备方法
KR100299562B1 (ko) 1998-12-29 2001-11-22 우재영 안정성을극대화시킨5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸유도체함유미세과립
AU2005202472B2 (en) * 1999-04-29 2008-12-18 Cima Labs Inc. Effervescent drug delivery system for oral administration
GB0217056D0 (en) * 2002-07-23 2002-08-28 Ass Octel Use
CA2549642C (en) * 2003-12-31 2012-10-30 Cima Labs Inc. Effervescent oral opiate dosage forms and methods of administering opiates
WO2005065317A2 (en) * 2003-12-31 2005-07-21 Cima Labs Inc. Effervescent oral fentanyl dosage form
ATE498395T1 (de) * 2003-12-31 2011-03-15 Cima Labs Inc Allgemein lineare brauseform von fentanyl zur oralen anwendung und verfahren zur verabreichung
JP2016029034A (ja) * 2014-07-18 2016-03-03 ナノメガ メディカル コーポレイションＮａｎｏｍｅｇａ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ 医薬組成物
JP2017203031A (ja) * 2017-07-12 2017-11-16 スティッチング グロニンゲン セントル フォー ドラッグ リサーチ ｐＨ制御パルス送達システム、その調製法及び使用法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3131123A (en) * 1959-03-13 1964-04-28 Lab Francais De Therapeutique Enteric tablets and manufacture thereof
FR2116256A1 (en) 1970-12-02 1972-07-13 Sobio Lab Enteric - coated l-dopa - for treatment of parkinsonism with reduced gastrointestinal side-effects
US3891696A (en) * 1973-11-02 1975-06-24 Interx Research Corp Novel, transient pro-drug forms of l-dopa

Also Published As

Publication number Publication date
US3961041A (en) 1976-06-01
NL7513370A (nl) 1976-05-18
GB1485676A (en) 1977-09-14
SE7512740L (sv) 1976-05-17
JPS5157813A (en) 1976-05-20
FR2290912B1 (es) 1978-07-28
JPS5436645B2 (es) 1979-11-10
CA1047928A (en) 1979-02-06
DE2551280A1 (de) 1976-05-20
FR2290912A1 (fr) 1976-06-11
IT1069069B (it) 1985-03-25

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