ES440110A1 - Procedimiento para la obtencion de compuestos esteroides cardiotonicos. - Google Patents
Procedimiento para la obtencion de compuestos esteroides cardiotonicos.Info
- Publication number
- ES440110A1 ES440110A1 ES440110A ES440110A ES440110A1 ES 440110 A1 ES440110 A1 ES 440110A1 ES 440110 A ES440110 A ES 440110A ES 440110 A ES440110 A ES 440110A ES 440110 A1 ES440110 A1 ES 440110A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- see formula
- groups
- hydrogen
- esterified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000003177 cardiotonic effect Effects 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 3
- -1 formic Chemical class 0.000 abstract 3
- 229930182470 glycoside Natural products 0.000 abstract 3
- 150000002338 glycosides Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 abstract 1
- 229930183217 Genin Natural products 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- JGEMYUOFGVHXKV-OWOJBTEDSA-N fumaraldehyde Chemical class O=C\C=C\C=O JGEMYUOFGVHXKV-OWOJBTEDSA-N 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1085574A CH621803A5 (OSRAM) | 1974-08-08 | 1974-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES440110A1 true ES440110A1 (es) | 1977-02-16 |
Family
ID=4367535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440110A Expired ES440110A1 (es) | 1974-08-08 | 1975-08-08 | Procedimiento para la obtencion de compuestos esteroides cardiotonicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4000125A (OSRAM) |
| JP (1) | JPS5141372A (OSRAM) |
| AR (1) | AR217617A1 (OSRAM) |
| BE (1) | BE832271A (OSRAM) |
| CA (1) | CA1049499A (OSRAM) |
| CH (1) | CH621803A5 (OSRAM) |
| DE (1) | DE2534981A1 (OSRAM) |
| DK (1) | DK139101B (OSRAM) |
| ES (1) | ES440110A1 (OSRAM) |
| FR (1) | FR2281124A1 (OSRAM) |
| GB (1) | GB1484655A (OSRAM) |
| SE (1) | SE418401B (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1144136B (it) * | 1980-03-05 | 1986-10-29 | Zenyaku Kogyo Kk | Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione |
| US5373095A (en) * | 1985-10-18 | 1994-12-13 | The Upjohn Company | Steroid compounds |
| IT1262931B (it) * | 1992-01-16 | 1996-07-22 | Zambon Spa | Composti steroidei 17(piridazin-n-ossido)-sostituiti attivi sul sistema cardiovascolare |
| DE4227616C2 (de) * | 1992-08-20 | 1995-04-13 | Sigma Tau Ind Farmaceuti | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
| PL1853619T3 (pl) * | 2005-03-02 | 2011-03-31 | Univ Maryland | 3-beta-Hydroksy-17-(1H-benzimidazol-1-ilo)-androsta-5,16-dien do zastosowania do leczenia choroby prostaty |
| GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
| US20100048912A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009120565A2 (en) | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| US8785423B2 (en) * | 2008-04-14 | 2014-07-22 | University Of Maryland, Baltimore | Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases |
| EP2393827B1 (en) | 2009-02-05 | 2015-10-07 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| GB2479693B (en) | 2009-02-05 | 2014-04-09 | Tokai Pharmaceuticals Inc | Steroidal CYP17 inhibitors and their use in the treatment of cancer and prostate hyperplasia |
| EP2461814A4 (en) | 2009-08-07 | 2012-12-05 | Tokai Pharmaceuticals Inc | PROSTATE CANCER TREATMENT |
| RU2015137617A (ru) | 2013-03-14 | 2017-04-18 | Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер | Агенты, подавляющие андрогенные рецепторы, и их применение |
| KR20160058774A (ko) | 2013-08-12 | 2016-05-25 | 토카이 파마슈티컬, 아이엔씨. | 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커 |
| WO2017001204A1 (en) * | 2015-06-29 | 2017-01-05 | Universiteit Gent | Methods for the site-selective coupling of a first agent to a second agent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3838163A (en) * | 1968-11-22 | 1974-09-24 | Hoffmann La Roche | Substituted isoxazole derivatives as steroid intermediates |
-
1974
- 1974-08-08 CH CH1085574A patent/CH621803A5/it not_active IP Right Cessation
-
1975
- 1975-07-29 GB GB31789/75A patent/GB1484655A/en not_active Expired
- 1975-07-30 US US05/600,485 patent/US4000125A/en not_active Expired - Lifetime
- 1975-08-05 DE DE19752534981 patent/DE2534981A1/de not_active Ceased
- 1975-08-07 FR FR7524701A patent/FR2281124A1/fr active Granted
- 1975-08-07 AR AR259928A patent/AR217617A1/es active
- 1975-08-07 DK DK358875AA patent/DK139101B/da unknown
- 1975-08-07 SE SE7508908A patent/SE418401B/xx unknown
- 1975-08-07 JP JP50095475A patent/JPS5141372A/ja active Pending
- 1975-08-07 CA CA233,045A patent/CA1049499A/en not_active Expired
- 1975-08-08 BE BE159066A patent/BE832271A/xx unknown
- 1975-08-08 ES ES440110A patent/ES440110A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH621803A5 (OSRAM) | 1981-02-27 |
| AR217617A1 (es) | 1980-04-15 |
| SE7508908L (sv) | 1976-02-09 |
| DE2534981A1 (de) | 1976-02-19 |
| FR2281124B1 (OSRAM) | 1980-05-16 |
| DK139101C (OSRAM) | 1979-05-21 |
| DK139101B (da) | 1978-12-18 |
| FR2281124A1 (fr) | 1976-03-05 |
| CA1049499A (en) | 1979-02-27 |
| SE418401B (sv) | 1981-05-25 |
| BE832271A (fr) | 1975-12-01 |
| JPS5141372A (OSRAM) | 1976-04-07 |
| DK358875A (OSRAM) | 1976-02-09 |
| GB1484655A (en) | 1977-09-01 |
| US4000125A (en) | 1976-12-28 |
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