ES439488A1 - Procedure for the obtaining of new pregnan-21-aldehydes and their derivatives. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the obtaining of new pregnan-21-aldehydes and their derivatives. (Machine-translation by Google Translate, not legally binding)
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Novartis AG
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Ciba Geigy AG
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Priority claimed from CH313472Aexternal-prioritypatent/CH592113A5/xx
Application filed by Ciba Geigy AGfiledCriticalCiba Geigy AG
Publication of ES439488A1publicationCriticalpatent/ES439488A1/en
Procedure for obtaining new pregnan-21-aldehydes and their derivatives of formula ** (See formula) ** wherein R1 and R2 together signify an oxo group or, in each case, a free, esterified or esterified hydroxy group, R3 signifies a free or esterified hydroxy group, R4 signifies an oxo group or a hydroxy group in β together with a hydrogen atom and one of the radicals R5 and R6 means one fluorine atom and the other hydrogen or a fluorine atom, characterized in that a compound of formula ** (See formula) ** wherein R1, R2, R3, R4, R5 and R6 have the meaning indicated above, optionally under transient protection of the 11-hydroxy and/or 20-oxo group, chlorine is added to the double bond 1.2 and the compound 1,2-dichloro obtained dissociates hydrochloric acid and, if desired, the obtained compounds of formula (X), where R1 and R2 together form a gold group or at least one of the radicals R1 and R2 signifies a free hydroxy group, is treated with esterifying or etheating agents, or the compounds obtained of formula (I), wherein at least one of the residues R1 and R2 means an esterified or esterified hydroxy group, it is treated with hydrolyzing means, or in the obtained compounds, where R4 signifies a free hydroxy group, this is oxidized to the oxo group. (Machine-translation by Google Translate, not legally binding)
ES439488A1972-03-031975-07-16Procedure for the obtaining of new pregnan-21-aldehydes and their derivatives. (Machine-translation by Google Translate, not legally binding)
ExpiredES439488A1
(en)