ES412196A1 - Pregnane-21-aldehydes and their derivatives and a process for the production thereof - Google Patents
Pregnane-21-aldehydes and their derivatives and a process for the production thereofInfo
- Publication number
- ES412196A1 ES412196A1 ES412196A ES412196A ES412196A1 ES 412196 A1 ES412196 A1 ES 412196A1 ES 412196 A ES412196 A ES 412196A ES 412196 A ES412196 A ES 412196A ES 412196 A1 ES412196 A1 ES 412196A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- free
- hydroxy group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining new pregnan-21-aldehydes and their derivatives of formula **(See formula)** where R1 and R2 together signify an oxo group or, in each case, a free, esterified or etherized hydroxy group, R3 signifies a free or esterized hydroxy group, R4 signifies an oxo group or a hydroxy group in position together with an atom of hydrogen and one of the residues R5 and R6 signifies a fluorine atom and the other hydrogen or a fluorine atom, characterized in that in a compound of formula **(See formula)** where R3, R5 and R6 have the meaning indicated above and R7 means an oxo group or a free or esterified hydroxyl group, in position, the CH2OH residue is transformed into the group (see formula) and the obtained 11β-acylates are hydrolyzed to the 11-hydroxy compounds, and if desired, the compounds obtained of formula (I), where R1 and R2 together form an oxo group or at least one of the R1 residues and R2 means a free hydroxy group, it is treated with esterifying or etherifying agents, or the compounds obtained of formula (I), where at least one of the residues R1 and R2 means an esterized or etherized hydroxy group, it is treated with hydrolyzing means, or in the obtained compounds, where R4 means a free hydroxy group, this is oxidized to the oxo group. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH313472A CH592113A5 (en) | 1972-03-03 | 1972-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES412196A1 true ES412196A1 (en) | 1976-05-16 |
Family
ID=4249348
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES412196A Expired ES412196A1 (en) | 1972-03-03 | 1973-03-01 | Pregnane-21-aldehydes and their derivatives and a process for the production thereof |
| ES439489A Expired ES439489A1 (en) | 1972-03-03 | 1975-07-16 | Pregnane-21-aldehydes and their derivatives and a process for the production thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439489A Expired ES439489A1 (en) | 1972-03-03 | 1975-07-16 | Pregnane-21-aldehydes and their derivatives and a process for the production thereof |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS4899156A (en) |
| AR (2) | AR205525A1 (en) |
| AT (1) | AT335081B (en) |
| AU (1) | AU470390B2 (en) |
| BE (1) | BE796181A (en) |
| CA (1) | CA994754A (en) |
| CH (1) | CH592113A5 (en) |
| DD (1) | DD102692A5 (en) |
| DE (1) | DE2309030A1 (en) |
| DK (1) | DK132440C (en) |
| ES (2) | ES412196A1 (en) |
| FI (1) | FI52097C (en) |
| FR (1) | FR2181783B1 (en) |
| GB (1) | GB1384994A (en) |
| IE (1) | IE37311B1 (en) |
| IL (1) | IL41579A (en) |
| NL (1) | NL7302832A (en) |
| SE (1) | SE398505B (en) |
| ZA (1) | ZA731218B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5446177A (en) * | 1984-12-28 | 1995-08-29 | Alcon Laboratories, Inc. | Anti-inflammatory compounds for ophthalmic use |
| US5420120A (en) * | 1993-12-17 | 1995-05-30 | Alcon Laboratories, Inc. | Anti-inflammatory glucocorticoid compounds for topical ophthalmic use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2010551A1 (en) * | 1968-06-10 | 1970-02-20 | Ciba Geigy Ag | |
| DE1961867A1 (en) * | 1968-12-12 | 1970-07-02 | Ciba Geigy | Process for the preparation of aldehydes of the pregnane series and their derivatives |
-
1972
- 1972-03-03 CH CH313472A patent/CH592113A5/xx not_active IP Right Cessation
-
1973
- 1973-01-01 AR AR250325A patent/AR205525A1/en active
- 1973-02-12 FI FI730397A patent/FI52097C/en active
- 1973-02-15 SE SE7302147A patent/SE398505B/en unknown
- 1973-02-19 IL IL41579A patent/IL41579A/en unknown
- 1973-02-21 IE IE273/73A patent/IE37311B1/en unknown
- 1973-02-21 ZA ZA731218A patent/ZA731218B/en unknown
- 1973-02-23 CA CA164,420A patent/CA994754A/en not_active Expired
- 1973-02-23 DE DE19732309030 patent/DE2309030A1/en active Pending
- 1973-02-28 NL NL7302832A patent/NL7302832A/xx not_active Application Discontinuation
- 1973-03-01 DD DD169150A patent/DD102692A5/xx unknown
- 1973-03-01 ES ES412196A patent/ES412196A1/en not_active Expired
- 1973-03-01 AU AU52746/73A patent/AU470390B2/en not_active Expired
- 1973-03-02 AT AT188773A patent/AT335081B/en not_active IP Right Cessation
- 1973-03-02 DK DK115873A patent/DK132440C/en active
- 1973-03-02 FR FR7307477A patent/FR2181783B1/fr not_active Expired
- 1973-03-02 GB GB1029073A patent/GB1384994A/en not_active Expired
- 1973-03-02 BE BE128286A patent/BE796181A/en unknown
- 1973-03-03 JP JP48024818A patent/JPS4899156A/ja active Pending
- 1973-03-07 AR AR246927A patent/AR197125A1/en active
-
1975
- 1975-07-16 ES ES439489A patent/ES439489A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL41579A (en) | 1976-09-30 |
| CH592113A5 (en) | 1977-10-14 |
| AU5274673A (en) | 1974-09-05 |
| FI52097C (en) | 1977-06-10 |
| FR2181783A1 (en) | 1973-12-07 |
| AR205525A1 (en) | 1976-05-14 |
| DE2309030A1 (en) | 1973-09-13 |
| SE398505B (en) | 1977-12-27 |
| ZA731218B (en) | 1973-11-28 |
| AT335081B (en) | 1977-02-25 |
| DK132440C (en) | 1976-05-10 |
| BE796181A (en) | 1973-09-03 |
| DD102692A5 (en) | 1973-12-20 |
| IE37311B1 (en) | 1977-06-22 |
| DK132440B (en) | 1975-12-08 |
| GB1384994A (en) | 1975-02-26 |
| CA994754A (en) | 1976-08-10 |
| FR2181783B1 (en) | 1975-10-31 |
| JPS4899156A (en) | 1973-12-15 |
| FI52097B (en) | 1977-02-28 |
| NL7302832A (en) | 1973-09-06 |
| AU470390B2 (en) | 1976-03-11 |
| IE37311L (en) | 1973-09-03 |
| ES439489A1 (en) | 1977-02-16 |
| AR197125A1 (en) | 1974-03-15 |
| ATA188773A (en) | 1976-06-15 |
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