ES438600A1 - Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES438600A1 ES438600A1 ES438600A ES438600A ES438600A1 ES 438600 A1 ES438600 A1 ES 438600A1 ES 438600 A ES438600 A ES 438600A ES 438600 A ES438600 A ES 438600A ES 438600 A1 ES438600 A1 ES 438600A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- groups
- general formula
- translation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 abstract 1
- 239000004312 hexamethylene tetramine Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B29/00—Monoazo dyes prepared by diazotising and coupling
- C09B29/32—Monoazo dyes prepared by diazotising and coupling from coupling components containing a reactive methylene group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDURE FOR OBTAINING NEW DIZZEPINE CANDIDATES OF GENERAL FORMULAS I ** (See formula) ** wherein R 1 signifies hydrogen or an alkyl group with 1 to 3 carbon atoms and R 2 and R 3 signify hydrogen, alkyl groups with 1 to 6 carbon atoms or hydroxyalkyl groups with 2 to 6 carbon atoms, dialkylaminoalkyl groups with a total of 4 to 7 carbon atoms, or aralkyl groups with 7 to 9 carbon atoms, the lower alkyl groups being able to R2 and R3 in the β or γ they are directly or directly linked through an oxygen atom, the imino group, an alkyloimino or hydroxyalkyl-amino group with a maximum of 4 carbon atoms to a bivalent radical with a total of 10 carbon atoms and the A and B can be substituted by halogen up to the atomic number 35, alkyl or alkoxy groups, each having 1 to 6 carbon atoms, trifluoromethyl groups or nitro groups, as well as the 5-oxides and the addition salts of the compounds of the general formula I with inorganic and organic acids, characterized in that a reactive ester of a compound of general formula II ** (See formula) ** where R1, R2 and R3 have the meanings indicated under formula I and rings A and B may be substituted as indicated therein, reacted with ammonia or hexamethylenetetramine and the reaction product of general formula I obtained, if desired, oxidizes its 5-oxide or, if desired, is transformed into an addition salt with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH173872A CH567020A5 (en) | 1972-02-07 | 1972-02-07 | 4h-s-triazolo (1,5-a) (1,4) benzodiazepine-2-carboxylic acid amide(s) - CNS inhibitors, anticonvulsants, tranquillizers, etc. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES438600A1 true ES438600A1 (en) | 1977-03-01 |
Family
ID=4217420
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES411321A Expired ES411321A1 (en) | 1972-02-07 | 1973-02-05 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES438601A Expired ES438601A1 (en) | 1972-02-07 | 1975-06-16 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES438600A Expired ES438600A1 (en) | 1972-02-07 | 1975-06-16 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES438602A Expired ES438602A1 (en) | 1972-02-07 | 1975-06-16 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES411321A Expired ES411321A1 (en) | 1972-02-07 | 1973-02-05 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES438601A Expired ES438601A1 (en) | 1972-02-07 | 1975-06-16 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES438602A Expired ES438602A1 (en) | 1972-02-07 | 1975-06-16 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT328454B (en) |
| AU (1) | AU476040B2 (en) |
| CH (1) | CH567020A5 (en) |
| CS (3) | CS186798B2 (en) |
| ES (4) | ES411321A1 (en) |
| HU (1) | HU166827B (en) |
| PL (3) | PL89204B1 (en) |
| SU (3) | SU520918A3 (en) |
| ZA (1) | ZA73531B (en) |
-
1972
- 1972-02-07 CH CH173872A patent/CH567020A5/en not_active IP Right Cessation
-
1973
- 1973-01-24 ZA ZA730531A patent/ZA73531B/en unknown
- 1973-01-31 SU SU1878321A patent/SU520918A3/en active
- 1973-02-05 ES ES411321A patent/ES411321A1/en not_active Expired
- 1973-02-05 AU AU51780/73A patent/AU476040B2/en not_active Expired
- 1973-02-06 PL PL1973160619A patent/PL89204B1/en unknown
- 1973-02-06 PL PL1973178148A patent/PL92656B1/en unknown
- 1973-02-06 AT AT103873A patent/AT328454B/en not_active IP Right Cessation
- 1973-02-06 PL PL1973178147A patent/PL94159B1/en unknown
- 1973-02-06 HU HUCI1336A patent/HU166827B/hu unknown
- 1973-02-07 CS CS7600006548A patent/CS186798B2/en unknown
- 1973-02-07 CS CS7300000905A patent/CS186770B2/en unknown
- 1973-02-07 CS CS7600006547A patent/CS186797B2/en unknown
-
1974
- 1974-10-09 SU SU2068917A patent/SU555851A3/en active
- 1974-10-09 SU SU2067388A patent/SU552028A3/en active
-
1975
- 1975-06-16 ES ES438601A patent/ES438601A1/en not_active Expired
- 1975-06-16 ES ES438600A patent/ES438600A1/en not_active Expired
- 1975-06-16 ES ES438602A patent/ES438602A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES438602A1 (en) | 1977-03-16 |
| ES438601A1 (en) | 1977-04-01 |
| PL89204B1 (en) | 1976-11-30 |
| ATA103873A (en) | 1975-06-15 |
| PL94159B1 (en) | 1977-07-30 |
| AT328454B (en) | 1976-03-25 |
| CS186798B2 (en) | 1978-12-29 |
| CH567020A5 (en) | 1975-09-30 |
| ES411321A1 (en) | 1976-04-01 |
| SU520918A3 (en) | 1976-07-05 |
| HU166827B (en) | 1975-06-28 |
| ZA73531B (en) | 1973-10-31 |
| AU5178073A (en) | 1974-08-08 |
| CS186770B2 (en) | 1978-12-29 |
| SU552028A3 (en) | 1977-03-25 |
| PL92656B1 (en) | 1977-04-30 |
| CS186797B2 (en) | 1978-12-29 |
| AU476040B2 (en) | 1976-09-09 |
| SU555851A3 (en) | 1977-04-25 |
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