ES437269A1 - Cephalosporing antibiotics - Google Patents
Cephalosporing antibioticsInfo
- Publication number
- ES437269A1 ES437269A1 ES437269A ES437269A ES437269A1 ES 437269 A1 ES437269 A1 ES 437269A1 ES 437269 A ES437269 A ES 437269A ES 437269 A ES437269 A ES 437269A ES 437269 A1 ES437269 A1 ES 437269A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- syn isomer
- ceph
- phenyl
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
Preparation of the syn isomer or of a mixture of syn isomer and anti isomer, where the content of the syn isomer is at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids with antibiotic activity and the formula I < IMAGE > in which B is > S or > S->O R<1> is furyl, thienyl or phenyl and R<2> is C1-C4-alkyl, C3-C7-cycloalkyl or phenyl, and of their non-toxic salts, including their solvates, and esters by acylation of the corresponding 7-amino compound, where appropriate with intermediate protection of the 4-carboxyl group and/or of the 3-carbamoyloxymethyl group, and subsequent isomerisation of a ceph-2-em compound which is obtained where appropriate to the ceph-3-em compound. The compounds are distinguished by a broad spectrum of action on pathogenic microorganisms, the ability to resist beta -lactamases and good stability in vivo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3964573A GB1453049A (en) | 1973-08-21 | 1973-08-21 | Cephalosporing antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES437269A1 true ES437269A1 (en) | 1977-01-01 |
Family
ID=10410683
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES429388A Expired ES429388A1 (en) | 1973-08-21 | 1974-08-20 | Cephalosporing antibiotics |
| ES437269A Expired ES437269A1 (en) | 1973-08-21 | 1975-04-30 | Cephalosporing antibiotics |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES429388A Expired ES429388A1 (en) | 1973-08-21 | 1974-08-20 | Cephalosporing antibiotics |
Country Status (32)
| Country | Link |
|---|---|
| JP (2) | JPS562077B2 (en) |
| AR (2) | AR212076A1 (en) |
| AT (1) | AT340042B (en) |
| AU (1) | AU473550B2 (en) |
| BE (1) | BE819004R (en) |
| BG (2) | BG23903A3 (en) |
| CA (1) | CA1057283A (en) |
| CH (2) | CH613975A5 (en) |
| CS (2) | CS204988B2 (en) |
| CY (1) | CY945A (en) |
| DD (1) | DD114417A5 (en) |
| DE (2) | DE2462376A1 (en) |
| DK (1) | DK147683C (en) |
| ES (2) | ES429388A1 (en) |
| FI (1) | FI65623C (en) |
| FR (1) | FR2241318B2 (en) |
| GB (1) | GB1453049A (en) |
| GT (1) | GT198302370A (en) |
| HK (1) | HK17378A (en) |
| HU (1) | HU170000B (en) |
| IE (1) | IE39764B1 (en) |
| IL (1) | IL45505A (en) |
| KE (1) | KE2816A (en) |
| LU (2) | LU70765A1 (en) |
| MY (1) | MY7800188A (en) |
| NL (1) | NL154741B (en) |
| NO (1) | NO152751C (en) |
| PL (2) | PL98962B1 (en) |
| RO (2) | RO64129A (en) |
| SU (1) | SU633483A3 (en) |
| YU (2) | YU36737B (en) |
| ZA (1) | ZA745331B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
| CA1093549A (en) * | 1976-02-16 | 1981-01-13 | Michael Gregson | Cephalosporin antibiotics |
| FR2345153A1 (en) * | 1976-03-25 | 1977-10-21 | Roussel Uclaf | NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
| FI771866A (en) * | 1976-06-28 | 1977-12-29 | Fujisawa Pharmaceutical Co | |
| GB1598568A (en) * | 1977-04-19 | 1981-09-23 | Glaxo Lab Ltd | Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid |
| IT1162442B (en) * | 1978-01-17 | 1987-04-01 | Glaxo Group Ltd | PROCEDURE FOR PREPARING THE CRYSTALLINE SHAPED SODIUM SALT OF CEFUROSSIMA |
| DE2804040C3 (en) * | 1978-01-31 | 1981-03-19 | Hoechst Ag, 6000 Frankfurt | Process for the preparation of cephem compounds |
| US4341777A (en) * | 1979-09-10 | 1982-07-27 | Glaxo Group Limited | Cephalosporin antibiotic |
| IT1190734B (en) * | 1982-03-11 | 1988-02-24 | Opos Biochimica Srl | PROCEDURE FOR THE PREPARATION OF CEFUROXIMA AND INTERMEDIATES USED IN SUCH PROCEDURE |
| GB8320520D0 (en) * | 1983-07-29 | 1983-09-01 | Glaxo Group Ltd | Chemical process |
| GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
| GB8810394D0 (en) * | 1988-05-03 | 1988-06-08 | Glaxo Group Ltd | Chemical process |
| WO2000053609A1 (en) * | 1999-03-09 | 2000-09-14 | Ranbaxy Laboratories Limited | Process for the preparation of cefuroxime |
| JP2006510357A (en) * | 2002-11-22 | 2006-03-30 | ザ ジョーンズ ホプキンズ ユニバーシティ | Targets for the treatment of cognitive impairment |
| WO2004050663A2 (en) * | 2002-12-05 | 2004-06-17 | Orchid Chemicals & Pharmaceuticals Ltd | An improved process for the preparation of cefuroxime sodium |
| JP2008275173A (en) * | 2008-08-04 | 2008-11-13 | Toshiba Corp | Branch pipe |
| WO2013024373A1 (en) | 2011-08-12 | 2013-02-21 | Dhanuka Laboratories Ltd. | Pharmaceutical composition comprising cefuroxime |
| WO2013038323A1 (en) | 2011-09-13 | 2013-03-21 | Unimark Remedies Ltd. | Taste masked pharmaceutical compositions of cefuroxime axetil |
| KR101497420B1 (en) | 2013-07-05 | 2015-03-03 | 삼성중공업 주식회사 | LNG transportation Apparatus for reducing Boil-Off Gas |
| CN105884799A (en) * | 2015-09-23 | 2016-08-24 | 石药集团中诺药业（石家庄）有限公司 | Novel cefuroxime sodium compound |
-
1973
- 1973-08-21 GB GB3964573A patent/GB1453049A/en not_active Expired
-
1974
- 1974-08-13 CY CY945A patent/CY945A/en unknown
- 1974-08-19 RO RO7479828A patent/RO64129A/en unknown
- 1974-08-19 RO RO7486148A patent/RO69607A/en unknown
- 1974-08-20 CA CA207,441A patent/CA1057283A/en not_active Expired
- 1974-08-20 DD DD180622A patent/DD114417A5/xx unknown
- 1974-08-20 IE IE1735/74A patent/IE39764B1/en unknown
- 1974-08-20 CS CS745783A patent/CS204988B2/en unknown
- 1974-08-20 IL IL45505A patent/IL45505A/en unknown
- 1974-08-20 FI FI2456/74A patent/FI65623C/en active
- 1974-08-20 AT AT676374A patent/AT340042B/en not_active IP Right Cessation
- 1974-08-20 NO NO742986A patent/NO152751C/en unknown
- 1974-08-20 YU YU2283/74A patent/YU36737B/en unknown
- 1974-08-20 ZA ZA00745331A patent/ZA745331B/en unknown
- 1974-08-20 PL PL1974173581A patent/PL98962B1/en unknown
- 1974-08-20 AU AU72531/74A patent/AU473550B2/en not_active Expired
- 1974-08-20 DE DE19742462376 patent/DE2462376A1/en active Pending
- 1974-08-20 CS CS745783A patent/CS204989B2/en unknown
- 1974-08-20 CH CH1135374A patent/CH613975A5/en not_active IP Right Cessation
- 1974-08-20 LU LU70765A patent/LU70765A1/xx active Protection Beyond IP Right Term
- 1974-08-20 DK DK443274A patent/DK147683C/en active
- 1974-08-20 BG BG7500031288A patent/BG23903A3/en unknown
- 1974-08-20 JP JP9545674A patent/JPS562077B2/ja not_active Expired
- 1974-08-20 BE BE147745A patent/BE819004R/en active
- 1974-08-20 ES ES429388A patent/ES429388A1/en not_active Expired
- 1974-08-20 BG BG7400027524A patent/BG25801A3/en unknown
- 1974-08-20 NL NL747411095A patent/NL154741B/en not_active IP Right Cessation
- 1974-08-20 PL PL1974196434A patent/PL115805B1/en unknown
- 1974-08-20 AR AR255247A patent/AR212076A1/en active
- 1974-08-20 LU LU88269C patent/LU88269I2/xx unknown
- 1974-08-20 DE DE2439880A patent/DE2439880C3/en not_active Expired
- 1974-08-21 HU HUGA1166A patent/HU170000B/hu unknown
- 1974-08-21 FR FR7428750A patent/FR2241318B2/fr not_active Expired
-
1975
- 1975-04-30 ES ES437269A patent/ES437269A1/en not_active Expired
- 1975-05-13 AR AR258764A patent/AR212156A1/en active
-
1976
- 1976-04-08 SU SU762343055A patent/SU633483A3/en active
-
1978
- 1978-02-06 KE KE2816A patent/KE2816A/en unknown
- 1978-03-30 HK HK173/78A patent/HK17378A/en unknown
- 1978-09-28 CH CH1013378A patent/CH615931A5/en not_active IP Right Cessation
- 1978-12-31 MY MY1978188A patent/MY7800188A/en unknown
-
1980
- 1980-05-28 JP JP7210780A patent/JPS5649388A/en active Pending
-
1981
- 1981-02-05 YU YU307/81A patent/YU41231B/en unknown
-
1983
- 1983-05-30 GT GT198302370A patent/GT198302370A/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981007 |