ES435189A1 - 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners - Google Patents

17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners

Info

Publication number
ES435189A1
ES435189A1 ES435189A ES435189A ES435189A1 ES 435189 A1 ES435189 A1 ES 435189A1 ES 435189 A ES435189 A ES 435189A ES 435189 A ES435189 A ES 435189A ES 435189 A1 ES435189 A1 ES 435189A1
Authority
ES
Spain
Prior art keywords
formula
hydroxy
lactones
ene
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435189A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES435189A1 publication Critical patent/ES435189A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Abstract

Procedure for obtaining γ -lactones of 17-hydroxy-7- (lower alkyl) carbonyl-3-oxo-17αpregn-4-ene-21-carboxylic acids, of general formula: **(See formula)** and the corresponding compounds, in which lactone is in the form of the corresponding 17-hydroxy-21-carboxylic acids and the alkali metal, alkaline earth metal/2 and ammonium salts of 17-hydroxy-21-carboxylic acids; wherein Z is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal/2, ammonium, and alkyl; the dotted line indicates that bond Δ 1 is selected from the group consisting of saturated and unsaturated bonds; the wavy line indicates that the configuration at position-7 is selected from the α and β configurations and when Z is alkyl and the 1,2-bond is saturated, X in formula (Ia) is selected from the group consisting of oxygen and sulfur, otherwise X is oxygen; characterized in that a compound of the formula is contacted: **(See formula)** where the dotted and wavy lines are as defined above, with a compound of the formula: Z-XH wherein Z and X are as defined above, in order to provide the corresponding compound of formula (Ia) wherein Z is alkyl. (Machine-translation by Google Translate, not legally binding)
ES435189A 1971-08-25 1975-02-28 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners Expired ES435189A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17492271A 1971-08-25 1971-08-25

Publications (1)

Publication Number Publication Date
ES435189A1 true ES435189A1 (en) 1976-12-01

Family

ID=22638078

Family Applications (2)

Application Number Title Priority Date Filing Date
ES406044A Expired ES406044A1 (en) 1971-08-25 1972-08-23 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners
ES435189A Expired ES435189A1 (en) 1971-08-25 1975-02-28 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES406044A Expired ES406044A1 (en) 1971-08-25 1972-08-23 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners

Country Status (21)

Country Link
JP (2) JPS5839840B2 (en)
AT (1) AT323907B (en)
AU (1) AU475957B2 (en)
BE (1) BE787940A (en)
CA (1) CA970361A (en)
CH (2) CH601350A5 (en)
DE (1) DE2241680C2 (en)
DK (1) DK133954B (en)
ES (2) ES406044A1 (en)
FI (1) FI50429C (en)
FR (1) FR2150852B1 (en)
GB (1) GB1368005A (en)
IE (1) IE36653B1 (en)
IL (1) IL40197A (en)
KE (1) KE2813A (en)
MY (1) MY7800121A (en)
NL (1) NL176569C (en)
NO (1) NO134990C (en)
PH (1) PH9271A (en)
SE (2) SE380533B (en)
ZA (1) ZA725839B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069219A (en) * 1976-12-27 1978-01-17 G. D. Searle & Co. 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters
FR2496669A1 (en) * 1980-12-23 1982-06-25 Roussel Uclaf NOVEL STEROID 3-KETO4 OR 1-4 SUBSTITUTED DERIVATIVES IN POSITION 7, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
DE3111951A1 (en) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7 (ALPHA) -ALKOXYCARBONYL-15SS-METHYLENE-4-ANDROSTENE, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICINAL PRODUCT
JPS57169230A (en) * 1981-04-10 1982-10-18 Matsushita Electric Ind Co Ltd Oil-immersed plastic ilm capacitor
US5296318A (en) * 1993-03-05 1994-03-22 Bell Communications Research, Inc. Rechargeable lithium intercalation battery with hybrid polymeric electrolyte
BRPI0515106A (en) * 2004-09-09 2008-07-08 Pharmacia Corp process for preparing substituted 7 (alpha) -alkoxycarbonyl steroids

Also Published As

Publication number Publication date
AU4578772A (en) 1974-02-28
FI50429C (en) 1976-03-10
IL40197A0 (en) 1972-10-29
JPS611080B2 (en) 1986-01-13
BE787940A (en) 1973-02-26
FR2150852B1 (en) 1975-10-17
DE2241680A1 (en) 1973-03-01
NL176569C (en) 1985-05-01
MY7800121A (en) 1978-12-31
SE404024B (en) 1978-09-18
DK133954B (en) 1976-08-16
FR2150852A1 (en) 1973-04-13
ZA725839B (en) 1973-10-31
PH9271A (en) 1975-07-30
DE2241680C2 (en) 1982-09-09
AU475957B2 (en) 1976-09-09
CA970361A (en) 1975-07-01
IE36653L (en) 1973-02-25
CH603689A5 (en) 1978-08-31
JPS5839840B2 (en) 1983-09-01
JPS4832860A (en) 1973-05-02
GB1368005A (en) 1974-09-25
AT323907B (en) 1975-08-11
NL176569B (en) 1984-12-03
IL40197A (en) 1976-05-31
SE7415187L (en) 1974-12-04
JPS5890598A (en) 1983-05-30
FI50429B (en) 1975-12-01
KE2813A (en) 1978-02-10
DK133954C (en) 1977-01-24
NL7211559A (en) 1973-02-27
NO134990B (en) 1976-10-11
SE380533B (en) 1975-11-10
IE36653B1 (en) 1977-01-19
ES406044A1 (en) 1976-01-16
CH601350A5 (en) 1978-07-14
NO134990C (en) 1977-01-26

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