ES434961A1 - Procedimiento para la preparacion de nuevos derivados nico-tinicos del estriol de actividades hipolipidemiante y estro-gena moduladas. - Google Patents
Procedimiento para la preparacion de nuevos derivados nico-tinicos del estriol de actividades hipolipidemiante y estro-gena moduladas.Info
- Publication number
- ES434961A1 ES434961A1 ES434961A ES434961A ES434961A1 ES 434961 A1 ES434961 A1 ES 434961A1 ES 434961 A ES434961 A ES 434961A ES 434961 A ES434961 A ES 434961A ES 434961 A1 ES434961 A1 ES 434961A1
- Authority
- ES
- Spain
- Prior art keywords
- substitution
- estriol
- nicotic
- etherification
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002166 estriols Chemical class 0.000 title 1
- 238000006467 substitution reaction Methods 0.000 abstract 4
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 229960001348 estriol Drugs 0.000 abstract 2
- 238000006266 etherification reaction Methods 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB871274A GB1452794A (en) | 1974-02-26 | 1974-02-26 | Estriol derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES434961A1 true ES434961A1 (es) | 1976-12-16 |
Family
ID=9857798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES434961A Expired ES434961A1 (es) | 1974-02-26 | 1975-02-21 | Procedimiento para la preparacion de nuevos derivados nico-tinicos del estriol de actividades hipolipidemiante y estro-gena moduladas. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5842199B2 (OSRAM) |
| AR (1) | AR206704A1 (OSRAM) |
| BE (1) | BE826016A (OSRAM) |
| BR (1) | BR7501131A (OSRAM) |
| CA (1) | CA1062699A (OSRAM) |
| CH (1) | CH614218A5 (OSRAM) |
| ES (1) | ES434961A1 (OSRAM) |
| FR (1) | FR2261775B1 (OSRAM) |
| GB (1) | GB1452794A (OSRAM) |
| IE (1) | IE40689B1 (OSRAM) |
| IT (1) | IT1048803B (OSRAM) |
| LU (1) | LU71909A1 (OSRAM) |
| NL (1) | NL180108C (OSRAM) |
| SE (1) | SE419091B (OSRAM) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60258198A (ja) * | 1984-06-04 | 1985-12-20 | Amano Pharmaceut Co Ltd | トリテルペンアルコ−ル有機酸エステル及びその製造法 |
-
1974
- 1974-02-26 GB GB871274A patent/GB1452794A/en not_active Expired
-
1975
- 1975-01-01 AR AR257778A patent/AR206704A1/es active
- 1975-02-04 FR FR7503357A patent/FR2261775B1/fr not_active Expired
- 1975-02-11 CH CH171975A patent/CH614218A5/xx not_active IP Right Cessation
- 1975-02-21 ES ES434961A patent/ES434961A1/es not_active Expired
- 1975-02-25 IT IT20627/75A patent/IT1048803B/it active
- 1975-02-25 SE SE7502107A patent/SE419091B/xx not_active IP Right Cessation
- 1975-02-25 LU LU71909A patent/LU71909A1/xx unknown
- 1975-02-25 CA CA220,864A patent/CA1062699A/fr not_active Expired
- 1975-02-25 BR BR1131/75A patent/BR7501131A/pt unknown
- 1975-02-25 IE IE384/75A patent/IE40689B1/xx unknown
- 1975-02-26 JP JP50024452A patent/JPS5842199B2/ja not_active Expired
- 1975-02-26 BE BE153773A patent/BE826016A/xx unknown
- 1975-02-26 NL NLAANVRAGE7502299,A patent/NL180108C/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE826016A (fr) | 1975-06-16 |
| LU71909A1 (OSRAM) | 1975-08-20 |
| JPS5842199B2 (ja) | 1983-09-17 |
| NL180108C (nl) | 1987-01-02 |
| FR2261775A1 (OSRAM) | 1975-09-19 |
| AR206704A1 (es) | 1976-08-13 |
| IT1048803B (it) | 1980-12-20 |
| GB1452794A (en) | 1976-10-13 |
| NL180108B (nl) | 1986-08-01 |
| NL7502299A (nl) | 1975-08-28 |
| BR7501131A (pt) | 1975-12-02 |
| CH614218A5 (en) | 1979-11-15 |
| CA1062699A (fr) | 1979-09-18 |
| JPS50142555A (OSRAM) | 1975-11-17 |
| SE419091B (sv) | 1981-07-13 |
| SE7502107L (OSRAM) | 1975-08-27 |
| FR2261775B1 (OSRAM) | 1980-05-16 |
| IE40689B1 (en) | 1979-08-01 |
| IE40689L (en) | 1975-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971001 |