GB1452794A - Estriol derivatives - Google Patents

Estriol derivatives

Info

Publication number
GB1452794A
GB1452794A GB871274A GB871274A GB1452794A GB 1452794 A GB1452794 A GB 1452794A GB 871274 A GB871274 A GB 871274A GB 871274 A GB871274 A GB 871274A GB 1452794 A GB1452794 A GB 1452794A
Authority
GB
United Kingdom
Prior art keywords
estriol
nicotinoyl
dinicotinate
esterification
feb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB871274A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Theramex SAM
Original Assignee
Laboratoire Theramex SAM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex SAM filed Critical Laboratoire Theramex SAM
Priority to GB871274A priority Critical patent/GB1452794A/en
Priority to AR257778A priority patent/AR206704A1/en
Priority to FR7503357A priority patent/FR2261775B1/fr
Priority to CH171975A priority patent/CH614218A5/en
Priority to ES434961A priority patent/ES434961A1/en
Priority to SE7502107A priority patent/SE419091B/en
Priority to BR1131/75A priority patent/BR7501131A/en
Priority to IE384/75A priority patent/IE40689B1/en
Priority to CA220,864A priority patent/CA1062699A/en
Priority to LU71909A priority patent/LU71909A1/xx
Priority to IT20627/75A priority patent/IT1048803B/en
Priority to BE153773A priority patent/BE826016A/en
Priority to NLAANVRAGE7502299,A priority patent/NL180108C/en
Priority to JP50024452A priority patent/JPS5842199B2/en
Publication of GB1452794A publication Critical patent/GB1452794A/en
Priority to US05/736,931 priority patent/US4110324A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1452794 Estriol nicotinates THERAMEX SA 26 Feb 1975 [26 Feb 1974] 8712/74 Heading C2U The invention comprises compounds of formula (wherein R is nicotinoyl or its N-oxide; and R<SP>1</SP> is C 3-7 aliphatic organic acyl; aromatic, alicyclic or heterocyclic organic acyl; or Me, Et, Pr, allyl, methallyl, cyclopentyl or dialkylaminoalkyl); and their preparation from estriol or its 3-ethers by esterification with nicotinoyl chloride or its N-oxide; or from estriol 16,17- dinicotinate or its N,N<SP>1</SP>-dioxide by esterification with an appropriate acylating agent. The nicotinoyl groups may be N-oxidized by reaction with per-acids. Estriol 16,17-dinicotinate is prepared by selective hydrolysis of the trinicotinate. Compounds I are credited with hypolipidaemic and anti-arteriosclerotic activity, and may be made up with carriers into pharmaceutical compositions for oral, parenteral, rectal and nasal (aerosol) administration.
GB871274A 1974-02-26 1974-02-26 Estriol derivatives Expired GB1452794A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GB871274A GB1452794A (en) 1974-02-26 1974-02-26 Estriol derivatives
AR257778A AR206704A1 (en) 1974-02-26 1975-01-01 PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 16,17-DI-DICOTINOIL-ESTRIOL AND ITS N-OXODES
FR7503357A FR2261775B1 (en) 1974-02-26 1975-02-04
CH171975A CH614218A5 (en) 1974-02-26 1975-02-11 Process for the preparation of estriol derivatives
ES434961A ES434961A1 (en) 1974-02-26 1975-02-21 Estriol derivatives
IE384/75A IE40689B1 (en) 1974-02-26 1975-02-25 Novel estriol derivatives
BR1131/75A BR7501131A (en) 1974-02-26 1975-02-25 NEW STRIOL DERIVED COMPOUNDS PROCESS FOR ITS PREPARATION AND APPLICATION IN HUMAN MEDICINE FOR HYPOLIPIDEMIANT AND ANTI-ATEROESCLEROTIC ESTROGENIC TREATMENTS
SE7502107A SE419091B (en) 1974-02-26 1975-02-25 PROCEDURE FOR THE PREPARATION OF NICOTIC ACID ESTERS AND DERIVATIVES OF OSTRIOL
CA220,864A CA1062699A (en) 1974-02-26 1975-02-25 Nicotinic dervatives of estriol having modified hypolipidimic and estrogenic activity
LU71909A LU71909A1 (en) 1974-02-26 1975-02-25
IT20627/75A IT1048803B (en) 1974-02-26 1975-02-25 NICOTINIC DERIVATIVES OF ESTRIOL HAVING HYPOLIPIDEMIC AND MODULATED EXTROGEN ACTIVITY
BE153773A BE826016A (en) 1974-02-26 1975-02-26 NEW NICOTINIC DERIVATIVES OF ESTRIOL WITH HYPOLIPIDEMITING ACTIVITIES AND MODULATED ESTROGEN
NLAANVRAGE7502299,A NL180108C (en) 1974-02-26 1975-02-26 PROCESS FOR PREPARING A MEDICINAL PRODUCT BASED ON A 3,16-ALFA, 17BETA TRIHYDROXY-1,3,5 (10) OESTRATRY NESTER AND METHOD FOR PREPARING THE SUITABLE COMPOUND.
JP50024452A JPS5842199B2 (en) 1974-02-26 1975-02-26 ESTRIO-RUUUDOUTAINO
US05/736,931 US4110324A (en) 1974-02-26 1976-10-29 Nicotinic derivatives of estriol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB871274A GB1452794A (en) 1974-02-26 1974-02-26 Estriol derivatives

Publications (1)

Publication Number Publication Date
GB1452794A true GB1452794A (en) 1976-10-13

Family

ID=9857798

Family Applications (1)

Application Number Title Priority Date Filing Date
GB871274A Expired GB1452794A (en) 1974-02-26 1974-02-26 Estriol derivatives

Country Status (14)

Country Link
JP (1) JPS5842199B2 (en)
AR (1) AR206704A1 (en)
BE (1) BE826016A (en)
BR (1) BR7501131A (en)
CA (1) CA1062699A (en)
CH (1) CH614218A5 (en)
ES (1) ES434961A1 (en)
FR (1) FR2261775B1 (en)
GB (1) GB1452794A (en)
IE (1) IE40689B1 (en)
IT (1) IT1048803B (en)
LU (1) LU71909A1 (en)
NL (1) NL180108C (en)
SE (1) SE419091B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60258198A (en) * 1984-06-04 1985-12-20 Amano Pharmaceut Co Ltd Triterpene alcohol organic acid ester and its preparation

Also Published As

Publication number Publication date
NL180108B (en) 1986-08-01
IT1048803B (en) 1980-12-20
FR2261775B1 (en) 1980-05-16
AR206704A1 (en) 1976-08-13
IE40689L (en) 1975-08-26
IE40689B1 (en) 1979-08-01
SE7502107L (en) 1975-08-27
FR2261775A1 (en) 1975-09-19
CA1062699A (en) 1979-09-18
NL7502299A (en) 1975-08-28
JPS50142555A (en) 1975-11-17
SE419091B (en) 1981-07-13
ES434961A1 (en) 1976-12-16
LU71909A1 (en) 1975-08-20
BR7501131A (en) 1975-12-02
BE826016A (en) 1975-06-16
CH614218A5 (en) 1979-11-15
JPS5842199B2 (en) 1983-09-17
NL180108C (en) 1987-01-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee