ES434446A1 - Naphthoylamino alkyl phenoxy-alkyl-carboxylic acid derivatives - Google Patents
Naphthoylamino alkyl phenoxy-alkyl-carboxylic acid derivativesInfo
- Publication number
- ES434446A1 ES434446A1 ES434446A ES434446A ES434446A1 ES 434446 A1 ES434446 A1 ES 434446A1 ES 434446 A ES434446 A ES 434446A ES 434446 A ES434446 A ES 434446A ES 434446 A1 ES434446 A1 ES 434446A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- formula
- group
- signifies
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 125000003158 alcohol group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000005209 naphthoic acids Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of derivatives of phenoxyalkoxycarboxylic acids of the general formula I **(See formula)** wherein R1 and R2 signify hydrogen or a lower alcohol group, Z signifies a hydroxyl group or a lower alkoxy group and n signifies numbers 1 or 2, characterized in that compounds of the general formula II are reacted **(See formula)** in which n has the meanings mentioned above, optionally after introduction of customary protecting groups for the amino or hydroxyl group, which in each case must be protected in an intermediate way, with a derivative of naphthoic acid III and with a compound of formula IV **(See formula)** in which R1, R2 and Z have the meanings indicated above and X represents a reactive group, or in the case where R1 and R2 signify lower alcohol groups, with a mixture of an aliphatic ketone, chloroform and an alkali metal hydroxide, optionally, the substituent Z is transformed, after condensation, and the compounds I obtained are transformed, if desired, into pharmacologically harmless salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742405622 DE2405622A1 (en) | 1974-02-06 | 1974-02-06 | NEW PHENOXYALKYLCARBONIC ACID DERIVATIVES AND METHOD FOR MANUFACTURING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES434446A1 true ES434446A1 (en) | 1976-12-16 |
Family
ID=5906747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES434446A Expired ES434446A1 (en) | 1974-02-06 | 1975-02-04 | Naphthoylamino alkyl phenoxy-alkyl-carboxylic acid derivatives |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS50108249A (en) |
| AR (1) | AR203228A1 (en) |
| AT (1) | AT335439B (en) |
| BE (1) | BE825176A (en) |
| CA (1) | CA1043806A (en) |
| DD (1) | DD120015A5 (en) |
| DE (1) | DE2405622A1 (en) |
| DK (1) | DK36575A (en) |
| ES (1) | ES434446A1 (en) |
| FI (1) | FI750292A (en) |
| FR (1) | FR2259597B1 (en) |
| GB (1) | GB1449586A (en) |
| HU (1) | HU169491B (en) |
| IE (1) | IE40585B1 (en) |
| IL (1) | IL46543A0 (en) |
| NL (1) | NL7501220A (en) |
| SE (1) | SE7501083L (en) |
| SU (1) | SU674670A3 (en) |
| ZA (1) | ZA75703B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1812315A1 (en) * | 1967-12-28 | 1969-12-04 | Nippon Electric Co | Electromechanical vibration device |
| US4214094A (en) | 1977-03-30 | 1980-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-phenyl substituted-alkyl ethers and the preparation thereof |
| DE2809377A1 (en) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | PHENOXYALKYL CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| JPS5649906B2 (en) * | 1978-05-12 | 1981-11-25 | Boehringer Mannheim Gmbh | Manufacture of alphaa*44*44chlorobenzoylaminoo ethyl**phenoxy**isoethylacetic acid |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| ATE520651T1 (en) * | 2006-10-23 | 2011-09-15 | Pfizer | SUBSTITUTED PHENYLMETHYLBICYCLOCARBONIC ACID AMIDE COMPOUNDS |
| WO2012003145A2 (en) | 2010-07-02 | 2012-01-05 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
| US9714238B2 (en) | 2010-07-02 | 2017-07-25 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
-
1974
- 1974-02-06 DE DE19742405622 patent/DE2405622A1/en not_active Withdrawn
-
1975
- 1975-01-29 CA CA218,899A patent/CA1043806A/en not_active Expired
- 1975-01-31 SE SE7501083A patent/SE7501083L/xx unknown
- 1975-02-03 DK DK36575*#A patent/DK36575A/da unknown
- 1975-02-03 GB GB448375A patent/GB1449586A/en not_active Expired
- 1975-02-03 NL NL7501220A patent/NL7501220A/en unknown
- 1975-02-03 FI FI750292A patent/FI750292A/fi not_active Application Discontinuation
- 1975-02-03 DD DD183967A patent/DD120015A5/xx unknown
- 1975-02-03 IL IL46543A patent/IL46543A0/en unknown
- 1975-02-04 BE BE153054A patent/BE825176A/en unknown
- 1975-02-04 ES ES434446A patent/ES434446A1/en not_active Expired
- 1975-02-04 ZA ZA00750703A patent/ZA75703B/en unknown
- 1975-02-05 SU SU752104685A patent/SU674670A3/en active
- 1975-02-05 IE IE231/75A patent/IE40585B1/en unknown
- 1975-02-05 HU HUBO1533A patent/HU169491B/hu unknown
- 1975-02-05 FR FR7503585A patent/FR2259597B1/fr not_active Expired
- 1975-02-05 AT AT85775*#A patent/AT335439B/en not_active IP Right Cessation
- 1975-02-06 JP JP50015856A patent/JPS50108249A/ja active Pending
- 1975-02-06 AR AR257551A patent/AR203228A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| AU7701874A (en) | 1976-07-01 |
| IE40585L (en) | 1975-08-06 |
| AT335439B (en) | 1977-03-10 |
| GB1449586A (en) | 1976-09-15 |
| DD120015A5 (en) | 1976-05-20 |
| AR203228A1 (en) | 1975-08-22 |
| IE40585B1 (en) | 1979-07-04 |
| NL7501220A (en) | 1975-08-08 |
| DK36575A (en) | 1975-10-06 |
| HU169491B (en) | 1976-12-28 |
| BE825176A (en) | 1975-08-04 |
| SE7501083L (en) | 1975-08-07 |
| FR2259597B1 (en) | 1980-01-04 |
| ATA85775A (en) | 1976-07-15 |
| ZA75703B (en) | 1976-02-25 |
| JPS50108249A (en) | 1975-08-26 |
| DE2405622A1 (en) | 1975-08-14 |
| CA1043806A (en) | 1978-12-05 |
| FR2259597A1 (en) | 1975-08-29 |
| FI750292A (en) | 1975-08-07 |
| SU674670A3 (en) | 1979-07-15 |
| IL46543A0 (en) | 1975-04-25 |
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