ES428798A1 - Procedimiento de fabricacion de la metilcobalamina a partir de la cianocobalamina. - Google Patents
Procedimiento de fabricacion de la metilcobalamina a partir de la cianocobalamina.Info
- Publication number
- ES428798A1 ES428798A1 ES428798A ES428798A ES428798A1 ES 428798 A1 ES428798 A1 ES 428798A1 ES 428798 A ES428798 A ES 428798A ES 428798 A ES428798 A ES 428798A ES 428798 A1 ES428798 A1 ES 428798A1
- Authority
- ES
- Spain
- Prior art keywords
- cyanocobalamin
- methylcobalamin
- methylation
- solution
- methyl acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 abstract 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 235000000639 cyanocobalamin Nutrition 0.000 abstract 3
- 239000011666 cyanocobalamin Substances 0.000 abstract 3
- 229960002104 cyanocobalamin Drugs 0.000 abstract 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 230000011987 methylation Effects 0.000 abstract 2
- 238000007069 methylation reaction Methods 0.000 abstract 2
- 235000007672 methylcobalamin Nutrition 0.000 abstract 2
- 239000011585 methylcobalamin Substances 0.000 abstract 2
- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7328998A FR2240232A1 (en) | 1973-08-08 | 1973-08-08 | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
| FR7346829A FR2256174A2 (en) | 1973-12-28 | 1973-12-28 | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES428798A1 true ES428798A1 (es) | 1976-09-16 |
Family
ID=26217885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES428798A Expired ES428798A1 (es) | 1973-08-08 | 1974-07-31 | Procedimiento de fabricacion de la metilcobalamina a partir de la cianocobalamina. |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5727119B2 (de) |
| AR (1) | AR199756A1 (de) |
| CA (1) | CA1019726A (de) |
| CH (1) | CH583744A5 (de) |
| DE (1) | DE2434967A1 (de) |
| DK (1) | DK136775B (de) |
| ES (1) | ES428798A1 (de) |
| GB (1) | GB1419933A (de) |
| IE (1) | IE41823B1 (de) |
| IL (1) | IL45384A (de) |
| IN (1) | IN139935B (de) |
| LU (1) | LU70582A1 (de) |
| NL (1) | NL7410061A (de) |
| NO (1) | NO742545L (de) |
| OA (1) | OA04753A (de) |
| SE (1) | SE412589B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2151773C1 (ru) * | 1999-03-10 | 2000-06-27 | Казанский государственный университет им. В.И. Ульянова-Ленина | ТЕТРАКИС-(L-ГИСТИДИНАТО)-μ-ПЕРОКСИДИКОБАЛЬТА (III) ГЕПТАГИДРАТ, ПРОЯВЛЯЮЩИЙ АНТИАНЕМИЧЕСКУЮ, РАДИОПРОТЕКТОРНУЮ И АНТИАРИТМИЧЕСКУЮ АКТИВНОСТЬ |
| ES2558679T3 (es) | 2001-06-05 | 2016-02-08 | Eisai R&D Management Co., Ltd. | Procedimiento para producir metilcobalamina |
| CN102391340A (zh) * | 2011-10-31 | 2012-03-28 | 河北玉星生物工程有限公司 | 一种甲钴胺的制备方法 |
| JP6867409B2 (ja) * | 2016-07-08 | 2021-04-28 | ヘルステック バイオ アクティブズ，エス．エル．ユー | メチルコバラミンの精製方法 |
| CN114874276B (zh) * | 2022-04-21 | 2024-06-21 | 南京工业大学 | 一种改进的合成甲钴胺的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789252A (fr) * | 1971-11-10 | 1973-03-26 | Boige Jean | Procede de fabrication de la methylcobalamine |
-
1974
- 1974-07-12 NO NO742545A patent/NO742545L/no unknown
- 1974-07-17 DK DK386274AA patent/DK136775B/da unknown
- 1974-07-19 DE DE2434967A patent/DE2434967A1/de active Pending
- 1974-07-22 LU LU70582A patent/LU70582A1/xx unknown
- 1974-07-23 CA CA205,451A patent/CA1019726A/en not_active Expired
- 1974-07-24 IN IN1642/CAL/74A patent/IN139935B/en unknown
- 1974-07-25 NL NL7410061A patent/NL7410061A/xx unknown
- 1974-07-26 AR AR254903A patent/AR199756A1/es active
- 1974-07-26 OA OA55258A patent/OA04753A/xx unknown
- 1974-07-29 CH CH1040374A patent/CH583744A5/xx not_active IP Right Cessation
- 1974-07-31 ES ES428798A patent/ES428798A1/es not_active Expired
- 1974-08-01 GB GB3400874A patent/GB1419933A/en not_active Expired
- 1974-08-02 SE SE7410005A patent/SE412589B/xx unknown
- 1974-08-02 IL IL45384A patent/IL45384A/xx unknown
- 1974-08-06 IE IE1654/74A patent/IE41823B1/en unknown
- 1974-08-07 JP JP8995074A patent/JPS5727119B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO742545L (de) | 1975-03-10 |
| CA1019726A (en) | 1977-10-25 |
| CH583744A5 (de) | 1977-01-14 |
| AU7188674A (en) | 1976-02-05 |
| DK386274A (de) | 1975-04-01 |
| SE412589B (sv) | 1980-03-10 |
| NL7410061A (nl) | 1975-02-11 |
| IL45384A0 (en) | 1974-11-29 |
| JPS5727119B2 (de) | 1982-06-08 |
| LU70582A1 (de) | 1976-05-31 |
| JPS5041900A (de) | 1975-04-16 |
| AR199756A1 (es) | 1974-09-23 |
| IE41823B1 (en) | 1980-04-09 |
| IE41823L (en) | 1975-02-08 |
| OA04753A (fr) | 1980-08-31 |
| DK136775C (de) | 1978-05-08 |
| IN139935B (de) | 1976-08-21 |
| DK136775B (da) | 1977-11-21 |
| SE7410005L (de) | 1975-02-10 |
| IL45384A (en) | 1976-09-30 |
| DE2434967A1 (de) | 1975-02-20 |
| GB1419933A (en) | 1975-12-31 |
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