ES428798A1 - Preparation of methylcobalamine - Google Patents
Preparation of methylcobalamineInfo
- Publication number
- ES428798A1 ES428798A1 ES428798A ES428798A ES428798A1 ES 428798 A1 ES428798 A1 ES 428798A1 ES 428798 A ES428798 A ES 428798A ES 428798 A ES428798 A ES 428798A ES 428798 A1 ES428798 A1 ES 428798A1
- Authority
- ES
- Spain
- Prior art keywords
- cyanocobalamin
- methylcobalamin
- methylation
- solution
- methyl acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Method of manufacturing methylcobalamin from cyanocobalamin, in which the methylation of a reduced cobalamin is carried out, characterized in that a solution is prepared containing at least 40 g per liter of cyanocobalamin in a mixture of methanol and water, for that is added to this solution methyl acid oxalate and a metallic powder capable of releasing hydrogen by ion onto the methyl acid oxalate, in order to simultaneously perform the reduction of the cyanocobalamin and the methylation of the reduced cobalamin in methylcobalamin. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7328998A FR2240232A1 (en) | 1973-08-08 | 1973-08-08 | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
| FR7346829A FR2256174A2 (en) | 1973-12-28 | 1973-12-28 | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES428798A1 true ES428798A1 (en) | 1976-09-16 |
Family
ID=26217885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES428798A Expired ES428798A1 (en) | 1973-08-08 | 1974-07-31 | Preparation of methylcobalamine |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5727119B2 (en) |
| AR (1) | AR199756A1 (en) |
| CA (1) | CA1019726A (en) |
| CH (1) | CH583744A5 (en) |
| DE (1) | DE2434967A1 (en) |
| DK (1) | DK136775B (en) |
| ES (1) | ES428798A1 (en) |
| GB (1) | GB1419933A (en) |
| IE (1) | IE41823B1 (en) |
| IL (1) | IL45384A (en) |
| IN (1) | IN139935B (en) |
| LU (1) | LU70582A1 (en) |
| NL (1) | NL7410061A (en) |
| NO (1) | NO742545L (en) |
| OA (1) | OA04753A (en) |
| SE (1) | SE412589B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2449480C (en) | 2001-06-05 | 2009-07-21 | Eisai Co., Ltd. | Process for producing methylcobalamin |
| CN102391340A (en) * | 2011-10-31 | 2012-03-28 | 河北玉星生物工程有限公司 | Preparation method of mecobalamin |
| HUE063127T2 (en) | 2016-07-08 | 2024-01-28 | Healthtech Bio Actives S L U | Process for the purification of methylcobalamin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789252A (en) * | 1971-11-10 | 1973-03-26 | Boige Jean | METHOD FOR MANUFACTURING METHYLCOBALAMINE |
-
1974
- 1974-07-12 NO NO742545A patent/NO742545L/no unknown
- 1974-07-17 DK DK386274AA patent/DK136775B/en unknown
- 1974-07-19 DE DE2434967A patent/DE2434967A1/en active Pending
- 1974-07-22 LU LU70582A patent/LU70582A1/xx unknown
- 1974-07-23 CA CA205,451A patent/CA1019726A/en not_active Expired
- 1974-07-24 IN IN1642/CAL/74A patent/IN139935B/en unknown
- 1974-07-25 NL NL7410061A patent/NL7410061A/en unknown
- 1974-07-26 OA OA55258A patent/OA04753A/en unknown
- 1974-07-26 AR AR254903A patent/AR199756A1/en active
- 1974-07-29 CH CH1040374A patent/CH583744A5/xx not_active IP Right Cessation
- 1974-07-31 ES ES428798A patent/ES428798A1/en not_active Expired
- 1974-08-01 GB GB3400874A patent/GB1419933A/en not_active Expired
- 1974-08-02 IL IL45384A patent/IL45384A/en unknown
- 1974-08-02 SE SE7410005A patent/SE412589B/en unknown
- 1974-08-06 IE IE1654/74A patent/IE41823B1/en unknown
- 1974-08-07 JP JP8995074A patent/JPS5727119B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK136775B (en) | 1977-11-21 |
| IE41823B1 (en) | 1980-04-09 |
| LU70582A1 (en) | 1976-05-31 |
| GB1419933A (en) | 1975-12-31 |
| CH583744A5 (en) | 1977-01-14 |
| IL45384A (en) | 1976-09-30 |
| IL45384A0 (en) | 1974-11-29 |
| DK136775C (en) | 1978-05-08 |
| NO742545L (en) | 1975-03-10 |
| JPS5727119B2 (en) | 1982-06-08 |
| CA1019726A (en) | 1977-10-25 |
| NL7410061A (en) | 1975-02-11 |
| AR199756A1 (en) | 1974-09-23 |
| AU7188674A (en) | 1976-02-05 |
| OA04753A (en) | 1980-08-31 |
| JPS5041900A (en) | 1975-04-16 |
| SE412589B (en) | 1980-03-10 |
| DE2434967A1 (en) | 1975-02-20 |
| IE41823L (en) | 1975-02-08 |
| DK386274A (en) | 1975-04-01 |
| SE7410005L (en) | 1975-02-10 |
| IN139935B (en) | 1976-08-21 |
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