ES427722A1 - Method for the preparation of codeinone from tebaina. (Machine-translation by Google Translate, not legally binding) - Google Patents

Method for the preparation of codeinone from tebaina. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES427722A1
ES427722A1 ES74427722A ES427722A ES427722A1 ES 427722 A1 ES427722 A1 ES 427722A1 ES 74427722 A ES74427722 A ES 74427722A ES 427722 A ES427722 A ES 427722A ES 427722 A1 ES427722 A1 ES 427722A1
Authority
ES
Spain
Prior art keywords
codeinone
thebaine
translation
preparation
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES74427722A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QUIM FAB DE PROD
Laboratorios Abello SA
Original Assignee
QUIM FAB DE PROD
Laboratorios Abello SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QUIM FAB DE PROD, Laboratorios Abello SA filed Critical QUIM FAB DE PROD
Priority to ES74427722A priority Critical patent/ES427722A1/en
Priority to BE165304A priority patent/BE839732A/en
Publication of ES427722A1 publication Critical patent/ES427722A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Method for the preparation of codeinone from thebaine, characterized by reacting, with the intervention of iodine as catalyst, thebaine dissolved in methylene chloride with hydrobromic acid in di-N-butyl ether, in anhydrous medium and at lower temperatures at 10º c, with subsequent hydrolysis of the compound formed in a mild alkaline sodium bicarbonate medium, and then extraction with methylene chloride and obtaining the codeinone by evaporation of the solvent. This general method is extended and covers the specific cases that derive from the use of different halogenhydric acids, as halogenating agents, different chlorinated compounds, to dissolve the thebaine and different ethers to dissolve the hydrogen halide acid. (Machine-translation by Google Translate, not legally binding)
ES74427722A 1974-06-24 1974-06-24 Method for the preparation of codeinone from tebaina. (Machine-translation by Google Translate, not legally binding) Expired ES427722A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES74427722A ES427722A1 (en) 1974-06-24 1974-06-24 Method for the preparation of codeinone from tebaina. (Machine-translation by Google Translate, not legally binding)
BE165304A BE839732A (en) 1974-06-24 1976-03-18 CODEINONE SYNTHESIS PROCESS FROM THEBAINE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES74427722A ES427722A1 (en) 1974-06-24 1974-06-24 Method for the preparation of codeinone from tebaina. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES427722A1 true ES427722A1 (en) 1976-08-01

Family

ID=8467038

Family Applications (1)

Application Number Title Priority Date Filing Date
ES74427722A Expired ES427722A1 (en) 1974-06-24 1974-06-24 Method for the preparation of codeinone from tebaina. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
BE (1) BE839732A (en)
ES (1) ES427722A1 (en)

Also Published As

Publication number Publication date
BE839732A (en) 1976-07-16

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