ES426206A1 - 2-aminothiazole derivatives - Google Patents

2-aminothiazole derivatives

Info

Publication number
ES426206A1
ES426206A1 ES426206A ES426206A ES426206A1 ES 426206 A1 ES426206 A1 ES 426206A1 ES 426206 A ES426206 A ES 426206A ES 426206 A ES426206 A ES 426206A ES 426206 A1 ES426206 A1 ES 426206A1
Authority
ES
Spain
Prior art keywords
formula
attached
atom
nitrogen
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES426206A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRE ETD IND PHARMA
Centre dEtudes pour lIndustrie Pharmaceutique
Original Assignee
CENTRE ETD IND PHARMA
Centre dEtudes pour lIndustrie Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CENTRE ETD IND PHARMA, Centre dEtudes pour lIndustrie Pharmaceutique filed Critical CENTRE ETD IND PHARMA
Publication of ES426206A1 publication Critical patent/ES426206A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Preparation procedure of derivatives of formula: ** (See formula) ** where E is a group of formula: ** (See formula) ** attached to the sulfur atom by its second carbon atom, R1 and R2, identical or different from each other, are hydrogen or radicals, optionally halogenated and/or hydroxylated, alkenyl, alkoxy, cycloalloxy, aryl, or arylalkyl, or form, together with the nitrogen atom to which they are attached, a saturated heterocycle with 4 to 8 rings, possibly having the second heteroatom, a nitrogen, sulfur or oxygen atom and possibly substituted by an alcohol, and R1 and R4, identical or different from each other, are hydrogen, alcoholic, or cycloalkyl, or form, together with the nitrogen atom to which they are attached, a saturated heterocycle of 5 or 6 rings, possibly having an oxygen or nitrogen heteroatom, being able The latter nitrogen heteroatom bears an aryl, optionally substituted by a halogen, by a trifluoromethyl or by an optionally halogenated and/or hydroxylated alcohol or alkoxy radical, characterized in that consists of reacting an amine AH on an isothiocyanate BN = C = S, where A is -H (R1-R2) when B is -CH2-RO-CH2-N (R3R4) and, with the proviso that R2 is hydrogen, where N (R3R4) -CH2-RO-CH2-NH- when B is R1-, where RO is the vinylene radical -CH = CH- or ethylene -C C-, to form the transient compound of formula: ** (See formula) ** then, by heating in an acidic medium, in cyclizing this transitory compound in the thiazolinic derivative of formula: ** (See formula) ** wherein R is the saturated trivalent radical, when RO is vinyl, or is the unsaturated trivalent radical attached to the nitrogen atom by its carbon atom not adjacent to its double bond, when RO is ethynylene, and, to prepare the thiazole derivative of formula (I) in which R is attached to the nitrogen atom by its carbon atom adjacent to its double bond to isomerize the derivative (Ia) in which R has a double bond. (Machine-translation by Google Translate, not legally binding)
ES426206A 1973-05-16 1974-05-11 2-aminothiazole derivatives Expired ES426206A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7317698A FR2247234B1 (en) 1973-05-16 1973-05-16

Publications (1)

Publication Number Publication Date
ES426206A1 true ES426206A1 (en) 1976-07-01

Family

ID=9119403

Family Applications (1)

Application Number Title Priority Date Filing Date
ES426206A Expired ES426206A1 (en) 1973-05-16 1974-05-11 2-aminothiazole derivatives

Country Status (19)

Country Link
JP (1) JPS5030888A (en)
AT (1) AT334894B (en)
BE (1) BE814579A (en)
CA (1) CA1057292A (en)
CH (1) CH595364A5 (en)
DD (1) DD112268A5 (en)
DE (1) DE2423403A1 (en)
ES (1) ES426206A1 (en)
FR (1) FR2247234B1 (en)
GB (1) GB1456257A (en)
HU (1) HU169176B (en)
IL (1) IL44845A (en)
NL (1) NL7406490A (en)
PL (1) PL91265B1 (en)
RO (1) RO66055A (en)
SE (1) SE429653B (en)
SU (1) SU535906A3 (en)
YU (1) YU36712B (en)
ZA (1) ZA743048B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018786A (en) * 1974-08-06 1977-04-19 Centre D'etudes Pour L'industrie Pharmaceutique 2-Aminothiazolines and a process for preparation thereof
GB2550950B (en) * 2016-06-02 2021-03-10 Dixon Barnaby Puppet

Also Published As

Publication number Publication date
AU6889574A (en) 1975-11-20
IL44845A (en) 1977-06-30
IL44845A0 (en) 1974-07-31
AT334894B (en) 1977-02-10
DE2423403A1 (en) 1974-12-05
GB1456257A (en) 1976-11-24
FR2247234A1 (en) 1975-05-09
ZA743048B (en) 1975-05-28
SE429653B (en) 1983-09-19
YU36712B (en) 1984-08-31
YU133274A (en) 1982-06-18
ATA403574A (en) 1976-06-15
RO66055A (en) 1981-07-30
CA1057292A (en) 1979-06-26
FR2247234B1 (en) 1977-01-21
NL7406490A (en) 1974-11-19
BE814579A (en) 1974-09-02
PL91265B1 (en) 1977-02-28
SU535906A3 (en) 1976-11-15
JPS5030888A (en) 1975-03-27
DD112268A5 (en) 1975-04-05
HU169176B (en) 1976-10-28
CH595364A5 (en) 1978-02-15

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