ES424356A1 - Procedure for the obtaining of pyridacine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for obtaining pyridazine derivatives of formula I **(See formula)** wherein R1 signifies an alkyl radical of 1 to 4 carbon atoms, R 3, R4, R5 and R6 are the same or different and each signifies a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, or each de R3 and R6 signifies a hydrogen atom and R4, and R5 together signify a radical - (CH2) n-, where n signifies 2, 3 or 4, and R2 signifies a thienyl, furyl to pyridyl radical, or a radical of formula II, **(See formula)** wherein each of R7 and R11 signifies a hydrogen, fluorine, or chlorine atom, or a straight-chain alkyl radical containing 1 to 4 carbon atoms, and each of R8, R9, and R10, which may be the same or different, it means a hydrogen atom, that at least three of R7, R8, R9, and R10 mean a hydrogen atom, and that R9 does not mean a trifluoromethyl group when R8 or R10 means a trifluoromethyl group, characterized by that it reacts a compound of formula V, **(See formula)** wherein R2, R3, R4, R5 and R6 have the meanings indicated above, and M is an alkali metal, with a compound of formula VI, **(See formula)** where R1 has the meaning indicated above, and X means a chlorine or bromine atom and Y means a hydroxy group, or X and Y together means the group -O-, in an inert solvent, for example dimethylformamide, dimethyl acetamide, or an aromatic or aliphatic hydrocarbon, and at a temperature not exceeding 50ºC, preferably 15 to 30ºC. (Machine-translation by Google Translate, not legally binding)