ES424067A1 - Procedimiento de preparacion de dihidro - 5,6 (4h) - (s) - triazolo - (3,3 - a) - benzodiazepinas - 1,5. - Google Patents

Procedimiento de preparacion de dihidro - 5,6 (4h) - (s) - triazolo - (3,3 - a) - benzodiazepinas - 1,5.

Info

Publication number
ES424067A1
ES424067A1 ES424067A ES424067A ES424067A1 ES 424067 A1 ES424067 A1 ES 424067A1 ES 424067 A ES424067 A ES 424067A ES 424067 A ES424067 A ES 424067A ES 424067 A1 ES424067 A1 ES 424067A1
Authority
ES
Spain
Prior art keywords
disclosed
class
triazolobenzodiazepines
benzodiazepines
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424067A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7308510A external-priority patent/FR2220257A1/fr
Priority claimed from FR7335522A external-priority patent/FR2246273A2/fr
Priority claimed from FR7341583A external-priority patent/FR2252102A2/fr
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Publication of ES424067A1 publication Critical patent/ES424067A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES424067A 1973-03-09 1974-03-08 Procedimiento de preparacion de dihidro - 5,6 (4h) - (s) - triazolo - (3,3 - a) - benzodiazepinas - 1,5. Expired ES424067A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7308510A FR2220257A1 (en) 1973-03-09 1973-03-09 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects
FR7335522A FR2246273A2 (en) 1973-10-04 1973-10-04 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects
FR7341583A FR2252102A2 (en) 1973-11-22 1973-11-22 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects

Publications (1)

Publication Number Publication Date
ES424067A1 true ES424067A1 (es) 1976-06-01

Family

ID=27250074

Family Applications (1)

Application Number Title Priority Date Filing Date
ES424067A Expired ES424067A1 (es) 1973-03-09 1974-03-08 Procedimiento de preparacion de dihidro - 5,6 (4h) - (s) - triazolo - (3,3 - a) - benzodiazepinas - 1,5.

Country Status (13)

Country Link
US (1) US4110337A (es)
JP (1) JPS49125395A (es)
CA (1) CA1011333A (es)
CH (1) CH589084A5 (es)
DD (1) DD110497A5 (es)
DE (1) DE2409308C3 (es)
DK (1) DK139099B (es)
ES (1) ES424067A1 (es)
GB (1) GB1409693A (es)
IE (1) IE38931B1 (es)
IL (1) IL44338A (es)
NL (1) NL7403247A (es)
NO (1) NO139048C (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076823A (en) * 1977-08-18 1978-02-28 E. R. Squibb & Sons, Inc. Triazolo-2,4-benzodiazepines
AU654548B2 (en) * 1991-04-23 1994-11-10 Toray Industries, Inc. Tricyclic triazole derivative, production thereof, and use thereof
US5683998A (en) * 1991-04-23 1997-11-04 Toray Industries, Inc. Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
FR2769309B1 (fr) 1997-10-08 2001-06-15 Oreal Composition de teinture d'oxydation des fibres keratiniques comprenant un derive d'aminoacide en tant que base d'oxydation et nouveaux derives d'aminoacides
US7144880B2 (en) * 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US20060025388A1 (en) * 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US20030119029A1 (en) * 1999-04-30 2003-06-26 Regents Of The University Of Michigan Compositions and methods relating to novel benzodiazepine compounds and targets thereof
US7276348B2 (en) * 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
DE60007960T2 (de) 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
JP2008528448A (ja) * 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 新規化合物に関連する組成物および方法、ならびにその標的
AU2006309291B2 (en) * 2005-06-01 2010-05-27 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
US8088759B2 (en) 2005-11-01 2012-01-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
DE102005061840A1 (de) * 2005-12-23 2007-06-28 Merck Patent Gmbh Triazolderivate
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2037741B1 (en) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders
BRPI0808653A2 (pt) 2007-03-09 2014-08-19 Univ Michigan Composições e métodos referindo-se a novos compostos e alvos dos mesmos.
CA2698248C (en) 2007-09-14 2017-08-29 The Regents Of The University Of Michigan Phenyl acyl guanidine derivatives as f1f0-atpase inhibitors and the use thereof
JP5539212B2 (ja) 2007-11-06 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 皮膚症状の治療に有用なベンゾジアゼピノン化合物
EP2352724B1 (en) 2008-09-11 2015-04-22 The Regents of the University of Michigan Aryl guanidine f1f0-atpase inhibitors and their medical use
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
CA2915237C (en) 2009-11-17 2017-10-10 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
AU2010322287B2 (en) 2009-11-17 2014-04-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
CA2952830C (en) 2014-06-20 2022-11-01 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681343A (en) * 1971-05-11 1972-08-01 Upjohn Co 6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines

Also Published As

Publication number Publication date
IE38931L (en) 1974-09-09
NO139048B (no) 1978-09-18
GB1409693A (en) 1975-10-15
US4110337A (en) 1978-08-29
NL7403247A (es) 1974-09-11
CA1011333A (en) 1977-05-31
DD110497A5 (es) 1974-12-20
NO139048C (no) 1979-01-03
DE2409308C3 (de) 1978-05-18
IE38931B1 (en) 1978-07-05
IL44338A (en) 1977-01-31
NO740833L (no) 1974-09-10
AU6627674A (en) 1975-09-11
DK139099C (es) 1979-05-28
JPS49125395A (es) 1974-11-30
DK139099B (da) 1978-12-18
DE2409308A1 (de) 1974-09-19
CH589084A5 (es) 1977-06-30
IL44338A0 (en) 1974-06-30
DE2409308B2 (de) 1977-09-22

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