ES419506A1 - Un procedimiento para la preparacion de nuevos acidos (1- oxo-2, 3-hidrocarbilen-5-indaniloxi) alcanoico. - Google Patents

Un procedimiento para la preparacion de nuevos acidos (1- oxo-2, 3-hidrocarbilen-5-indaniloxi) alcanoico.

Info

Publication number
ES419506A1
ES419506A1 ES419506A ES419506A ES419506A1 ES 419506 A1 ES419506 A1 ES 419506A1 ES 419506 A ES419506 A ES 419506A ES 419506 A ES419506 A ES 419506A ES 419506 A1 ES419506 A1 ES 419506A1
Authority
ES
Spain
Prior art keywords
indanyloxy
hydrocarbylene
thio
oxo
alkanoic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES419506A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA178,825A external-priority patent/CA1027581A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES419506A1 publication Critical patent/ES419506A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
ES419506A 1972-10-13 1973-10-09 Un procedimiento para la preparacion de nuevos acidos (1- oxo-2, 3-hidrocarbilen-5-indaniloxi) alcanoico. Expired ES419506A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA153921 1972-10-13
CA178,825A CA1027581A (en) 1973-08-28 1973-08-28 (1-oxo-2,3-hydrocarbylene-5-indanyloxy (or thio)) alkanoic acids

Publications (1)

Publication Number Publication Date
ES419506A1 true ES419506A1 (es) 1976-12-16

Family

ID=25667130

Family Applications (1)

Application Number Title Priority Date Filing Date
ES419506A Expired ES419506A1 (es) 1972-10-13 1973-10-09 Un procedimiento para la preparacion de nuevos acidos (1- oxo-2, 3-hidrocarbilen-5-indaniloxi) alcanoico.

Country Status (11)

Country Link
US (1) US3976686A (es)
JP (1) JPS581096B2 (es)
CH (1) CH605555A5 (es)
DE (1) DE2351411C2 (es)
DK (1) DK146444C (es)
ES (1) ES419506A1 (es)
FR (1) FR2202694B1 (es)
GB (1) GB1427090A (es)
HU (1) HU169581B (es)
NL (1) NL7314105A (es)
SE (1) SE412383B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4085219A (en) * 1972-10-13 1978-04-18 Merck & Co., Inc. 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids
WO1995000468A1 (en) * 1993-06-18 1995-01-05 Otsuka Pharmaceutical Co., Ltd. Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
WO2014099676A1 (en) 2012-12-17 2014-06-26 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9206151B2 (en) * 2013-11-20 2015-12-08 Transitions Optical, Inc. Method of preparing fused ring indeno compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344742B (es) * 1968-09-25 1972-05-02 Ciba Geigy Ag
US3668241A (en) * 1968-11-25 1972-06-06 Merck & Co Inc Substituted 1-oxoinden-5-yloxy alkanoic acids
CH517064A (de) * 1969-07-09 1971-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Aryloxy- und Arylthioessigsäurederivaten
DE2208893A1 (de) * 1972-02-25 1973-08-30 Boehringer Mannheim Gmbh Tricyclische alpha-oxy-carbonsaeurederivate und verfahren zur herstellung derselben

Also Published As

Publication number Publication date
NL7314105A (es) 1974-04-16
HU169581B (es) 1976-12-28
JPS4993352A (es) 1974-09-05
SE412383B (sv) 1980-03-03
DK146444B (da) 1983-10-10
DE2351411A1 (de) 1974-04-25
AU6096773A (en) 1975-04-10
US3976686A (en) 1976-08-24
FR2202694B1 (es) 1977-01-28
CH605555A5 (es) 1978-09-29
JPS581096B2 (ja) 1983-01-10
DK146444C (da) 1984-03-19
DE2351411C2 (de) 1983-04-21
FR2202694A1 (es) 1974-05-10
GB1427090A (en) 1976-03-03

Similar Documents

Publication Publication Date Title
HU175875B (en) Process for producing 4-bracket-monoalkyl-amino-bracket closed-benzoic acids, esters and pharmaceutically acceptable salts thereof, and pharmaceutical compositions of hypolipidemic activity containing them as active agents
ZA761118B (en) 1,4-dihydropyridine-carboxylic acid aralkyl esters,processes for their preparations and their use as medicaments
IL42044A0 (en) New 1,4-dihydropyridine carboxylic acid esters,their production and pharmaceutical compositions containing them
HK19481A (en) 3,4-dihydrocarbostyril derivatives,their preparation,and pharmaceutical compositions thereof
IL50347A (en) Heteroarylbenzoxepin acetic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them
NZ179835A (en) Aminoalkynoic acids,derivatives and pharmaceutical compositions
ES419505A1 (es) Un procedimiento de preparacion de acidos 1-oxo-5-indaniloxi(o tio) alcanoicos 2, 2-disustituidos.
ES419506A1 (es) Un procedimiento para la preparacion de nuevos acidos (1- oxo-2, 3-hidrocarbilen-5-indaniloxi) alcanoico.
IL43570A0 (en) Aroyl-substituted phenylacetic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them
GR60385B (en) New propargyl-2-phenylamino-imidazolines-(2),salts thereof by addition of their acids,pharmaceutical mediums containing the above and process for their preparation
IL41220A0 (en) Thioxanthone-2-carboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them
AU471079B2 (en) 5, 9, 13-prostatrienoic acid derivatives and process for their preparation
AU476339B2 (en) Halo-4-biphenylyl-butyric acids, esters and amides and pharmaceutical compositions containing them
AU3784072A (en) A process for the preparation of new complexes of biologically active peptides, polypetrides, proteins or derivatives or salts thereof having prolonged and/or increased activity
ZA733012B (en) New acylamino acids and their derivatives and process for preparing them and pharmaceutical compositions
IL55006A (en) Oxaminic acids and salts and esters thereof,their production and pharmaceutical compositions containing them
PH22225A (en) ((1-oxo-2-aryl or thionyl-2-substituted-5-endanyl-oxy (or thio)) alkanaoic acids and derivatives thereof, pharmaceutical composition and method of use
IL40623A (en) 14,15-dihydro-eburnamine-14-carboxylic acid derivatives and salts thereof,their preparation and pharmaceutical compositions containing them
ZA733638B (en) New heterocyclic derivatives preparation process and pharmaceutical compositions
IL50166A (en) 7 -(d-2-amino-(1,4-cyclohexadienyl)-acetylamino)-3-hal-3-cephem-4-carboxylic acids their preparation and pharmaceutical compositions containing them
IL43284A0 (en) New derivatives of 3-amino-5-sulfamoyl-benzoic acid,their manufacture and pharmaceutical preparations containing the
PH11435A (en) 7 b-acylamidoceph-3em-4-carboxylic acid derivatives and pharmaceutical compositions containing same
CA890944A (en) Process for the preparation of aliphatic perfluoro-carboxylic acids and the derivatives thereof
AU474109B2 (en) Thiazole carboxylic acid derivatives, process forthe preparation thereof and pharmaceutical compositions containing same
CA866853A (en) 3,4,5-trimethoxy-benzamido alkanoic acids and their pharmaceutically acceptable salts