ES417506A1 - Method for the obtaining of pharmacologically active isotophylines. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Method for the obtaining of pharmacologically active isotophylines. (Machine-translation by Google Translate, not legally binding)
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Lacer SA
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Lacer SA
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Priority to ES417506ApriorityCriticalpatent/ES417506A1/en
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
Method for obtaining pharmacologically active isotheophyllines, particularly 9- (beta-aminoethyl) -isoteophyllins, of the general formula: **(See formula)** wherein R1 and R2 are hydrogen atoms, alkyl, hydroxyalkyl radicals or, together with the nitrogen atom, a substituted or unsubstituted heterocyclic moiety that may in turn contain another heteroatom, characterized in that from 1,3-dimethyl- 4,5-diaminouracils, suitably substituted, is operated by condensation of 1,3-dimethyl-4- (beta-hydroxyethylamino) -5-aminouracil with formic acid orthoesters and cyclization and then transforming 9- (beta-hydroxyethyl) - isoteophylline with inorganic acid halides to 9- (beta-halogenoethyl) -isoteophilins, which are then reacted with amines of the general formula: **(See formula)** where R1 and R2 have the meaning mentioned above. (Machine-translation by Google Translate, not legally binding)
ES417506A1973-08-021973-08-02Method for the obtaining of pharmacologically active isotophylines. (Machine-translation by Google Translate, not legally binding)
ExpiredES417506A1
(en)
Procedure for the obtaining of substitute 4-oxo-3-amino-3,4-dihydrotean (3,2-d) pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding)