ES409590A1 - A procedure for preparation of cefalosporine compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for preparation of cefalosporine compounds. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES409590A1
ES409590A1 ES409590A ES409590A ES409590A1 ES 409590 A1 ES409590 A1 ES 409590A1 ES 409590 A ES409590 A ES 409590A ES 409590 A ES409590 A ES 409590A ES 409590 A1 ES409590 A1 ES 409590A1
Authority
ES
Spain
Prior art keywords
formula
hydrogen
thiocarbamoyloxy
carbamoyloxy
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES409590A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES409590A1 publication Critical patent/ES409590A1/en
Expired legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

A method of preparing cephalosporin compounds of the formula: **(See formula)** where X is hydrogen, amino or carboxyl; R is phenyl or a 5-membered ring containing one or two heteroatoms, the latter being sulfur, oxygen or nitrogen; A is hydrogen, lower alkanoyl oxy, carbamoyloxy, thiocarbamoyloxy, N-lower alkyl carbamoyloxy, N-lower alkyl thiocarbamoyloxy, N, N-dialkyl lower carbamoyloxy, N, N-dialkyl lower thiocarbamoyloxy, pyridinium, alkylpyridinium, halopyridinium or aminopyridinium and N is sodium, potassium, benzyl, benzohydryl, trimethylsilyl, trichlorethyl, methoxymethyl, hydrogen, benzoylmethyl or methoxybenzyl; whose procedure is to acylate the compound of formula: **(See formula)** where the radicals M'are the same or different and each represents benzohydryl, trimethylsilyl, trichlorethyl, methoxymethyl, benzoylmethyl, methoxybenzyl or benzyl; the acylating agent consists of a substituted acetic acid halide or anhydride of the formula: **(See formula)** where R and X are as defined above and X'is halogen or (see formula); followed by removal of blocking group M'when M is hydrogen or removal of blocking group M' followed by addition of an alkali metal hydroxide when M is sodium or potassium. (Machine-translation by Google Translate, not legally binding)
ES409590A 1971-12-16 1972-12-13 A procedure for preparation of cefalosporine compounds. (Machine-translation by Google Translate, not legally binding) Expired ES409590A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20894271A 1971-12-16 1971-12-16

Publications (1)

Publication Number Publication Date
ES409590A1 true ES409590A1 (en) 1976-01-01

Family

ID=22776688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES409590A Expired ES409590A1 (en) 1971-12-16 1972-12-13 A procedure for preparation of cefalosporine compounds. (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
JP (1) JPS4867294A (en)
CA (1) CA992072A (en)
DD (1) DD101682A5 (en)
ES (1) ES409590A1 (en)
NL (1) NL7216202A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906592B2 (en) * 2008-07-03 2011-03-15 Bridgestone Corporation Polymers functionalized with imide compounds containing a protected amino group

Also Published As

Publication number Publication date
CA992072A (en) 1976-06-29
DD101682A5 (en) 1973-11-12
NL7216202A (en) 1973-06-19
JPS4867294A (en) 1973-09-13

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