ES409089A1 - Benzodizepines - Google Patents
BenzodizepinesInfo
- Publication number
- ES409089A1 ES409089A1 ES409089A ES409089A ES409089A1 ES 409089 A1 ES409089 A1 ES 409089A1 ES 409089 A ES409089 A ES 409089A ES 409089 A ES409089 A ES 409089A ES 409089 A1 ES409089 A1 ES 409089A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- molecular weight
- low molecular
- atom
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Procedure for the preparation of compounds of the general formula **(See formula)** where the symbols have the following meanings: R1 means a halogen atom; R2 and R3, which are the same or different, signify hydrogen, halogen atoms, the trifluoromethyl group, the nitro group, the nitrile group, the hydroxy group, low molecular weight alcohol groups or low molecular weight alkoxy groups; R4 means a hydrogen atom, a hydroxy group, a hydroxy group acylated by aliphatic monocarboxylic or dicarboxylic acids with 2 to 6 carbon atoms, a low molecular weight alkoxy group, a low molecular weight alcohol group, a benzyl group, a low molecular weight aliphatic acyl group, a carboxy group or a low molecular weight carboalkoxy group; Z signifies a nitrogen atom or the group NO; R5 signifies a hydrogen atom, a low molecular weight alcohol group optionally substituted by a cycloalcoyl radical with 3 to 6 carbon atoms, a low molecular weight alkenyl group, a cycloalcoyl group of 3 to 6 carbon atoms, a hydroxyalkyl group low molecular weight, a benzyl group, an aliphatic acyl group with 2 to 6 carbon atoms or an aminoalcohyl group with 2 to 7 carbon atoms, possibly substituted once or twice in the nitrogen by low molecular weight alcohol radicals, being able to two alcohol radicals together with the nitrogen atom also form a 5- to 7-membered heterocyclic ring, which may also contain another nitrogen or oxygen atom; and A means an oxygen or sulfur atom or the group = NR5, the group = NOR5, the group = NH-NHR5 or two hydrogen atoms, the group -N (R5) -C - (= A) may be present - also in the tautomeric form -N = C (AR5) -, and its salts, characterized in that, with the addition of acid fixing agents, a compound of the formula is condensed **(See formula)** where the symbols R1 to R5 have the meanings indicated above and W means an oxygen atom or the groups = NH or = NOH, with a compound of the general formula **(See formula)** where R4 has the meanings mentioned above, A means one oxygen or sulfur atom, or two hydrogen atoms or the group = NR5, and R7 is a hydroxy group, a halogen atom, a low molecular weight alkoxy group, a mercapto group, a low molecular weight alcohol-mercapto group, an amino group or a low molecular weight alcohol-amino group, the structural element -C (= A) R7 may as a whole also be a nitrile group, and X means an amino group or a halogen atom; working in the presence of ammonia or an ammonia derivative, in case W is O and X is Hal, and the products of the process are subsequently treated in an alkaline medium, and optionally the products obtained according to the process are acylated in positions 1, 2 and/or 3 by acids or derivatives of aliphatic acids with 2 to 6 carbon atoms. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1060471A AT333284B (en) | 1971-12-09 | 1971-12-09 | PROCESS FOR THE PREPARATION OF NEW 6-AZA-3H-1,4-BENZODIAZEPINES, THEIR OPTICAL ISOMERS AND THEIR SALTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES409089A1 true ES409089A1 (en) | 1975-10-16 |
Family
ID=3623479
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES409090A Expired ES409090A1 (en) | 1971-12-09 | 1972-11-29 | Benzodizepines |
| ES409089A Expired ES409089A1 (en) | 1971-12-09 | 1972-11-29 | Benzodizepines |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES409090A Expired ES409090A1 (en) | 1971-12-09 | 1972-11-29 | Benzodizepines |
Country Status (26)
| Country | Link |
|---|---|
| JP (4) | JPS569509B2 (en) |
| AR (3) | AR201201A1 (en) |
| AT (4) | AT332877B (en) |
| AU (1) | AU473253B2 (en) |
| BE (1) | BE792541A (en) |
| CH (4) | CH594665A5 (en) |
| CS (1) | CS212736B2 (en) |
| DD (1) | DD105448A5 (en) |
| DE (1) | DE2259471C2 (en) |
| DK (1) | DK138425B (en) |
| EG (1) | EG10918A (en) |
| ES (2) | ES409090A1 (en) |
| FI (1) | FI54710C (en) |
| FR (1) | FR2162482B1 (en) |
| GB (1) | GB1400755A (en) |
| HU (1) | HU169468B (en) |
| IL (1) | IL41034A (en) |
| IT (1) | IT1035053B (en) |
| NL (1) | NL171986C (en) |
| NO (1) | NO137094C (en) |
| PL (3) | PL91828B1 (en) |
| RO (4) | RO67345A (en) |
| SE (1) | SE404803B (en) |
| SU (4) | SU468423A3 (en) |
| YU (2) | YU305972A (en) |
| ZA (1) | ZA728497B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2364636C2 (en) * | 1973-12-24 | 1982-11-04 | Degussa Ag, 6000 Frankfurt | Process for the preparation of 2-benzoyl-6-chloro-3-nitro-pyridines |
| ATE7295T1 (en) * | 1980-01-16 | 1984-05-15 | Lacer, S.A. | 2-HALO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS. |
| JPS60132610A (en) * | 1983-12-20 | 1985-07-15 | Japan Organo Co Ltd | Sludge dehydrating apparatus |
| JPS6219221A (en) * | 1985-07-16 | 1987-01-28 | Chiyoda Chem Eng & Constr Co Ltd | Filtration method and apparatus for removing fine grain incorporated in raw liquid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
| US3523939A (en) * | 1967-07-03 | 1970-08-11 | Hoffmann La Roche | 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation |
-
1971
- 1971-12-09 AT AT902174A patent/AT332877B/en active
- 1971-12-09 AT AT902274A patent/AT332878B/en active
- 1971-12-09 AT AT1060471A patent/AT333284B/en not_active IP Right Cessation
-
1972
- 1972-11-29 ES ES409090A patent/ES409090A1/en not_active Expired
- 1972-11-29 ES ES409089A patent/ES409089A1/en not_active Expired
- 1972-11-30 ZA ZA728497A patent/ZA728497B/en unknown
- 1972-11-30 FI FI3390/72A patent/FI54710C/en active
- 1972-12-05 SE SE7215858A patent/SE404803B/en unknown
- 1972-12-05 DE DE2259471A patent/DE2259471C2/en not_active Expired
- 1972-12-06 EG EG502/72A patent/EG10918A/en active
- 1972-12-06 FR FR7243359A patent/FR2162482B1/fr not_active Expired
- 1972-12-06 HU HUDE799A patent/HU169468B/hu unknown
- 1972-12-07 IT IT7254583Q patent/IT1035053B/en active
- 1972-12-07 RO RO7281197A patent/RO67345A/en unknown
- 1972-12-07 RO RO7281195A patent/RO65264A/en unknown
- 1972-12-07 PL PL1972175582A patent/PL91828B1/en unknown
- 1972-12-07 PL PL1972159365A patent/PL89682B1/en unknown
- 1972-12-07 NL NLAANVRAGE7216621,A patent/NL171986C/en not_active IP Right Cessation
- 1972-12-07 PL PL1972175581A patent/PL91876B1/en unknown
- 1972-12-07 RO RO7200073075A patent/RO62312A/en unknown
- 1972-12-07 RO RO7281196A patent/RO65263A/en unknown
- 1972-12-08 DK DK615172AA patent/DK138425B/en not_active IP Right Cessation
- 1972-12-08 NO NO4536/72A patent/NO137094C/en unknown
- 1972-12-08 CS CS728424A patent/CS212736B2/en unknown
- 1972-12-08 IL IL41034A patent/IL41034A/en unknown
- 1972-12-08 YU YU03059/72A patent/YU305972A/en unknown
- 1972-12-08 GB GB5688372A patent/GB1400755A/en not_active Expired
- 1972-12-08 BE BE792541A patent/BE792541A/en not_active IP Right Cessation
- 1972-12-08 SU SU1855103A patent/SU468423A3/en active
- 1972-12-09 JP JP12387872A patent/JPS569509B2/ja not_active Expired
- 1972-12-11 AU AU49931/72A patent/AU473253B2/en not_active Expired
- 1972-12-11 CH CH1794972A patent/CH594665A5/xx not_active IP Right Cessation
- 1972-12-11 DD DD167428A patent/DD105448A5/xx unknown
- 1972-12-11 CH CH1506576A patent/CH605946A5/xx not_active IP Right Cessation
- 1972-12-11 CH CH1526076A patent/CH603645A5/xx not_active IP Right Cessation
- 1972-12-11 CH CH1506676A patent/CH603644A5/xx not_active IP Right Cessation
-
1973
- 1973-09-10 AR AR250008A patent/AR201201A1/en active
-
1974
- 1974-03-20 AR AR252867A patent/AR200309A1/en active
- 1974-07-08 SU SU7402042686A patent/SU564809A3/en active
- 1974-07-08 SU SU742041603A patent/SU674675A3/en active
- 1974-10-15 SU SU7402067128A patent/SU574156A3/en active
- 1974-10-31 AR AR256352A patent/AR203311A1/en active
- 1974-11-11 AT AT902074A patent/AT338798B/en not_active IP Right Cessation
-
1980
- 1980-04-15 JP JP5022180A patent/JPS5625180A/en active Granted
- 1980-04-15 JP JP5022280A patent/JPS55147282A/en active Granted
- 1980-04-15 JP JP5022380A patent/JPS5625181A/en active Granted
-
1981
- 1981-05-07 YU YU01168/81A patent/YU116881A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19880204 |