DK138425B - Analogous process for the preparation of 6-aza-3H-1,4-benzodiazepines or 6-aza-1,2-dihydro-3H-1,4-benzodiazepines or salts thereof. - Google Patents

Analogous process for the preparation of 6-aza-3H-1,4-benzodiazepines or 6-aza-1,2-dihydro-3H-1,4-benzodiazepines or salts thereof.

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Publication number
DK138425B
DK138425B DK615172AA DK615172A DK138425B DK 138425 B DK138425 B DK 138425B DK 615172A A DK615172A A DK 615172AA DK 615172 A DK615172 A DK 615172A DK 138425 B DK138425 B DK 138425B
Authority
DK
Denmark
Prior art keywords
benzodiazepines
aza
dihydro
salts
preparation
Prior art date
Application number
DK615172AA
Other languages
Danish (da)
Other versions
DK138425C (en
Inventor
Walter Von Bebenburg
Heribert Offermanns
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Priority to DK319873A priority Critical patent/DK140144B/en
Publication of DK138425B publication Critical patent/DK138425B/en
Application granted granted Critical
Publication of DK138425C publication Critical patent/DK138425C/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DK615172AA 1971-12-09 1972-12-08 Analogous process for the preparation of 6-aza-3H-1,4-benzodiazepines or 6-aza-1,2-dihydro-3H-1,4-benzodiazepines or salts thereof. DK138425B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK319873A DK140144B (en) 1972-12-08 1973-06-08 Analogous process for the preparation of s-triazolo- (4,3-a) -pyrido- (2,3-f) - (1,4) -benzodiazepines or salts thereof.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1060471A AT333284B (en) 1971-12-09 1971-12-09 PROCESS FOR THE PREPARATION OF NEW 6-AZA-3H-1,4-BENZODIAZEPINES, THEIR OPTICAL ISOMERS AND THEIR SALTS

Publications (2)

Publication Number Publication Date
DK138425B true DK138425B (en) 1978-09-04
DK138425C DK138425C (en) 1979-02-12

Family

ID=3623479

Family Applications (1)

Application Number Title Priority Date Filing Date
DK615172AA DK138425B (en) 1971-12-09 1972-12-08 Analogous process for the preparation of 6-aza-3H-1,4-benzodiazepines or 6-aza-1,2-dihydro-3H-1,4-benzodiazepines or salts thereof.

Country Status (26)

Country Link
JP (4) JPS569509B2 (en)
AR (3) AR201201A1 (en)
AT (4) AT332878B (en)
AU (1) AU473253B2 (en)
BE (1) BE792541A (en)
CH (4) CH594665A5 (en)
CS (1) CS212736B2 (en)
DD (1) DD105448A5 (en)
DE (1) DE2259471C2 (en)
DK (1) DK138425B (en)
EG (1) EG10918A (en)
ES (2) ES409090A1 (en)
FI (1) FI54710C (en)
FR (1) FR2162482B1 (en)
GB (1) GB1400755A (en)
HU (1) HU169468B (en)
IL (1) IL41034A (en)
IT (1) IT1035053B (en)
NL (1) NL171986C (en)
NO (1) NO137094C (en)
PL (3) PL89682B1 (en)
RO (4) RO65264A (en)
SE (1) SE404803B (en)
SU (4) SU468423A3 (en)
YU (2) YU305972A (en)
ZA (1) ZA728497B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2364636C2 (en) * 1973-12-24 1982-11-04 Degussa Ag, 6000 Frankfurt Process for the preparation of 2-benzoyl-6-chloro-3-nitro-pyridines
DE3067662D1 (en) * 1980-01-16 1984-06-07 Lacer Sa New 2-halo-pyridines, their production and pharmaceutical compositions
JPS60132610A (en) * 1983-12-20 1985-07-15 Japan Organo Co Ltd Sludge dehydrating apparatus
JPS6219221A (en) * 1985-07-16 1987-01-28 Chiyoda Chem Eng & Constr Co Ltd Filtration method and apparatus for removing fine grain incorporated in raw liquid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314941A (en) * 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
US3523939A (en) * 1967-07-03 1970-08-11 Hoffmann La Roche 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation

Also Published As

Publication number Publication date
ES409089A1 (en) 1975-10-16
ATA902174A (en) 1976-02-15
JPS4864096A (en) 1973-09-05
RO65263B (en) 1983-06-30
CH594665A5 (en) 1978-01-13
RO67345A (en) 1980-07-15
DE2259471A1 (en) 1973-06-14
SE404803B (en) 1978-10-30
NO137094B (en) 1977-09-19
JPS5625181A (en) 1981-03-10
PL91876B1 (en) 1977-03-31
PL89682B1 (en) 1976-12-31
HU169468B (en) 1976-11-28
FR2162482A1 (en) 1973-07-20
RO65263A (en) 1983-07-07
CH605946A5 (en) 1978-10-13
DD105448A5 (en) 1974-04-20
FI54710C (en) 1979-02-12
CH603645A5 (en) 1978-08-31
JPS5744678B2 (en) 1982-09-22
NL171986C (en) 1983-06-16
SU674675A3 (en) 1979-07-15
JPS5742639B2 (en) 1982-09-09
SU564809A3 (en) 1977-07-05
JPS5625180A (en) 1981-03-10
AT338798B (en) 1977-09-12
ATA902274A (en) 1976-02-15
YU305972A (en) 1982-02-28
NL171986B (en) 1983-01-17
AU473253B2 (en) 1976-06-17
FI54710B (en) 1978-10-31
AU4993172A (en) 1974-06-13
ATA1060471A (en) 1976-03-15
AR203311A1 (en) 1975-08-29
NL7216621A (en) 1973-06-13
EG10918A (en) 1981-12-31
PL91828B1 (en) 1977-03-31
JPS55147282A (en) 1980-11-17
CH603644A5 (en) 1978-08-31
IL41034A (en) 1976-10-31
YU116881A (en) 1984-02-29
SU468423A3 (en) 1975-04-25
SU574156A3 (en) 1977-09-25
AT332877B (en) 1976-10-25
ZA728497B (en) 1973-09-26
JPS5742638B2 (en) 1982-09-09
IT1035053B (en) 1979-10-20
CS212736B2 (en) 1982-03-26
IL41034A0 (en) 1973-02-28
RO62312A (en) 1977-12-15
NO137094C (en) 1977-12-28
ES409090A1 (en) 1975-10-16
DK138425C (en) 1979-02-12
AR200309A1 (en) 1974-10-31
AT332878B (en) 1976-10-25
BE792541A (en) 1973-06-08
ATA902074A (en) 1977-01-15
AR201201A1 (en) 1975-02-21
FR2162482B1 (en) 1976-03-05
RO65264A (en) 1979-08-15
JPS569509B2 (en) 1981-03-02
DE2259471C2 (en) 1982-08-19
GB1400755A (en) 1975-07-23
AT333284B (en) 1976-11-10

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