ES406374A1 - 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents - Google Patents
1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agentsInfo
- Publication number
- ES406374A1 ES406374A1 ES406374A ES406374A ES406374A1 ES 406374 A1 ES406374 A1 ES 406374A1 ES 406374 A ES406374 A ES 406374A ES 406374 A ES406374 A ES 406374A ES 406374 A1 ES406374 A1 ES 406374A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- cyclic
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Procedure for obtaining 1- (3-trifluor-methyl-phenyl) -4- (cyclic-amido-alkyl) -piperazines, of formula: **(See formula)** where R represents a suocinimido, glutarimido, 2,4-dioxo-1 (or 3) -imidazolidinyl or 2,4-dioxo-1 (or 3) -hexahydropyrimidinyl group, the last two groups being substituted on the imido nitrogen atom with a methyl group or ethyl, X1 represents a hydrogen, fluorine, chlorine or bromine atom or a nitro group and n is 2 or 3, characterized in that a compound of formula: **(See formula)** (where X has the definition given above and Y is either a hydrogen atom or a W-aminoalkyl group of the formula - (CH2) nNH2, where n is 2 or 3) a compound of the formula Z- (CH2) nR, where Z is a halogen atom or a tosyloxy group, n is 2 or 3 and R has the definition given above, or succinic or glutaric anhydride, respectively, and a compound of the formula is recovered IA as a product. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4132271 | 1971-09-04 | ||
GB2053672A GB1368256A (en) | 1971-09-04 | 1972-05-03 | 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES406374A1 true ES406374A1 (en) | 1975-07-16 |
Family
ID=26254732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES406374A Expired ES406374A1 (en) | 1971-09-04 | 1972-09-04 | 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS4885584A (en) |
AR (1) | AR200387A1 (en) |
AT (2) | AT321307B (en) |
AU (1) | AU4594072A (en) |
BE (1) | BE788280A (en) |
CH (2) | CH551430A (en) |
DE (1) | DE2242382A1 (en) |
ES (1) | ES406374A1 (en) |
FR (1) | FR2154449A1 (en) |
GB (1) | GB1368256A (en) |
IE (1) | IE37697B1 (en) |
NL (1) | NL7211694A (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2263211A1 (en) * | 1972-12-23 | 1974-07-04 | Boehringer Sohn Ingelheim | NEW ARYLPIPERAZINE AND PROCESS FOR THEIR PRODUCTION |
DE2727469A1 (en) * | 1977-06-18 | 1978-12-21 | Hoechst Ag | NEW HEXAHYDROPYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
AU532411B2 (en) * | 1979-03-01 | 1983-09-29 | Duphar International Research B.V. | Phenyl piperazine derivatives |
NL8005133A (en) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | PHENYLPIPERAZINE DERIVATIVES WITH ANTIAGRESSIVE ACTION. |
NL8005131A (en) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | PHENYLPIPERAZINE DERIVATIVES WITH ANALGETIC ACTION. |
US4452798A (en) * | 1982-06-22 | 1984-06-05 | Warner-Lambert Company | 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents |
JPS5976059A (en) * | 1982-10-21 | 1984-04-28 | Sumitomo Chem Co Ltd | Cyclic imide derivative and its acid addition salt |
US6083950A (en) * | 1997-11-13 | 2000-07-04 | Ranbaxy Laboratories Limited | 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers |
CA2338317A1 (en) * | 1998-07-21 | 2000-02-03 | Ranbaxy Laboratories Limited | Arylpiperazine derivatives useful as uroselective alpha1-adrenoceptor blockers |
AU1979799A (en) * | 1998-07-21 | 2000-02-14 | Ranbaxy Laboratories Limited | Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers |
US20050228180A1 (en) * | 2002-04-08 | 2005-10-13 | Mohammad Salman | Alpha, omega-dicarboximide derivatives as useful uro-selective a1a adrenoceptor blockers |
-
0
- BE BE788280D patent/BE788280A/en unknown
-
1972
- 1972-05-03 GB GB2053672A patent/GB1368256A/en not_active Expired
- 1972-08-24 AU AU45940/72A patent/AU4594072A/en not_active Expired
- 1972-08-28 NL NL7211694A patent/NL7211694A/xx unknown
- 1972-08-29 DE DE19722242382 patent/DE2242382A1/en active Pending
- 1972-08-29 IE IE117372A patent/IE37697B1/en unknown
- 1972-09-01 CH CH356874A patent/CH551430A/en not_active IP Right Cessation
- 1972-09-01 CH CH1293572A patent/CH554899A/en not_active IP Right Cessation
- 1972-09-01 AT AT752072A patent/AT321307B/en not_active IP Right Cessation
- 1972-09-01 AT AT1089573A patent/AT320655B/en not_active IP Right Cessation
- 1972-09-01 FR FR7231080A patent/FR2154449A1/fr not_active Withdrawn
- 1972-09-01 AR AR24388272A patent/AR200387A1/en active
- 1972-09-04 ES ES406374A patent/ES406374A1/en not_active Expired
- 1972-09-04 JP JP8802072A patent/JPS4885584A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS4885584A (en) | 1973-11-13 |
AU4594072A (en) | 1974-02-28 |
CH554899A (en) | 1974-10-15 |
IE37697L (en) | 1973-03-04 |
AT321307B (en) | 1975-03-25 |
NL7211694A (en) | 1973-03-06 |
AR200387A1 (en) | 1974-11-08 |
FR2154449A1 (en) | 1973-05-11 |
BE788280A (en) | 1973-02-28 |
GB1368256A (en) | 1974-09-25 |
IE37697B1 (en) | 1977-09-28 |
CH551430A (en) | 1974-07-15 |
DE2242382A1 (en) | 1973-03-15 |
AT320655B (en) | 1975-02-25 |
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