ES406374A1 - 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents - Google Patents

1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents

Info

Publication number
ES406374A1
ES406374A1 ES406374A ES406374A ES406374A1 ES 406374 A1 ES406374 A1 ES 406374A1 ES 406374 A ES406374 A ES 406374A ES 406374 A ES406374 A ES 406374A ES 406374 A1 ES406374 A1 ES 406374A1
Authority
ES
Spain
Prior art keywords
formula
group
cyclic
phenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406374A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES406374A1 publication Critical patent/ES406374A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedure for obtaining 1- (3-trifluor-methyl-phenyl) -4- (cyclic-amido-alkyl) -piperazines, of formula: **(See formula)** where R represents a suocinimido, glutarimido, 2,4-dioxo-1 (or 3) -imidazolidinyl or 2,4-dioxo-1 (or 3) -hexahydropyrimidinyl group, the last two groups being substituted on the imido nitrogen atom with a methyl group or ethyl, X1 represents a hydrogen, fluorine, chlorine or bromine atom or a nitro group and n is 2 or 3, characterized in that a compound of formula: **(See formula)** (where X has the definition given above and Y is either a hydrogen atom or a W-aminoalkyl group of the formula - (CH2) nNH2, where n is 2 or 3) a compound of the formula Z- (CH2) nR, where Z is a halogen atom or a tosyloxy group, n is 2 or 3 and R has the definition given above, or succinic or glutaric anhydride, respectively, and a compound of the formula is recovered IA as a product. (Machine-translation by Google Translate, not legally binding)
ES406374A 1971-09-04 1972-09-04 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents Expired ES406374A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4132271 1971-09-04
GB2053672A GB1368256A (en) 1971-09-04 1972-05-03 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents

Publications (1)

Publication Number Publication Date
ES406374A1 true ES406374A1 (en) 1975-07-16

Family

ID=26254732

Family Applications (1)

Application Number Title Priority Date Filing Date
ES406374A Expired ES406374A1 (en) 1971-09-04 1972-09-04 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents

Country Status (12)

Country Link
JP (1) JPS4885584A (en)
AR (1) AR200387A1 (en)
AT (2) AT321307B (en)
AU (1) AU4594072A (en)
BE (1) BE788280A (en)
CH (2) CH551430A (en)
DE (1) DE2242382A1 (en)
ES (1) ES406374A1 (en)
FR (1) FR2154449A1 (en)
GB (1) GB1368256A (en)
IE (1) IE37697B1 (en)
NL (1) NL7211694A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2263211A1 (en) * 1972-12-23 1974-07-04 Boehringer Sohn Ingelheim NEW ARYLPIPERAZINE AND PROCESS FOR THEIR PRODUCTION
DE2727469A1 (en) * 1977-06-18 1978-12-21 Hoechst Ag NEW HEXAHYDROPYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
AU532411B2 (en) * 1979-03-01 1983-09-29 Duphar International Research B.V. Phenyl piperazine derivatives
NL8005133A (en) * 1980-09-12 1982-04-01 Duphar Int Res PHENYLPIPERAZINE DERIVATIVES WITH ANTIAGRESSIVE ACTION.
NL8005131A (en) * 1980-09-12 1982-04-01 Duphar Int Res PHENYLPIPERAZINE DERIVATIVES WITH ANALGETIC ACTION.
US4452798A (en) * 1982-06-22 1984-06-05 Warner-Lambert Company 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents
JPS5976059A (en) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd Cyclic imide derivative and its acid addition salt
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
CA2338317A1 (en) * 1998-07-21 2000-02-03 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as uroselective alpha1-adrenoceptor blockers
AU1979799A (en) * 1998-07-21 2000-02-14 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers
US20050228180A1 (en) * 2002-04-08 2005-10-13 Mohammad Salman Alpha, omega-dicarboximide derivatives as useful uro-selective a1a adrenoceptor blockers

Also Published As

Publication number Publication date
JPS4885584A (en) 1973-11-13
AU4594072A (en) 1974-02-28
CH554899A (en) 1974-10-15
IE37697L (en) 1973-03-04
AT321307B (en) 1975-03-25
NL7211694A (en) 1973-03-06
AR200387A1 (en) 1974-11-08
FR2154449A1 (en) 1973-05-11
BE788280A (en) 1973-02-28
GB1368256A (en) 1974-09-25
IE37697B1 (en) 1977-09-28
CH551430A (en) 1974-07-15
DE2242382A1 (en) 1973-03-15
AT320655B (en) 1975-02-25

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