ES406130A1 - Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES406130A1
ES406130A1 ES406130A ES406130A ES406130A1 ES 406130 A1 ES406130 A1 ES 406130A1 ES 406130 A ES406130 A ES 406130A ES 406130 A ES406130 A ES 406130A ES 406130 A1 ES406130 A1 ES 406130A1
Authority
ES
Spain
Prior art keywords
general formula
formula
carbon atoms
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406130A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES406130A1 publication Critical patent/ES406130A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedure for the preparation of new 4- (4-biphenyl) -butyric acids and their esters of the general formula I **(See formula)** wherein R1 signifies a hydrogen or halogen atom; R2 means a halogen atom, the nitro group, an amino group optionally substituted by an acyl radical with 1 to 4 carbon atoms or an alcohol radical with 1 to 3 carbon atoms; and R3 means a hydrogen atom or an alcohol radical with 1 to 3 carbon atoms and, if R3 represents a hydrogen atom, its physiologically compatible salts with organic or inorganic bases, characterized in that it is reacted in the presence of Lewis n Biphenyl Acids of the general formula II **(See formula)** in which R1 and R2 have the meanings indicated above, with a 4-halogen-butyric acid derivative of the general formula III **(See formula)** in which R3 has the meanings indicated above and Hal means a halogen atom; and, in the event that a compound of the general formula I is obtained, in which R3 represents an alcoholic radical, this is hydrolyzed, if desired, subsequently in an alkaline or acidic medium and/or, in the event that a compound of the formula is obtained General I, in which R3 represents a hydrogen atom, is converted, if desired, into a physiologically compatible salt with an organic or inorganic base or an ester of the general formula I. (Machine-translation by Google Translate, not legally binding)
ES406130A 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding) Expired ES406130A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712112840 DE2112840A1 (en) 1971-03-17 1971-03-17 New 4- (4-biphenylyl) butyric acids, their salts and esters

Publications (1)

Publication Number Publication Date
ES406130A1 true ES406130A1 (en) 1975-07-16

Family

ID=5801828

Family Applications (11)

Application Number Title Priority Date Filing Date
ES400792A Expired ES400792A1 (en) 1971-03-17 1972-03-15 Procedure for the preparation of new acids 4- (4-bifenilil) -butiricos and their steres. (Machine-translation by Google Translate, not legally binding)
ES406132A Expired ES406132A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406127A Expired ES406127A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406129A Expired ES406129A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406124A Expired ES406124A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406131A Expired ES406131A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406123A Expired ES406123A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406128A Expired ES406128A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406125A Expired ES406125A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406126A Expired ES406126A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406130A Expired ES406130A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (10)

Application Number Title Priority Date Filing Date
ES400792A Expired ES400792A1 (en) 1971-03-17 1972-03-15 Procedure for the preparation of new acids 4- (4-bifenilil) -butiricos and their steres. (Machine-translation by Google Translate, not legally binding)
ES406132A Expired ES406132A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406127A Expired ES406127A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406129A Expired ES406129A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406124A Expired ES406124A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406131A Expired ES406131A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406123A Expired ES406123A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406128A Expired ES406128A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406125A Expired ES406125A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of acids 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES406126A Expired ES406126A1 (en) 1971-03-17 1972-08-26 Procedure for the preparation of 4- (4-bifenilil) -butirrics and their steres. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
AT (2) AT321287B (en)
CH (13) CH566958A5 (en)
DE (1) DE2112840A1 (en)
DK (1) DK132942C (en)
ES (11) ES400792A1 (en)
FR (1) FR2282866A1 (en)
SE (1) SE393101B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677360B2 (en) * 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en) * 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
AR044152A1 (en) 2003-05-09 2005-08-24 Bayer Corp RENTAL DERIVATIVES, METHOD OF PREPARATION AND USE FOR THE TREATMENT OF OBESITY

Also Published As

Publication number Publication date
DE2112840A1 (en) 1972-10-05
AT310725B (en) 1973-10-10
ES406128A1 (en) 1975-07-16
FR2282866A1 (en) 1976-03-26
CH566959A5 (en) 1975-09-30
AT321287B (en) 1975-03-25
CH574386A5 (en) 1976-04-15
CH573890A5 (en) 1976-03-31
ES406125A1 (en) 1975-08-01
DK132942C (en) 1976-08-02
CH580050A5 (en) 1976-09-30
ES406123A1 (en) 1975-08-01
CH566960A5 (en) 1975-09-30
CH574385A5 (en) 1976-04-15
ES400792A1 (en) 1975-01-16
ES406126A1 (en) 1975-07-16
ES406132A1 (en) 1975-07-16
ES406131A1 (en) 1975-08-01
DK132942B (en) 1976-03-01
CH573895A5 (en) 1976-03-31
SE393101B (en) 1977-05-02
CH566956A5 (en) 1975-09-30
CH573893A5 (en) 1976-03-31
CH573889A5 (en) 1976-03-31
ES406127A1 (en) 1975-07-16
CH566957A5 (en) 1975-09-30
CH566958A5 (en) 1975-09-30
ES406129A1 (en) 1975-07-16
ES406124A1 (en) 1975-08-01
CH573894A5 (en) 1976-03-31
FR2282866B1 (en) 1978-07-21

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