ES401235A1 - Aminopropanol derivative - Google Patents

Aminopropanol derivative

Info

Publication number
ES401235A1
ES401235A1 ES401235A ES401235A ES401235A1 ES 401235 A1 ES401235 A1 ES 401235A1 ES 401235 A ES401235 A ES 401235A ES 401235 A ES401235 A ES 401235A ES 401235 A1 ES401235 A1 ES 401235A1
Authority
ES
Spain
Prior art keywords
dichlorophenoxy
tert
propanol
reacted
butylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES401235A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES401235A1 publication Critical patent/ES401235A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms

Abstract

Procedure for the preparation of 1- (2,5-dichlorophenoxy) -3-tert-butylamino-2-propanol and its salts, particularly for the preparation of 1- (2,5-dichlorophenoxy) -3-tert-butylamino-2- racemic and optically active propanol and its salts, characterized in that a/1- (2,5-Dichlorophenoxy) -2,3-epoxypropane is reacted with tert-butylamine, or b/1- (2,5-diolorophenoxy) -3-chloro-2-propanol is reacted with tert-butylamine, or c/sodium 2,5-dichlorophenolate is reacted with 1-halo-3-tert-butylamino-2-propanol, or d/2,5-dichlorophenol is reacted with 1,2-epoxy-3-tert-butylaminopropane, or e/a diastereomeric salt pair of (±) - 1- (2,5-dichlorophenoxy) -3-tert-butylamino-2-propanol formed with (-) or (+) - dibenzoyltartaric acid is subjected to fractional crystallization in a low molecular weight alcohol at a temperature above 40ºC, or f/2,5-dichlorophenol is reacted with epichlorohydrin, 1- (2,5-dichlorophenoxy) -2,3-epoxypropane or 1- (2,5-dichlorophenoxy) -3-chloro-2-propanol is reacted obtained with ammonia, the 1- (2,5-dichlorophenoxy) -3-amino-2-propanol obtained in its diastereomeric salt pair is converted with (-) or (+) - dibenzoyltartramide, the obtained salt pair is subjected to fractional crystallization and (-) and (+) - 1- (2,5-dichlorophenoxy) -3-amino-2-propanol is alkylated on the nitrogen atom with tert-butyl halide, and, if desired, the free base obtained by any of the processes obtained is converted to its acid addition salt, or the salt is converted to the free base. (Machine-translation by Google Translate, not legally binding)
ES401235A 1971-03-17 1972-03-11 Aminopropanol derivative Expired ES401235A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUGO001156 1971-03-17

Publications (1)

Publication Number Publication Date
ES401235A1 true ES401235A1 (en) 1975-02-16

Family

ID=10996691

Family Applications (1)

Application Number Title Priority Date Filing Date
ES401235A Expired ES401235A1 (en) 1971-03-17 1972-03-11 Aminopropanol derivative

Country Status (19)

Country Link
JP (1) JPS5310581B1 (en)
AT (1) AT316515B (en)
AU (1) AU461159B2 (en)
BE (1) BE780719A (en)
CA (1) CA1002537A (en)
CH (1) CH569692A5 (en)
CS (1) CS163270B2 (en)
DK (1) DK133872B (en)
ES (1) ES401235A1 (en)
FI (1) FI55025C (en)
FR (1) FR2130284B1 (en)
GB (1) GB1337921A (en)
IL (1) IL38870A (en)
NL (1) NL170626C (en)
NO (1) NO134836C (en)
PL (1) PL88985B1 (en)
SE (1) SE384021B (en)
SU (1) SU496721A3 (en)
YU (1) YU35435B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU172137B (en) 1976-03-02 1978-06-28 Gyogyszerkutato Intezet Process for preparing substituted derivatives of the phenoxy-propanolamine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1236523C2 (en) * 1962-02-15 1975-06-12 Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim PROCESS FOR THE PRODUCTION OF BASIC PHENYLAETHERS AND THEIR SALTS

Also Published As

Publication number Publication date
NL170626B (en) 1982-07-01
PL88985B1 (en) 1976-10-30
DK133872C (en) 1976-12-27
IL38870A0 (en) 1972-05-30
AU461159B2 (en) 1975-04-29
YU63972A (en) 1980-06-30
NL170626C (en) 1982-12-01
YU35435B (en) 1981-02-28
FI55025B (en) 1979-01-31
FR2130284A1 (en) 1972-11-03
AT316515B (en) 1974-07-10
SU496721A3 (en) 1975-12-25
CA1002537A (en) 1976-12-28
DE2213044B2 (en) 1977-05-26
FI55025C (en) 1979-05-10
NO134836C (en) 1976-12-21
BE780719A (en) 1972-07-03
NO134836B (en) 1976-09-13
SE384021B (en) 1976-04-12
DE2213044A1 (en) 1972-09-28
CH569692A5 (en) 1975-11-28
AU3965972A (en) 1973-09-13
GB1337921A (en) 1973-11-21
JPS5310581B1 (en) 1978-04-14
CS163270B2 (en) 1975-08-29
NL7203323A (en) 1972-09-19
DK133872B (en) 1976-08-02
FR2130284B1 (en) 1975-10-10
IL38870A (en) 1975-08-31

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