ES398162A1 - Process for the preparation of benzodiazepine derivatives - Google Patents

Abstract

A PROCEDURE FOR THE PREPARATION OF A BENZODIACEPINE DERIVATIVE, which has the formula ** (See formula) ** wherein R1, R2, and R5 may be the same or different, and each represents a hydrogen atom, a low alkyl group, a low alkoxy group, a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a hydroxyl group, a low alkylthio group, a carboxyl group, an alkoxycarbonyl group, an acyl group, a carbamoyl group, an N-mono-alkyl substituted carbamoyl group, a N, N-di-substituted alkyl carbamoyl group, an amino group, an N-mono-substituted alkyl amino group, an N, N-di-alkyl-substituted amino group, an acylamino group, an acyloxy group, an alkylsulfonyl group or an alkylsulfinyl group, R3 represents a hydrogen atom, a low alkyl group, a cycloalkyl group, an aralkyl group, an aryl group, a phenacyl group, a halogenated alkyl group, a hydroxyalkyl group or an N, N-di-alkylaminoalkyl group and R4 represents a hydrogen atom or an alkyl ba group jo comprising the reaction of a compound having the formula ** (See formula) ** where R1, R2, R3, R4 and R5 are the same as above, A represents a polymethylan group which can be substituted by a low alkyl group and X represents an acid radical with a carboxylic acid or the reactive derivative thereof in the presence or absence of a catalytic. (Machine-translation by Google Translate, not legally binding)