ES394683A1 - A method for preparing an appropriate product for employment in the treatment of trematodos hepaticos de mamiferos (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A method of preparing a product suitable for use in the treatment of mammalian liver trematode infections, comprising a compound of formula (I) **(See formula)** wherein R and R1 are the same or different, and each is hydrogen, an optionally substituted saturated aliphatic hydrocarbon group having 1 to 7 carbon atoms, or an unsaturated aliphatic hydrocarbon group having 2 to 4 carbon atoms. carbon, R2 and R3 are the same or different and each is hydrogen or a lower alcohol group having 1 to 4 carbon atoms, and A is -CH2-, - (CH2) 2-, -CH2-0-CH2- or the group **(See formula)** where X and X1 y are the same or different and each is hydrogen or an alcohol group having 1 to 3 carbon atoms, or, when at the hands one of R and r1 is a saturated aliphatic hydrocarbon group having 1 to 7 carbon atoms and is substituted by an amino group or by an N-alkylamino or N, N-dialkoxylamino group in which the "alcoholyl" has 1 to 4 carbon atoms, an acid addition salt thereof, in association with an inert excipient therefor, characterized in that: a) the compound of formula (I) is prepared by reacting an ether of formula (IV) in a liquid medium **(See formula)** wherein X is a reactive nucleophilic atom or group, A is as indicated above, B is R or R1, and E is R2 or R3, as indicated above, with an alkali metal salt of a p-hydroxyacyanilide of formula (III) **(See formula)** where "Alo" is an alkali metal and B and E are as defined above; or b) the compound of formula (I) is prepared by acylation of an amine of formula **(See formula)** wherein A, R2 and R3 are as defined above and one of R4 is hydrogen and the other is also hydrogen or is an M.CO- group, where M is one of R and R1, as indicated above, and, when at least one of R and R1 is a saturated aliphatic hydrocarbon group having 1 to 7 carbon atoms, it is substituted by an amino group or by an N-alcoholylamino or N, N-dialkoylamino group where the "alcoholic" has from 1 to 4 carbon atoms, the product is optionally converted by known means into the base, an acid addition salt thereof or the salt of another acid, as appropriate, and the compound of formula (I) is mixed or one of its acid addition salts, as defined above, with an inert carrier therefor. (Machine-translation by Google Translate, not legally binding)