ES393101A1 - Thieno-diazepin derivatives - Google Patents

Thieno-diazepin derivatives

Info

Publication number
ES393101A1
ES393101A1 ES393101A ES393101A ES393101A1 ES 393101 A1 ES393101 A1 ES 393101A1 ES 393101 A ES393101 A ES 393101A ES 393101 A ES393101 A ES 393101A ES 393101 A1 ES393101 A1 ES 393101A1
Authority
ES
Spain
Prior art keywords
general formula
see formula
formula
thieno
see
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES393101A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Priority to ES393101A priority Critical patent/ES393101A1/en
Priority to HUMA2378A priority patent/HU167935B/hu
Priority to SE7208936A priority patent/SE397350B/en
Priority to GB3175272A priority patent/GB1409554A/en
Priority to FR7224523A priority patent/FR2145503B1/fr
Priority to ZA724697A priority patent/ZA724697B/en
Priority to CH1017872A priority patent/CH566338A5/xx
Priority to AU44329/72A priority patent/AU457374B2/en
Priority to AR242961A priority patent/AR196408A1/en
Priority to DE2233457A priority patent/DE2233457A1/en
Priority to NL7209461A priority patent/NL7209461A/xx
Priority to BE785998A priority patent/BE785998A/en
Priority to SU1809322A priority patent/SU526289A3/en
Priority to RO71562A priority patent/RO61516A/ro
Priority to AT591572A priority patent/AT331799B/en
Publication of ES393101A1 publication Critical patent/ES393101A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of thieno-diazepine derivatives of the general formula: **(See formula)** wherein R1 and R2 each represent a hydrogen atom or a branched or normal alcohol radical with 1-6 carbon atoms containing or not substituents in the form of aromatic radicals, and together a polymethylene chain of three to six links, R3 a phenyl group, which in some cases has substituents such as chlorine, nitro, or trochloromethyl in the orthometa or para positions, and R4 a hydrogen atom or a normal or branched alcohol radical with 1-3 atoms of carbon, or an alkoxycarbonyl radical, characterized by thiophene derivatives of the general formula **(See formula)** in which R1, R2 and R3 have the same significance as before, they are reacted, in a first step, with others of general formula **(See formula)** in which R4 has the indicated significance and X represents an atom of chlorine, bromine, iodine, so that the products obtained, of general formula **(See formula)** in a second stage, they undergo a reaction with aqueous hydrazine in an alcohol to transform them into others of general formula **(See formula)** which, either spontaneously or by heating in a suitable solvent, are cycled to the desired thieno-diazepine, without the need to isolate them in pure form. (Machine-translation by Google Translate, not legally binding)
ES393101A 1971-07-09 1971-07-09 Thieno-diazepin derivatives Expired ES393101A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
ES393101A ES393101A1 (en) 1971-07-09 1971-07-09 Thieno-diazepin derivatives
HUMA2378A HU167935B (en) 1971-07-09 1972-07-05
SE7208936A SE397350B (en) 1971-07-09 1972-07-06 PROCEDURE FOR THE PREPARATION OF TIENO-DIAZEPINE DERIVATIVES
GB3175272A GB1409554A (en) 1971-07-09 1972-07-06 Thieno-diazepin derivatives
FR7224523A FR2145503B1 (en) 1971-07-09 1972-07-06
ZA724697A ZA724697B (en) 1971-07-09 1972-07-07 Thieno-diazepine derivatives and method of preparation thereof
CH1017872A CH566338A5 (en) 1971-07-09 1972-07-07
AU44329/72A AU457374B2 (en) 1972-07-07 Thieno-diazepin derivatives and method of preparation thereof
AR242961A AR196408A1 (en) 1971-07-09 1972-07-07 PROCEDURE FOR THE PREPARATION OF TIENODIAZEPINE DERIVATIVES
DE2233457A DE2233457A1 (en) 1971-07-09 1972-07-07 THIENYLDIACEPINE DERIVATIVES AND THE METHOD FOR THEIR PRODUCTION
NL7209461A NL7209461A (en) 1971-07-09 1972-07-07
BE785998A BE785998A (en) 1971-07-09 1972-07-07 THIENO-DIAZEPINE DERIVATIVES AND THEIR PREPARATION PROCESS
SU1809322A SU526289A3 (en) 1971-07-09 1972-07-08 Method for preparing thienidiazepine derivatives
RO71562A RO61516A (en) 1971-07-09 1972-07-10
AT591572A AT331799B (en) 1971-07-09 1972-07-10 PROCESS FOR THE PRODUCTION OF THIENODIAZEPINE DERIVATIVES AND THEIR SALT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES393101A ES393101A1 (en) 1971-07-09 1971-07-09 Thieno-diazepin derivatives

Publications (1)

Publication Number Publication Date
ES393101A1 true ES393101A1 (en) 1974-05-16

Family

ID=8458749

Family Applications (1)

Application Number Title Priority Date Filing Date
ES393101A Expired ES393101A1 (en) 1971-07-09 1971-07-09 Thieno-diazepin derivatives

Country Status (14)

Country Link
AR (1) AR196408A1 (en)
AT (1) AT331799B (en)
BE (1) BE785998A (en)
CH (1) CH566338A5 (en)
DE (1) DE2233457A1 (en)
ES (1) ES393101A1 (en)
FR (1) FR2145503B1 (en)
GB (1) GB1409554A (en)
HU (1) HU167935B (en)
NL (1) NL7209461A (en)
RO (1) RO61516A (en)
SE (1) SE397350B (en)
SU (1) SU526289A3 (en)
ZA (1) ZA724697B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112607B2 (en) 1997-10-29 2006-09-26 King Pharmaceuticals Research & Development, Inc. Allosteric adenosine receptor modulators

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112607B2 (en) 1997-10-29 2006-09-26 King Pharmaceuticals Research & Development, Inc. Allosteric adenosine receptor modulators

Also Published As

Publication number Publication date
FR2145503A1 (en) 1973-02-23
SE397350B (en) 1977-10-31
BE785998A (en) 1972-11-03
ZA724697B (en) 1973-04-25
GB1409554A (en) 1975-10-08
NL7209461A (en) 1973-01-11
AU4432972A (en) 1974-01-10
FR2145503B1 (en) 1975-10-17
RO61516A (en) 1977-04-15
AR196408A1 (en) 1973-12-27
CH566338A5 (en) 1975-09-15
SU526289A3 (en) 1976-08-25
DE2233457A1 (en) 1973-02-22
ATA591572A (en) 1975-12-15
HU167935B (en) 1976-01-28
AT331799B (en) 1976-08-25

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