ES390111A1 - Un procedimiento para la preparacion de compuestos esteroi-des. - Google Patents
Un procedimiento para la preparacion de compuestos esteroi-des.Info
- Publication number
- ES390111A1 ES390111A1 ES390111A ES390111A ES390111A1 ES 390111 A1 ES390111 A1 ES 390111A1 ES 390111 A ES390111 A ES 390111A ES 390111 A ES390111 A ES 390111A ES 390111 A1 ES390111 A1 ES 390111A1
- Authority
- ES
- Spain
- Prior art keywords
- contacting
- see formula
- hydrogen
- product
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 150000002170 ethers Chemical class 0.000 abstract 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 abstract 2
- 229940071536 silver acetate Drugs 0.000 abstract 2
- -1 steroid compounds Chemical class 0.000 abstract 2
- GZHAIVPCIUYJBA-NWUMPJBXSA-N 2-[(8R,9S,10R,13S,14S,17S)-6,6-difluoro-17-hydroxy-10,13-dimethyl-3-oxo-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]ethyl acetate Chemical compound O=C1C=C2C(C[C@H]3[C@@H]4CC[C@](CCOC(C)=O)([C@]4(CC[C@@H]3[C@]2(CC1)C)C)O)(F)F GZHAIVPCIUYJBA-NWUMPJBXSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003021 water soluble solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3100270A | 1970-04-22 | 1970-04-22 | |
| US10566571A | 1971-01-11 | 1971-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES390111A1 true ES390111A1 (es) | 1974-06-16 |
Family
ID=26706704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES390111A Expired ES390111A1 (es) | 1970-04-22 | 1971-04-13 | Un procedimiento para la preparacion de compuestos esteroi-des. |
Country Status (12)
| Country | Link |
|---|---|
| AR (1) | AR193811A1 (enExample) |
| BE (1) | BE765554A (enExample) |
| CA (1) | CA942294A (enExample) |
| DE (1) | DE2118752A1 (enExample) |
| DK (1) | DK129791B (enExample) |
| ES (1) | ES390111A1 (enExample) |
| FI (1) | FI47093C (enExample) |
| FR (1) | FR2092069B1 (enExample) |
| GB (3) | GB1348941A (enExample) |
| IL (1) | IL36428A (enExample) |
| NL (1) | NL7105386A (enExample) |
| SE (1) | SE368824B (enExample) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1468605A (fr) * | 1959-05-11 | 1967-02-10 | Upjohn Co | Procédé de fabrication de la 6alpha-fluoro-16-méthyl-17alpha, 21-dihydroxy-4-prégnène-3, 20-dione et de ses 21 esters |
| US3546215A (en) * | 1967-10-18 | 1970-12-08 | Syntex Corp | 6-gem-difluoro steroids |
-
1971
- 1971-03-17 IL IL36428A patent/IL36428A/xx unknown
- 1971-03-18 SE SE03515/71A patent/SE368824B/xx unknown
- 1971-03-26 AR AR234707A patent/AR193811A1/es active
- 1971-04-05 CA CA109,655A patent/CA942294A/en not_active Expired
- 1971-04-07 FR FR7112310A patent/FR2092069B1/fr not_active Expired
- 1971-04-09 BE BE765554A patent/BE765554A/xx unknown
- 1971-04-13 ES ES390111A patent/ES390111A1/es not_active Expired
- 1971-04-14 FI FI711028A patent/FI47093C/fi active
- 1971-04-17 DE DE19712118752 patent/DE2118752A1/de active Pending
- 1971-04-21 NL NL7105386A patent/NL7105386A/xx unknown
- 1971-04-21 DK DK191271AA patent/DK129791B/da unknown
- 1971-04-22 GB GB1082371*[A patent/GB1348941A/en not_active Expired
- 1971-04-22 GB GB1082371*[A patent/GB1348942A/en not_active Expired
- 1971-04-22 GB GB1082371*[A patent/GB1348943A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1348941A (en) | 1974-03-27 |
| CA942294A (en) | 1974-02-19 |
| FR2092069B1 (enExample) | 1974-08-23 |
| FI47093C (fi) | 1973-09-10 |
| DK129791B (da) | 1974-11-18 |
| NL7105386A (enExample) | 1971-10-26 |
| SE368824B (enExample) | 1974-07-22 |
| IL36428A (en) | 1975-05-22 |
| FR2092069A1 (enExample) | 1972-01-21 |
| IL36428A0 (en) | 1971-05-26 |
| DE2118752A1 (de) | 1971-11-04 |
| GB1348942A (en) | 1974-03-27 |
| AR193811A1 (es) | 1973-05-31 |
| FI47093B (enExample) | 1973-05-31 |
| BE765554A (fr) | 1971-10-11 |
| GB1348943A (en) | 1974-03-27 |
| DK129791C (enExample) | 1975-04-28 |
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