CA942294A - PROCESS FOR THE PREPARATION OF 6,6-DIFLUORO-11.beta.,17.alpha.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE AND OF ITS 16-METHYL HOMOLOGS - Google Patents

PROCESS FOR THE PREPARATION OF 6,6-DIFLUORO-11.beta.,17.alpha.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE AND OF ITS 16-METHYL HOMOLOGS

Info

Publication number
CA942294A
CA942294A CA109,655A CA109655A CA942294A CA 942294 A CA942294 A CA 942294A CA 109655 A CA109655 A CA 109655A CA 942294 A CA942294 A CA 942294A
Authority
CA
Canada
Prior art keywords
trihydroxypregn
dione
difluoro
ene
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA109,655A
Other versions
CA109655S (en
Inventor
Richard M. Scribner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of CA942294A publication Critical patent/CA942294A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
CA109,655A 1970-04-22 1971-04-05 PROCESS FOR THE PREPARATION OF 6,6-DIFLUORO-11.beta.,17.alpha.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE AND OF ITS 16-METHYL HOMOLOGS Expired CA942294A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3100270A 1970-04-22 1970-04-22
US10566571A 1971-01-11 1971-01-11

Publications (1)

Publication Number Publication Date
CA942294A true CA942294A (en) 1974-02-19

Family

ID=26706704

Family Applications (1)

Application Number Title Priority Date Filing Date
CA109,655A Expired CA942294A (en) 1970-04-22 1971-04-05 PROCESS FOR THE PREPARATION OF 6,6-DIFLUORO-11.beta.,17.alpha.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE AND OF ITS 16-METHYL HOMOLOGS

Country Status (12)

Country Link
AR (1) AR193811A1 (en)
BE (1) BE765554A (en)
CA (1) CA942294A (en)
DE (1) DE2118752A1 (en)
DK (1) DK129791B (en)
ES (1) ES390111A1 (en)
FI (1) FI47093C (en)
FR (1) FR2092069B1 (en)
GB (3) GB1348942A (en)
IL (1) IL36428A (en)
NL (1) NL7105386A (en)
SE (1) SE368824B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1468605A (en) * 1959-05-11 1967-02-10 Upjohn Co Manufacturing process of 6alpha-fluoro-16-methyl-17alpha, 21-dihydroxy-4-pregnene-3, 20-dione and its 21 esters
US3546215A (en) * 1967-10-18 1970-12-08 Syntex Corp 6-gem-difluoro steroids

Also Published As

Publication number Publication date
DE2118752A1 (en) 1971-11-04
GB1348942A (en) 1974-03-27
GB1348943A (en) 1974-03-27
AR193811A1 (en) 1973-05-31
DK129791B (en) 1974-11-18
FI47093C (en) 1973-09-10
GB1348941A (en) 1974-03-27
IL36428A (en) 1975-05-22
ES390111A1 (en) 1974-06-16
DK129791C (en) 1975-04-28
FI47093B (en) 1973-05-31
SE368824B (en) 1974-07-22
FR2092069A1 (en) 1972-01-21
BE765554A (en) 1971-10-11
FR2092069B1 (en) 1974-08-23
IL36428A0 (en) 1971-05-26
NL7105386A (en) 1971-10-26

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