ES387542A1 - A procedure for the preparation of new acids 2- aroil - pirrol - 2 - carboxylic and its derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A procedure for the preparation of new 2-aroyl-pyrrole-2-carboxylic acids and their derivatives of formulas: **(See formula)** where Ar represents a member selected from the group consisting of phenyl, thienyl, 5-methylthienyl, monosubstituted phenyl and polysubstituted phenyl, each substituent for said substituted phenyls being a member selected from the group consisting of halogen, lower alkyl, trifluoromethyl, lower alkoxy, nitro, amino, cyano and methylthio; Ar1 represents a member selected from the group consisting of phenyl, monosubstituted phenyl and polysubstituted phenyl, each substituent of said substituted phenyls being a member selected from the group consisting of halogen, lower alkyl and lower alkoxy; R represents a member selected from the group consisting of hydrogen and lower alkyl; R1 represents a member selected from the group consisting of hydrogen, lower alkyl and benzyl; R2 represents a member selected from the group consisting of CN, COOH, COO- (lower alkyl), CONH2, CONH- (lower alkyl), CON- (lower alkyl) 2, CONH-OH and CONH (CH2) nN- (alkyl bottom) 2, where n is an integer from 2 to 4; R3 represents a member selected from the group consisting of COOH, COO- (lower alkyl), CONH2, CONH- (lower alkyl) and CON- (lower alkyl) 2; R4 represents lower alkyl; R5 represents lower alkyl; and R6 represents a member selected from the group consisting of hydrogen and lower alkyl; with the condition of (i) when said Ar is a member selected from the group consisting of nitrophenyl and aminophenyl, then, in formula (Ia), said R is hydrogen, R1 is lower alkyl and R2 is a member selected from the group consisting of CN, COOH and C00- (lower alkyl); and in formula (I-e), R6 is hydrogen; (ii) when said Ar is cyanophenyl, then R1 is lower alkyl and R2 is a member selected from the group consisting of COOH and COO- (lower alkyl); and (iii) when R1 is hydrogen, then R is hydrogen; whose procedure is characterized by reacting compounds of formula **(See formula)** where R, R1, R4, R5 and R6 have the meaning given above, with a compound of formula ArCO-N (R'') 2 where R'' is an organic radical and the N atom together with the two groups (R'') 5 can be cyclic, in the presence of a condensing agent, preferably in an inert solvent, to prepare compounds of formulas (Ia), (Ib), (Ic) or (Ie) where R2 or R3 are COO (Alz) and, optionally, subsequently converting these compounds to other functional derivatives by appropriate reactions. (Machine-translation by Google Translate, not legally binding)