ES387542A1 - A procedure for the preparation of new acids 2- aroil - pirrol - 2 - carboxylic and its derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of new acids 2- aroil - pirrol - 2 - carboxylic and its derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES387542A1 ES387542A1 ES387542A ES387542A ES387542A1 ES 387542 A1 ES387542 A1 ES 387542A1 ES 387542 A ES387542 A ES 387542A ES 387542 A ES387542 A ES 387542A ES 387542 A1 ES387542 A1 ES 387542A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- group
- member selected
- hydrogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
A procedure for the preparation of new 2-aroyl-pyrrole-2-carboxylic acids and their derivatives of formulas: **(See formula)** where Ar represents a member selected from the group consisting of phenyl, thienyl, 5-methylthienyl, monosubstituted phenyl and polysubstituted phenyl, each substituent for said substituted phenyls being a member selected from the group consisting of halogen, lower alkyl, trifluoromethyl, lower alkoxy, nitro, amino, cyano and methylthio; Ar1 represents a member selected from the group consisting of phenyl, monosubstituted phenyl and polysubstituted phenyl, each substituent of said substituted phenyls being a member selected from the group consisting of halogen, lower alkyl and lower alkoxy; R represents a member selected from the group consisting of hydrogen and lower alkyl; R1 represents a member selected from the group consisting of hydrogen, lower alkyl and benzyl; R2 represents a member selected from the group consisting of CN, COOH, COO- (lower alkyl), CONH2, CONH- (lower alkyl), CON- (lower alkyl) 2, CONH-OH and CONH (CH2) nN- (alkyl bottom) 2, where n is an integer from 2 to 4; R3 represents a member selected from the group consisting of COOH, COO- (lower alkyl), CONH2, CONH- (lower alkyl) and CON- (lower alkyl) 2; R4 represents lower alkyl; R5 represents lower alkyl; and R6 represents a member selected from the group consisting of hydrogen and lower alkyl; with the condition of (i) when said Ar is a member selected from the group consisting of nitrophenyl and aminophenyl, then, in formula (Ia), said R is hydrogen, R1 is lower alkyl and R2 is a member selected from the group consisting of CN, COOH and C00- (lower alkyl); and in formula (I-e), R6 is hydrogen; (ii) when said Ar is cyanophenyl, then R1 is lower alkyl and R2 is a member selected from the group consisting of COOH and COO- (lower alkyl); and (iii) when R1 is hydrogen, then R is hydrogen; whose procedure is characterized by reacting compounds of formula **(See formula)** where R, R1, R4, R5 and R6 have the meaning given above, with a compound of formula ArCO-N (R'') 2 where R'' is an organic radical and the N atom together with the two groups (R'') 5 can be cyclic, in the presence of a condensing agent, preferably in an inert solvent, to prepare compounds of formulas (Ia), (Ib), (Ic) or (Ie) where R2 or R3 are COO (Alz) and, optionally, subsequently converting these compounds to other functional derivatives by appropriate reactions. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US595870A | 1970-01-26 | 1970-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES387542A1 true ES387542A1 (en) | 1974-04-16 |
Family
ID=21718560
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES387542A Expired ES387542A1 (en) | 1970-01-26 | 1971-01-22 | A procedure for the preparation of new acids 2- aroil - pirrol - 2 - carboxylic and its derivatives. (Machine-translation by Google Translate, not legally binding) |
ES416017A Expired ES416017A1 (en) | 1970-01-26 | 1973-06-16 | A procedure for the preparation of new acids 2- aroil-pirrol-2-carboxylics and their derivatives. (Machine-translation by Google Translate, not legally binding) |
ES416015A Expired ES416015A1 (en) | 1970-01-26 | 1973-06-16 | A procedure for the preparation of new acids 2- aroil-pirrol-2-carboxylics and their derivatives. (Machine-translation by Google Translate, not legally binding) |
ES416016A Expired ES416016A1 (en) | 1970-01-26 | 1973-06-16 | A procedure for the preparation of new acids 2- aroil-pirrol-2-carboxylics and their derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES416017A Expired ES416017A1 (en) | 1970-01-26 | 1973-06-16 | A procedure for the preparation of new acids 2- aroil-pirrol-2-carboxylics and their derivatives. (Machine-translation by Google Translate, not legally binding) |
ES416015A Expired ES416015A1 (en) | 1970-01-26 | 1973-06-16 | A procedure for the preparation of new acids 2- aroil-pirrol-2-carboxylics and their derivatives. (Machine-translation by Google Translate, not legally binding) |
ES416016A Expired ES416016A1 (en) | 1970-01-26 | 1973-06-16 | A procedure for the preparation of new acids 2- aroil-pirrol-2-carboxylics and their derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS56426B1 (en) |
CA (1) | CA924728A (en) |
ES (4) | ES387542A1 (en) |
ZA (1) | ZA71470B (en) |
-
1971
- 1971-01-22 ES ES387542A patent/ES387542A1/en not_active Expired
- 1971-01-25 CA CA103535A patent/CA924728A/en not_active Expired
- 1971-01-25 ZA ZA710470A patent/ZA71470B/en unknown
- 1971-01-26 JP JP258971A patent/JPS56426B1/ja active Pending
-
1973
- 1973-06-16 ES ES416017A patent/ES416017A1/en not_active Expired
- 1973-06-16 ES ES416015A patent/ES416015A1/en not_active Expired
- 1973-06-16 ES ES416016A patent/ES416016A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS56426B1 (en) | 1981-01-08 |
ES416015A1 (en) | 1976-02-16 |
ES416016A1 (en) | 1976-02-16 |
ES416017A1 (en) | 1976-02-16 |
CA924728A (en) | 1973-04-17 |
ZA71470B (en) | 1972-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19861007 |