ES383561A1 - A procedure for the preparation of nitromidazoles. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of nitromidazoles. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES383561A1
ES383561A1 ES383561A ES383561A ES383561A1 ES 383561 A1 ES383561 A1 ES 383561A1 ES 383561 A ES383561 A ES 383561A ES 383561 A ES383561 A ES 383561A ES 383561 A1 ES383561 A1 ES 383561A1
Authority
ES
Spain
Prior art keywords
formula
translation
preparation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES383561A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES383561A1 publication Critical patent/ES383561A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the preparation of a 1-methyl-5-nitroimidazol-2-yl (lower) alkyl carbamate of the formula, **(See formula)** where R is hydrogen or lower alkyl, which consists in reacting a 1-methyl-2-hydroxyalkyl (lower) -5-nitroimidazole of formula: **(See formula)** where R is the one defined above, with a carbamate of formula (see formula) where R2 is lower alkyl or phenyl, in the presence of an organic titanate or zirconate transesterification catalyst, of formulas Ti (0R3) 4 and Zr (0R3) 4 respectively, where R3 is an alkyl group of 1 to 6 carbon atoms, benzyl, phenyl or cycloalkyl of 1 to 6 carbon atoms. (Machine-translation by Google Translate, not legally binding)
ES383561A 1969-09-18 1970-09-11 A procedure for the preparation of nitromidazoles. (Machine-translation by Google Translate, not legally binding) Expired ES383561A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85918069A 1969-09-18 1969-09-18

Publications (1)

Publication Number Publication Date
ES383561A1 true ES383561A1 (en) 1973-01-01

Family

ID=25330277

Family Applications (1)

Application Number Title Priority Date Filing Date
ES383561A Expired ES383561A1 (en) 1969-09-18 1970-09-11 A procedure for the preparation of nitromidazoles. (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
CH (1) CH547806A (en)
CS (1) CS170163B2 (en)
ES (1) ES383561A1 (en)
NL (1) NL7010859A (en)
SE (1) SE379042B (en)
YU (1) YU33487B (en)

Also Published As

Publication number Publication date
CS170163B2 (en) 1976-08-27
CH547806A (en) 1974-04-11
NL7010859A (en) 1971-03-22
SE379042B (en) 1975-09-22
YU33487B (en) 1977-04-30
YU223370A (en) 1976-10-31

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