ES380127A1 - Pharmacodynamically effective 10-4-substituted piperazino-10,11- dihydrodibenzo-b,f thiepins and a method of preparing same - Google Patents

Pharmacodynamically effective 10-4-substituted piperazino-10,11- dihydrodibenzo-b,f thiepins and a method of preparing same

Info

Publication number
ES380127A1
ES380127A1 ES380127A ES380127A ES380127A1 ES 380127 A1 ES380127 A1 ES 380127A1 ES 380127 A ES380127 A ES 380127A ES 380127 A ES380127 A ES 380127A ES 380127 A1 ES380127 A1 ES 380127A1
Authority
ES
Spain
Prior art keywords
radical
group
formula
thiepins
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES380127A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spofa Vereinigte Pharma Werke
Original Assignee
Spofa Vereinigte Pharma Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Vereinigte Pharma Werke filed Critical Spofa Vereinigte Pharma Werke
Publication of ES380127A1 publication Critical patent/ES380127A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for the preparation of pharmacodynamically active thiepins, such as 10- [piperazino-substituted] -10,11-dihydrodibenzo [b, f] thiepins of the general formula I **(See formula)** where: R1 signifies a hydrogen or halogen atom, an alcoholic radical R, a trifluoromethyl group, an alkoxy radical OR, an alcoholylthio group SR, an alkanesulfonyl group SO2R, a nitro group or a cyano group; R2 denotes an alcoholic, alkenyl, alkynyl, cycloalkyl, cycloalkoxy-alcohol, aralkoxy, hydroxyalkyl, acyloxyalkyl, dialkoxylaminoalkoxy or alkoxycarbonylalkyl group, where R represents a straight or branched alkenyl hydrocarbon radical with 1 to 4 carbon atoms, radical with 2 to 4 carbon atoms, cycloalkyl representing a cyolopropyl or cyclooctyl radical, acyl representing an aliphatic carboxylic acid radical with 2 to 5 carbon atoms and the aralkoxy radical being able to be substituted in the benzene nucleus with an alcoholic radical, alkoxy, alcoholylthio or trifluoromethyl or with a halogen atom and its salts, characterized in that secondary amines of the general formula II **(See formula)** where R1 means the same as in formula I, they are alcoholized with reactable alcohol esters of the general formula III R2-OH III where R2 also means the same as in formula I, preferably with corresponding halides, alkanesulfonates or arenesulfonates, after which the resulting basic products are transformed into the corresponding salts by neutralization with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
ES380127A 1969-05-28 1970-05-27 Pharmacodynamically effective 10-4-substituted piperazino-10,11- dihydrodibenzo-b,f thiepins and a method of preparing same Expired ES380127A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS380369 1969-05-28

Publications (1)

Publication Number Publication Date
ES380127A1 true ES380127A1 (en) 1973-04-16

Family

ID=5379169

Family Applications (1)

Application Number Title Priority Date Filing Date
ES380127A Expired ES380127A1 (en) 1969-05-28 1970-05-27 Pharmacodynamically effective 10-4-substituted piperazino-10,11- dihydrodibenzo-b,f thiepins and a method of preparing same

Country Status (9)

Country Link
AT (1) AT306726B (en)
BE (1) BE750883A (en)
CA (1) CA965420A (en)
CH (1) CH550196A (en)
DE (1) DE2026027A1 (en)
ES (1) ES380127A1 (en)
FR (1) FR2043741A1 (en)
GB (1) GB1313428A (en)
NL (1) NL7007759A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH555856A (en) * 1971-05-04 1974-11-15 Hoffmann La Roche METHOD FOR PRODUCING TRICYCLIC COMPOUNDS.
US3996229A (en) * 1974-01-14 1976-12-07 Hoffmann-La Roche Inc. 1-[10,11-Dihydro-dibenzo[b,f]-thiepin-10-yl]-4-(alkynylalkyl)-piperazines
US5602121A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. Alkyl-substituted compounds having dopamine receptor affinity
WO2019092044A1 (en) * 2017-11-08 2019-05-16 Centre National De La Recherche Scientifique Dihydrobenzo[b][1]benzothiepin compounds useful in therapy

Also Published As

Publication number Publication date
CA965420A (en) 1975-04-01
GB1313428A (en) 1973-04-11
BE750883A (en) 1970-11-03
NL7007759A (en) 1970-12-01
AT306726B (en) 1973-04-25
FR2043741A1 (en) 1971-02-19
DE2026027A1 (en) 1970-12-03
CH550196A (en) 1974-06-14

Similar Documents

Publication Publication Date Title
ES370394A1 (en) 11-substituted 5 11-dihydro-6h-pyrido(2 3-b)(1 4)benzodiazepin-6-ones
ES380127A1 (en) Pharmacodynamically effective 10-4-substituted piperazino-10,11- dihydrodibenzo-b,f thiepins and a method of preparing same
SE7500871L (en) PROCEDURE FOR THE PREPARATION OF 3-METHYLENCE PHALOSPORT ASSOCIATIONS
SE7607300L (en) THIAXANTENE ASSOCIATIONS AND PROCEDURES FOR THE PREPARATION OF THEM
GB1085672A (en) Substituted phthalazines
ATE32462T1 (en) TRIAZOLOPYRIMIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR THERAPEUTIC APPLICATION AS CARDIOTONICS.
FR2346303A1 (en) PROCESS FOR PREPARING USEFUL REFRACTORY MATERIALS IN THE FORM OF NUCLEAR FUEL
ES405647A1 (en) Procedure for the preparation of new acids 4- (4 bifenilil) -44-hydroxy-butirrics, its esters or lactons. (Machine-translation by Google Translate, not legally binding)
FR2305976A1 (en) D-HOMOSTEROIDES AND PROCESS FOR THEIR PREPARATION
ES402648A1 (en) Hydroxycrotonic acid derivatives
ES406131A1 (en) Procedure for the preparation of acids 4- (4-bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES382843A1 (en) Basic derivatives of 5h-dibenz(b,f) azepines
ES432465A1 (en) Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
GB894049A (en) Method of preparing 10-(1-substituted-3-pyrrolidylmethyl) phenothiazines
ES382848A1 (en) Procedure for the preparation of new basic derivatives of 5h-dibenz (b, f) azepine. (Machine-translation by Google Translate, not legally binding)
ES382849A1 (en) Procedure for the preparation of new derivatives of 5h-dibenz (b, f,) azepine. (Machine-translation by Google Translate, not legally binding)
ES380557A1 (en) Benzodiazepines the preparation thereof and compositions containing the same
ES450125A1 (en) 6,11-dihydro-11 - oxodibenzyloxepinealkanoic acids and esters
ES373930A1 (en) Procedure for the preparation of new derivatives of azepine. (Machine-translation by Google Translate, not legally binding)
ATE7497T1 (en) IMIDAZODIAZEPIN DERIVATIVES, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR MANUFACTURE, PHARMACEUTICALS CONTAINING THEM AND THEIR THERAPEUTIC USE.
ES384598A1 (en) Procedure for the preparation of new basic pirrol derivatives. (Machine-translation by Google Translate, not legally binding)
ES386685A1 (en) Process for the preparation of benzophenone derivatives
ES489664A1 (en) Lysine salt of (+/-) 3-amino-4-(1-pyrrolyl)-alpha-methylphenyl-acetic acid, process for its preparation and pharmaceutical composition containing it.
GB973577A (en) Yohimbane derivatives and a process for their preparation
ES398222A1 (en) Benzodiazepine derivatives and a process for the manjfacture thereof