ES377906A1 - New tricyclic derivatives and process for their manufacture - Google Patents

New tricyclic derivatives and process for their manufacture

Info

Publication number
ES377906A1
ES377906A1 ES377906A ES377906A ES377906A1 ES 377906 A1 ES377906 A1 ES 377906A1 ES 377906 A ES377906 A ES 377906A ES 377906 A ES377906 A ES 377906A ES 377906 A1 ES377906 A1 ES 377906A1
Authority
ES
Spain
Prior art keywords
general formula
alkyl group
resulting
acid
formula above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES377906A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of ES377906A1 publication Critical patent/ES377906A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/16—Eight-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Novel tricyclic compounds of the general formula wherein A is -(CH 2 ) m -, -CH=CH-, -(CH 2 ) p O-, -(CH 2 ) p S-, -(CH 2 ) p SO 2 -, -(CH 2 ) p NR 1 - or -SO 2 NR 2 -, in which m is 1, 2 or 3, p is 1 or 2, R 1 is a hydrogen atom or a C 1-5 alkyl group and R 2 is a C 1-5 alkyl group, X and Y are each a hydrogen or halogen atom, R and R1 are each a hydrogen atom or a C 1-5 alkyl group and n is an integer from 1 to 12 inclusive, and salts thereof are prepared by condensation of an aminoalkanoic acid ester of the general formula RNH(CH 2 ) n COOR1, wherein R1 is a C 1-5 alkyl group, with a halide of the general formula wherein Hal is a chlorine or bromine atom, and optional saponification of the resulting ester of the first general formula above to give the corresponding free acid, followed optionally by salification of the product with an acid or base. Halides of the third general formula above are prepared by cyclization of a suitable o- (phenyl-A)-benzoic acid, reduction of the resulting tricyclic ketone and halogenation of the resulting hydroxy compound. Pharmaceutical compositions having psychostimulant, antidepressive, analgesic, antitussive, antihistaminic and gastric antisecretory activity comprise, as active ingredient, a tricyclic compound of the first general formula above or a physiologically tolerable salt thereof, together with a pharmaceutically suitable carrier, and may be administered orally, rectally or parenterally.
ES377906A 1969-03-27 1970-03-24 New tricyclic derivatives and process for their manufacture Expired ES377906A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1611669A GB1269551A (en) 1969-03-27 1969-03-27 New tricyclic derivatives and process for their manufacture

Publications (1)

Publication Number Publication Date
ES377906A1 true ES377906A1 (en) 1972-06-16

Family

ID=10071471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES377906A Expired ES377906A1 (en) 1969-03-27 1970-03-24 New tricyclic derivatives and process for their manufacture

Country Status (9)

Country Link
BE (1) BE748032A (en)
CH (1) CH522595A (en)
DE (3) DE2011806C3 (en)
DK (1) DK133976B (en)
ES (1) ES377906A1 (en)
FR (3) FR2037266B1 (en)
GB (1) GB1269551A (en)
NL (1) NL140526B (en)
SE (2) SE368005B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH629667A5 (en) * 1978-03-28 1982-05-14 Science Union & Cie PHARMACEUTICAL COMPOSITION ACTING ON GASTROINTESTINAL MOTORITY.
FR2594827B1 (en) * 1986-02-21 1988-05-20 Adir NEW TRICYCLIC DERIVATIVE ACID ((CHLORO-3 METHYL-6 DIOXO-5.5 DIHYDRO-6, 11 DIBENZO (C, F) THIAZEPINE (1,2) YL-11 AMINO) -5 PENTAZOIQUE, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
JPH0578292A (en) * 1991-04-05 1993-03-30 Hokuriku Seiyaku Co Ltd Tricyclic compound
FR2716623B1 (en) 1994-02-25 1996-08-23 Adir Use of a tricyclic derivative for obtaining medicaments intended for the treatment of mnemo-cognitive disorders.
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
FR2807039A1 (en) 2000-03-31 2001-10-05 Adir NOVEL PROCESS FOR THE PREPARATION OF 11-AMINO-3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO [c, f] [1,2] -THIAZEPINE AND APPLICATION TO THE SYNTHESIS OF TIANEPTINE
US6683072B1 (en) 2003-02-04 2004-01-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia
EP1611888A1 (en) * 2003-03-31 2006-01-04 Kyowa Hakko Kogyo Co., Ltd. Antitussives
EP2222342B1 (en) * 2007-11-28 2014-03-26 Nektar Therapeutics Oligomer-tricyclic conjugates
US8198268B2 (en) 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
WO2010070667A2 (en) * 2008-11-19 2010-06-24 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate
US8355927B2 (en) 2010-11-05 2013-01-15 Genomind, Llc Neuropsychiatric test reports
GB201106520D0 (en) 2011-04-18 2011-06-01 Numedicus Ltd Pharmaceutical compounds
ITMI20111308A1 (en) * 2011-07-14 2013-01-15 Cosma S P A METHOD OF PREPARATION OF TIANEPTINA SALE SODICO
PL2561864T3 (en) 2011-08-25 2015-05-29 Zakl Farmaceutyczne Polpharma Sa Coated tablet comprising tianeptine and process for preparation thereof
BRPI1104695B1 (en) * 2011-09-02 2020-10-27 Universidade Federal Do Rio Grande Do Sul tianeptine derivatives, pharmaceutical compositions, use, and process for their production
CN104023727B (en) 2011-10-28 2017-04-05 鲁美纳医药公司 For treating the bile acid recycling inhibitors of children's cholestatic liver disease
GB201208315D0 (en) 2012-05-11 2012-06-27 Numedicus Ltd Pharmaceutical methods and compositions
AU2015229258B2 (en) * 2014-03-12 2020-01-30 The Trustees Of Columbia University In The City Of New York A new class of Mu-Opioid receptor agonists
US10844027B2 (en) 2015-09-16 2020-11-24 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
KR102199871B1 (en) 2018-12-21 2021-01-08 주식회사 한서켐 A process for preparing 3,11-Dichloro-6-methyl -6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543035A1 (en) * 1965-01-06 1969-09-25 Hoffmann La Roche Process for the preparation of dibenzocycloheptene compounds

Also Published As

Publication number Publication date
NL7003429A (en) 1970-09-29
BE748032A (en) 1970-09-28
DE2011806C3 (en) 1981-12-03
DE2065636C3 (en) 1979-07-19
DE2065636B2 (en) 1978-11-16
FR2104729B1 (en) 1974-05-24
DE2065636A1 (en) 1974-12-19
DE2065635A1 (en) 1974-09-05
NL140526B (en) 1973-12-17
FR2037266A1 (en) 1970-12-31
DK133976B (en) 1976-08-23
DE2011806A1 (en) 1970-10-15
DE2065635B2 (en) 1979-02-08
DK133976C (en) 1977-03-21
FR2037266B1 (en) 1974-05-24
DE2065635C3 (en) 1979-10-04
CH522595A (en) 1972-06-30
DE2011806B2 (en) 1981-01-08
SE402104B (en) 1978-06-19
SE368005B (en) 1974-06-17
FR2104729A1 (en) 1972-04-21
FR2104728A1 (en) 1972-04-21
FR2104728B1 (en) 1974-05-24
GB1269551A (en) 1972-04-06

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