ES372357A1 - Amino-Acids containing Thioether Groups and their Derivatives - Google Patents

Amino-Acids containing Thioether Groups and their Derivatives

Info

Publication number
ES372357A1
ES372357A1 ES372357A ES372357A ES372357A1 ES 372357 A1 ES372357 A1 ES 372357A1 ES 372357 A ES372357 A ES 372357A ES 372357 A ES372357 A ES 372357A ES 372357 A1 ES372357 A1 ES 372357A1
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
amino
phenyl
anilino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES372357A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES372357A1 publication Critical patent/ES372357A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Manufacture And Refinement Of Metals (AREA)

Abstract

Pharmaceutical preparations useful in the treatment of inflammation contain as active ingredient compounds I (including optically active isomers and acid addition salts thereof and symmetrical anhydrides of comounds I in which R 2 is hydroxy) where n is 1, 2 or 3, R signifies H, halogen, SH, CN, C 1 _ 5 alkylsulphonyl, C 1 _ 5 alkylsulphinyl, C 1 _ 6 alkanoyl, trifluoroacetyl, C 1 _ 5 haloalkyl, SO 2 NH 2 , di(C 1 _ 5 alkyl), sulphamoyl, CONH 2 , di(C 1 _ 5 alkyl) carbamoyl, OH, C 1 _ 5 alkylthio, C 1 _ 5 alkoxy, anisyl, phenyl, NO 2 , phenethyl, C 1 _ 5 alkyl, methylenedioxy, anilino, N-(C 1 _ 5 alkyl) anilino, (C 1 _ 5 alkyl) phenyl, di(C 1 _ 5 alkyl) amino, cyclohexyl, iphenoxy, NH 2 , acylamino, C 1 _ 5 alkylamino or C 2 _ 5 alkenyl, R 2 signifies OH C 1 _ 5 alkoxy, C 2 _ 5 alkenyloxy, C 2 _ 5 alkynyloxy, cyclopropylmethyloxy, (C 1-5 alkoxy)-(C 1-5 alkoxy), poly (C 1-5 alkoxy)-(C 1-5 alkoxy), di(C 1-5 alkylamino)-(C 1-5 alkoxy), piperidino-(C 1-5 alkoxy), 1 pyrrolidinyl-(C 1-5 alkoxy), morpholino-(C 1-5 alkoxy), [1- (C 1-5 alkyl)-2-pyrrolidinyl]-[C 1-5 alkoxy], [-1-C 1-5 alkyl)-2-piperidinyl]-[C 1-5 alkoxy], N-(C 1-5 alkyl) -N-piperazinyl-(C 1-5 alkoxy), phenoxy, p-(C 1-6 alkanoyl) aminophenoxy, phenyl-(C 1-5 alkoxy) carhamoylphenoxy, (C 1-5, alkoxyphenyl)-(C 1-5 alkoxy), phenyl-(C 2-5 alkenyloxy), tetrahydrofurfuryloxy, di(C 1-5 alkyl) amino-cyclohexyloxy, NH 2 , C 1-5 alkylamino, di(C 1-5 alkyl) amino, glucosamino, glycosylamino, (C 2-5 alkenyl) amino, phenyl (C 1-5 alkyl) amino, haloanilino, [1-(C 1-5 alkyl) piperidinyl-2]-[C 1-5 alkyl] amino, tetrahydrofurfurylamino, 1, 2, 5, 6-tetrahydropyridino, morpholino, N'-(C 1-5 alkyl)-N-PiPerazinyl, piperazino, N-phenyl-piperazino, piperidino, benzylamino, anilino, (C 1-5 alkoxy) anilino, C 3-6 cycloalkylamino, pyrrolidino, N- (C 1-5 hydroxyalkyl)-piperazino, N,N-di(C 1-5 alkyl) carbamoyl-(C 1-5 alkyl)-amino, N,N-di (C 1-5 alkyl) amino-(C 1-5 alkyl) amino, [1-(C 1-5 alkyl) 1 pyrrolidino-2]-[C 1-5 alkylamino], N-carbobenzyloxy-C 1-5 alkyl) amino, or an OZ radical where Z is a cation, R 1 , R 3 and R 3 signify H, C 1-5 alkyl or phenyl, each of R 4 and R 5 is H, C 1-5 alkyl, C 1-6 alkanoyl or phenyl or R 4 is guanyl and R 5 is H, and R 6 and R 6 ' signify H, C 1-5 alkyl, C 2-5 alkenyl, phenyl, naphthyl, thienyl or pyridyl or substituted phenyl ornaphthyl wherein the substituents are (R) n . salicylates, e.g. aspirin, may also be incorporated into the preparations. Administration is, e.g. in the form of tablets, pills, powders, capsules, elixirs and injectable liquids.
ES372357A 1967-07-26 1969-10-09 Amino-Acids containing Thioether Groups and their Derivatives Expired ES372357A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65604167A 1967-07-26 1967-07-26
US72835168A 1968-05-10 1968-05-10

Publications (1)

Publication Number Publication Date
ES372357A1 true ES372357A1 (en) 1972-01-16

Family

ID=27097099

Family Applications (4)

Application Number Title Priority Date Filing Date
ES356488A Expired ES356488A1 (en) 1967-07-26 1968-07-24 Amino-Acids containing Thioether Groups and their Derivatives
ES372358A Expired ES372358A1 (en) 1967-07-26 1969-10-09 Amino-Acids containing Thioether Groups and their Derivatives
ES372359A Expired ES372359A1 (en) 1967-07-26 1969-10-09 Amino-Acids containing Thioether Groups and their Derivatives
ES372357A Expired ES372357A1 (en) 1967-07-26 1969-10-09 Amino-Acids containing Thioether Groups and their Derivatives

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES356488A Expired ES356488A1 (en) 1967-07-26 1968-07-24 Amino-Acids containing Thioether Groups and their Derivatives
ES372358A Expired ES372358A1 (en) 1967-07-26 1969-10-09 Amino-Acids containing Thioether Groups and their Derivatives
ES372359A Expired ES372359A1 (en) 1967-07-26 1969-10-09 Amino-Acids containing Thioether Groups and their Derivatives

Country Status (12)

Country Link
JP (1) JPS5019543B1 (en)
BE (1) BE718559A (en)
CH (1) CH534138A (en)
DE (1) DE1768964A1 (en)
ES (4) ES356488A1 (en)
FR (2) FR1586146A (en)
GB (1) GB1191042A (en)
IE (1) IE32515B1 (en)
IL (1) IL30369A (en)
NL (1) NL144484B (en)
NO (1) NO124205B (en)
SE (1) SE364040B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE733993A (en) * 1968-06-14 1969-12-03
US4315031A (en) * 1977-09-01 1982-02-09 Science Union Et Cie Thiosubstituted amino acids
FR2434149A1 (en) * 1978-06-22 1980-03-21 Parcor NEW L-CYSTEIN DERIVATIVES
US4246263A (en) * 1979-10-15 1981-01-20 Pfizer Inc. Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
DE3303344A1 (en) * 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED AMINO ACIDS AND THEIR ESTERS
DE10045831A1 (en) * 2000-09-14 2002-04-04 Gruenenthal Gmbh Anticonvulsant, anxiolytic and especially analgesic medicaments, comprising new or known beta-thio-alpha-aminoacid compounds having strong affinity for gabapentin binding site
DK1317426T3 (en) 2000-09-14 2006-01-09 Gruenenthal Gmbh Pay-thio-amino acids
US9664138B2 (en) 2010-12-29 2017-05-30 Ford Global Technologies, Llc Cylinder block

Also Published As

Publication number Publication date
NO124205B (en) 1972-03-20
BE718559A (en) 1969-01-27
IE32515B1 (en) 1973-09-05
GB1191042A (en) 1970-05-06
FR1586146A (en) 1970-02-13
NL144484B (en) 1975-01-15
NL6809834A (en) 1969-01-28
JPS5019543B1 (en) 1975-07-08
ES372359A1 (en) 1971-10-16
IL30369A0 (en) 1968-09-26
FR7960M (en) 1970-06-01
SE364040B (en) 1974-02-11
CH534138A (en) 1973-02-28
ES372358A1 (en) 1971-10-16
IL30369A (en) 1973-08-29
DE1768964A1 (en) 1972-01-27
IE32515L (en) 1969-01-26
ES356488A1 (en) 1970-04-01

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