IE32515B1 - Amino-acids containing thioether groups and their derivatives - Google Patents
Amino-acids containing thioether groups and their derivativesInfo
- Publication number
- IE32515B1 IE32515B1 IE849/68A IE84968A IE32515B1 IE 32515 B1 IE32515 B1 IE 32515B1 IE 849/68 A IE849/68 A IE 849/68A IE 84968 A IE84968 A IE 84968A IE 32515 B1 IE32515 B1 IE 32515B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- cpds
- alkenyl
- alkanoyl
- alkylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/56—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Pyridine Compounds (AREA)
Abstract
Process for cpds. of formula (I), and some cpds. (I): R = H, halogen, SH, CN, SO2alkyl, SO alkyl, alkanoyl, CF3CO, haloalkyl, SO2NH2, SO2N(alkyl)2, CONH2, CON(alkyl)2, OH, S-alkyl, O-alkyl, anisyl, Ph, NO2, phenethyl, alkyl, OCH2O, PhNH-, PhN(alkyl)-, alkylphenyl, N(alkyl)2, cyclohenyl, PhO, NH2, NHacyl, NHalkyl, or alkenyl. R may be substd. by Ph or naphthyl. R2 = OH, O-alkyl, O-alkenyl, O-alkynyl, cyclopropyl-methyloxy, alkoxyalkoxy, polyalkoxyalkoxy, dialkyl-aminoalkoxy, piperidinoalkoxy, 1-pyrrolidenylalkoxy, morpholinoalkoxy, 1-alkyl-2-pyrolidinyalkoxy, 1-alkyl-2-piperidino-alkoxy, N'-alkyl-N-piperazinyl-alkoxy, PhO, p-alkanoylaminophenoxy, phenylalkoxy, carbamylphenoxy, tetrahydrofurfuryloxy, dialkylamino-cyclohexyloxy, NH2, NHalkyl, N(alkyl)2, glucosamino, glycosylamino, alkenylamino, phenylalkylamino, haloanilino, 1-alkylpiperidinyl-2-alkylamino, tetrahydrofuryfurylamino, 1,2,5,6-tetrahydropyridino, morpholino, N'-alkyl-N-piperazinyl, piperazino, N-phenylpiperazino, piperidino, benzylamino, PhNH2, alkoxyanilino, NH(cycloalkyl), pyrrolidino, N-hydroxyalkylpiperazino, N, N-dialkylcarbamyl-alkylamino-, N, N-dialkylaminoalkylamino, 1-alkyl-pyrrolidino 2-alkylamino, N-carbobenzyloxyalkylamino, or a group OZ, where Z is a cation or the acyl portion of I(R2=OH). R',R3,R7=H, alkyl or Ph; R4,R5 = H, alkyl, alkanoyl, Ph, or guanyl if R5=H; R6,R8 = H, alkyl, alkenyl, Ph or -naphthyl opt. substd. by R, thienyl, pyridyl. Cpds. (I) are new provided that (a) if R6 and R8 = Ph, at least 1 of R, R', R3, R4, R5, R7 is not = H, and R2 is as above. (b) If R8 = Ph, at least one of R', R3, R4, R5, R6, R7, is not = H when R=H or Oalkyl and is any a single substit. (c) If R8 = H, and R=H, Hal, Oalkyl, NO2, or alkenyl, and is a single substit., then at least one of R', R3, R4, R5, R6, R7 is not = H. (d) If R4 = alkanoyl, at least one of R, R', R3, R5, R6, R7 is not = H, while R2 is as above and R8=H. Also the corr. cpds. III, IV, V, and process for II.
[CH534138A]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65604167A | 1967-07-26 | 1967-07-26 | |
US72835168A | 1968-05-10 | 1968-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE32515L IE32515L (en) | 1969-01-26 |
IE32515B1 true IE32515B1 (en) | 1973-09-05 |
Family
ID=27097099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE849/68A IE32515B1 (en) | 1967-07-26 | 1968-07-16 | Amino-acids containing thioether groups and their derivatives |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS5019543B1 (en) |
BE (1) | BE718559A (en) |
CH (1) | CH534138A (en) |
DE (1) | DE1768964A1 (en) |
ES (4) | ES356488A1 (en) |
FR (2) | FR1586146A (en) |
GB (1) | GB1191042A (en) |
IE (1) | IE32515B1 (en) |
IL (1) | IL30369A (en) |
NL (1) | NL144484B (en) |
NO (1) | NO124205B (en) |
SE (1) | SE364040B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE733993A (en) * | 1968-06-14 | 1969-12-03 | ||
US4315031A (en) * | 1977-09-01 | 1982-02-09 | Science Union Et Cie | Thiosubstituted amino acids |
FR2434149A1 (en) * | 1978-06-22 | 1980-03-21 | Parcor | NEW L-CYSTEIN DERIVATIVES |
US4246263A (en) * | 1979-10-15 | 1981-01-20 | Pfizer Inc. | Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions |
DE3303344A1 (en) * | 1983-02-02 | 1984-08-02 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED AMINO ACIDS AND THEIR ESTERS |
DE10045831A1 (en) * | 2000-09-14 | 2002-04-04 | Gruenenthal Gmbh | Anticonvulsant, anxiolytic and especially analgesic medicaments, comprising new or known beta-thio-alpha-aminoacid compounds having strong affinity for gabapentin binding site |
MXPA03002090A (en) | 2000-09-14 | 2003-06-19 | Gruenenthal Gmbh | szlig;-THIO-AMINO ACIDS. |
US8833328B2 (en) | 2010-12-29 | 2014-09-16 | Ford Global Technologies, Llc | Structural frame |
-
1968
- 1968-07-11 NL NL686809834A patent/NL144484B/en not_active IP Right Cessation
- 1968-07-15 NO NO2800/68A patent/NO124205B/no unknown
- 1968-07-15 IL IL30369A patent/IL30369A/en unknown
- 1968-07-16 IE IE849/68A patent/IE32515B1/en unknown
- 1968-07-17 SE SE09792/68A patent/SE364040B/xx unknown
- 1968-07-18 DE DE19681768964 patent/DE1768964A1/en active Pending
- 1968-07-22 GB GB34780/68A patent/GB1191042A/en not_active Expired
- 1968-07-24 ES ES356488A patent/ES356488A1/en not_active Expired
- 1968-07-25 FR FR1586146D patent/FR1586146A/fr not_active Expired
- 1968-07-25 CH CH1113468A patent/CH534138A/en not_active IP Right Cessation
- 1968-07-25 FR FR160545A patent/FR7960M/fr not_active Expired
- 1968-07-25 JP JP43052196A patent/JPS5019543B1/ja active Pending
- 1968-07-25 BE BE718559D patent/BE718559A/xx not_active Expired
-
1969
- 1969-10-09 ES ES372357A patent/ES372357A1/en not_active Expired
- 1969-10-09 ES ES372358A patent/ES372358A1/en not_active Expired
- 1969-10-09 ES ES372359A patent/ES372359A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB1191042A (en) | 1970-05-06 |
NO124205B (en) | 1972-03-20 |
CH534138A (en) | 1973-02-28 |
BE718559A (en) | 1969-01-27 |
DE1768964A1 (en) | 1972-01-27 |
IE32515L (en) | 1969-01-26 |
SE364040B (en) | 1974-02-11 |
JPS5019543B1 (en) | 1975-07-08 |
IL30369A0 (en) | 1968-09-26 |
ES372357A1 (en) | 1972-01-16 |
FR1586146A (en) | 1970-02-13 |
NL144484B (en) | 1975-01-15 |
ES372358A1 (en) | 1971-10-16 |
ES372359A1 (en) | 1971-10-16 |
NL6809834A (en) | 1969-01-28 |
IL30369A (en) | 1973-08-29 |
FR7960M (en) | 1970-06-01 |
ES356488A1 (en) | 1970-04-01 |
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