ES367839A1 - Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES367839A1
ES367839A1 ES367839A ES367839A ES367839A1 ES 367839 A1 ES367839 A1 ES 367839A1 ES 367839 A ES367839 A ES 367839A ES 367839 A ES367839 A ES 367839A ES 367839 A1 ES367839 A1 ES 367839A1
Authority
ES
Spain
Prior art keywords
compound
compounds
translation
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES367839A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES367839A1 publication Critical patent/ES367839A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Novel compounds I in which R is a C 1-6 alkyl group X is O or S Y 1 and Y 2 are H or CH 3 and Z 1 and Z 2 are H, F, Cl, Br, CH 3 , C 2 H 5 , CH 3 O or C 2 H 5 O, and their salts with bases are prepared (a) by splitting off H-Am from a compound II in which Am is a secondary amino radical (b) by reacting the appropriate 5-unsubstituted compound with an acid halide where Cl is halo or an anhydride or (c) by dehalogenating a compound III where Cl is halo, followed if desired by salt formation. Intermediates isolated are the compounds II, prepared by reaction of the appropriate compounds which compounds are described in Specification 1,265,882 with formaldehyde or paraformaldehyde and H-Am and 2,3-dihydro- 5 ( 2 - bromo - 2 - bromomethyl - butyryl) - 6 - methylbenzofuran-2-carboxylic acid, prepared from the 5-unsubstituted compound and 2-bromo-2- bromomethyl-butyryl chloride. Pharmaceutical compositions comprise a compound I in association with a suitable carrier, are administered orally and have diuretic and saluretic activity.
ES367839A 1968-05-30 1969-05-29 Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding) Expired ES367839A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH803268A CH510007A (en) 1968-05-30 1968-05-30 Process for the preparation of new heterocyclic carboxylic acids

Publications (1)

Publication Number Publication Date
ES367839A1 true ES367839A1 (en) 1971-04-16

Family

ID=4334103

Family Applications (3)

Application Number Title Priority Date Filing Date
ES367838A Expired ES367838A1 (en) 1968-05-30 1969-05-29 Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding)
ES367840A Expired ES367840A1 (en) 1968-05-30 1969-05-29 Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding)
ES367839A Expired ES367839A1 (en) 1968-05-30 1969-05-29 Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES367838A Expired ES367838A1 (en) 1968-05-30 1969-05-29 Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding)
ES367840A Expired ES367840A1 (en) 1968-05-30 1969-05-29 Procedure for the preparation of new heterociclic carboxylic acids. (Machine-translation by Google Translate, not legally binding)

Country Status (19)

Country Link
AT (3) AT289782B (en)
BE (1) BE733769A (en)
BG (3) BG15576A3 (en)
BR (1) BR6909330D0 (en)
CH (3) CH510007A (en)
CS (3) CS158645B2 (en)
DE (1) DE1927452C3 (en)
DK (1) DK122607B (en)
ES (3) ES367838A1 (en)
FI (1) FI49417C (en)
FR (1) FR2009653A1 (en)
GB (1) GB1266766A (en)
IE (1) IE33125B1 (en)
IL (1) IL32311A (en)
NL (1) NL6907974A (en)
NO (1) NO122754B (en)
SE (1) SE360859B (en)
SU (1) SU402220A3 (en)
YU (1) YU34041B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756105A (en) * 1969-09-15 1971-03-15 Geigy Ag J R NEW HETEROCYCLIC CARBOXYLIC ACIDS AND MEDICINES CONTAINING SUCH ACIDS
BE759137R (en) * 1969-11-20 1971-05-19 Geigy Ag J R HETEROCYCLIC CARBOXYLIC ACIDS AND MEDICINAL PRODUCTS CONTAINING SUCH
BE759138A (en) * 1969-11-20 1971-05-19 Geigy Ag J R BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING SUCH SUBSTANCES
JPS61158976A (en) * 1984-12-28 1986-07-18 Shionogi & Co Ltd Benzofuran and benzothiophene derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE624749A (en) * 1961-11-14

Also Published As

Publication number Publication date
IE33125L (en) 1969-11-30
FR2009653A1 (en) 1970-02-06
YU133569A (en) 1978-05-15
DE1927452A1 (en) 1969-12-04
ES367838A1 (en) 1971-04-16
BG15224A3 (en) 1975-11-21
IL32311A0 (en) 1969-07-30
FI49417B (en) 1975-02-28
CH510009A (en) 1971-07-15
BG15576A3 (en) 1972-05-20
CH510008A (en) 1971-07-15
CS158643B2 (en) 1974-11-25
GB1266766A (en) 1972-03-15
IE33125B1 (en) 1974-03-20
BG16178A3 (en) 1972-07-20
BR6909330D0 (en) 1973-02-08
ES367840A1 (en) 1971-04-16
DE1927452C3 (en) 1978-10-12
YU34041B (en) 1978-10-31
DK122607B (en) 1972-03-20
FI49417C (en) 1975-06-10
CH510007A (en) 1971-07-15
AT289782B (en) 1971-05-10
BE733769A (en) 1969-12-01
CS158644B2 (en) 1974-11-25
AT289783B (en) 1971-05-10
AT286285B (en) 1970-12-10
SE360859B (en) 1973-10-08
SU402220A3 (en) 1973-10-12
NL6907974A (en) 1969-12-02
CS158645B2 (en) 1974-11-25
DE1927452B2 (en) 1978-02-02
NO122754B (en) 1971-08-09
IL32311A (en) 1972-09-28

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