ES358795A1 - Procedure for the preparation of di-N-oxidos- (1,4) quinovalinas 3-carboxamidas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of di-N-oxidos- (1,4) quinovalinas 3-carboxamidas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES358795A1 ES358795A1 ES358795A ES358795A ES358795A1 ES 358795 A1 ES358795 A1 ES 358795A1 ES 358795 A ES358795 A ES 358795A ES 358795 A ES358795 A ES 358795A ES 358795 A1 ES358795 A1 ES 358795A1
- Authority
- ES
- Spain
- Prior art keywords
- atom
- quinoxaline
- general formula
- carboxylic acid
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel quinoxaline - 1,4 - di - N - oxide - 3 - carboxylic acid amides of the general formula wherein R 1 is a hydrogen or chlorine atom or a C 1-4 alkyl or C 1-4 alkoxy group R 2 is a hydrogen atom or an alkyl group which may be substituted by a hydroxy, C 1-4 alkoxy, carbalkoxy, acyloxy or mono- or di-alkylamino radical R 3 is a hydrogen atom or an alkyl group which may be substituted by a hydroxy, C 1-4 alkoxy, carbalkoxy, acyloxy or mono- or di-alkylamino radical or, when R 2 is a hydrogen atom, a cyclohexyl group or R 2 and R 3 , together with the nitrogen atom to which they are attached, form a 5- or 6-membered saturated ring, optionally containing an oxygen atom or a further nitrogen atom, the latter optionally carrying a C 1-4 alkyl group which may be substituted by a hydroxy, methoxy or acetoxy group R 4 is an alkyl group which may be substituted by a halogen atom or a phenyl group which may be substituted by a hydroxy, methoxy or acetoxy radical and X is an oxygen or sulphur atom are prepared (a) by reaction of a 2-halomethyl-quinoxaline-1,4-di- N-oxide-3-carboxylic acid amide of the general formula wherein Hal is a chlorine or bromine atom, with a salt of the general formula R 4 COXM, wherein M is a sodium, potassium or ammonium ion, in an organic solvent at 40-160 C. or (b), when X is an oxygen atom, by oxidation of a quinoxaline-3-carboxylic acid amide of the general formula with hydrogen peroxide in the presence of glacial acetic acid or acetic anhydride, or with an organic per-acid. 2 - Halomethyl - quinoxaline - 1,4 - di - N- oxide-3-carboxylic acid amides of the second general formula above are prepared by halogenation of 2 - methyl - quinoxaline - 1,4- di-N-oxide-3-carboxylic acid amides. Pharmaceutical compositions having antibacterial activity comprise, as active ingredient, a quinoxaline-1,4-di-N-oxide-3-carboxylic acid amide of the first general formula above, in admixture with a solid or liquid diluent or carrier, and may be administered orally, rectally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1670936A DE1670936C3 (en) | 1967-10-04 | 1967-10-04 | 3-carboxamido-quinoxaline-di-Nojdde-0,4), a process for their preparation and antibacterial agents containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES358795A1 true ES358795A1 (en) | 1970-05-01 |
Family
ID=7106502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES358795A Expired ES358795A1 (en) | 1967-10-04 | 1968-10-04 | Procedure for the preparation of di-N-oxidos- (1,4) quinovalinas 3-carboxamidas. (Machine-translation by Google Translate, not legally binding) |
Country Status (14)
| Country | Link |
|---|---|
| AT (1) | AT281837B (en) |
| BE (1) | BE721725A (en) |
| CH (1) | CH513185A (en) |
| DE (1) | DE1670936C3 (en) |
| DK (1) | DK128679B (en) |
| ES (1) | ES358795A1 (en) |
| FI (1) | FI49722C (en) |
| FR (2) | FR1597550A (en) |
| GB (1) | GB1231594A (en) |
| IL (1) | IL30714A (en) |
| NL (1) | NL160555C (en) |
| NO (1) | NO122019B (en) |
| SE (1) | SE344463B (en) |
| YU (1) | YU32939B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH538488A (en) * | 1969-12-12 | 1973-06-30 | Hoffmann La Roche | Process for the preparation of heterocyclic compounds |
-
1967
- 1967-10-04 DE DE1670936A patent/DE1670936C3/en not_active Expired
-
1968
- 1968-09-16 IL IL30714A patent/IL30714A/en unknown
- 1968-09-16 CH CH1387868A patent/CH513185A/en not_active IP Right Cessation
- 1968-09-28 NO NO3854/68A patent/NO122019B/no unknown
- 1968-10-02 YU YU2299/68A patent/YU32939B/en unknown
- 1968-10-02 BE BE721725D patent/BE721725A/xx unknown
- 1968-10-02 SE SE13326/68A patent/SE344463B/xx unknown
- 1968-10-03 GB GB1231594D patent/GB1231594A/en not_active Expired
- 1968-10-03 AT AT964468A patent/AT281837B/en not_active IP Right Cessation
- 1968-10-03 DK DK478368AA patent/DK128679B/en unknown
- 1968-10-04 FI FI682817A patent/FI49722C/en active
- 1968-10-04 ES ES358795A patent/ES358795A1/en not_active Expired
- 1968-10-04 FR FR1597550D patent/FR1597550A/fr not_active Expired
- 1968-10-04 NL NL6814260.A patent/NL160555C/en active
- 1968-12-30 FR FR181598A patent/FR8124M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL30714A (en) | 1972-05-30 |
| DE1670936B2 (en) | 1978-06-08 |
| GB1231594A (en) | 1971-05-12 |
| FR1597550A (en) | 1970-06-29 |
| NL6814260A (en) | 1969-04-09 |
| YU32939B (en) | 1975-12-31 |
| YU229968A (en) | 1975-06-30 |
| SE344463B (en) | 1972-04-17 |
| NL160555B (en) | 1979-06-15 |
| CH513185A (en) | 1971-09-30 |
| NO122019B (en) | 1971-05-10 |
| DE1670936C3 (en) | 1979-03-22 |
| DK128679B (en) | 1974-06-17 |
| DE1670936A1 (en) | 1971-02-25 |
| AT281837B (en) | 1970-06-10 |
| IL30714A0 (en) | 1968-12-26 |
| FI49722B (en) | 1975-06-02 |
| FR8124M (en) | 1970-08-03 |
| BE721725A (en) | 1969-04-02 |
| NL160555C (en) | 1979-11-15 |
| FI49722C (en) | 1975-09-10 |
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