ES354866A1 - Procedure for the obtaining of 2-aminomethyl-2,3-dihydro-benzofurans. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining 2-aminomethyl-2,3-dihydro-benzofurans, of general formula I **(See formula)** wherein R1 signifies an aromatic residue or an aromatic heterocyclic residue, each of the radicals alk1 and alk2 signifies alkylene and separating the nitrogen atoms by two carbon atoms, each of the symbols R2 and R3 signifying hydrogen or lower alkyl, and Ph represents a 1,2-phenylene residue, and its quaternary compounds, characterized in that a) the compounds of the formulas are condensed **(See formula)** wherein one of the symbols X and Y means an esterified hydroxy radical, capable of reaction or a bis-β-hydroxy-lower alkyl) -amino radical and the other the radical of formula **(See formula)** or a primary amino radical, in which X and Y contain only 2 nitrogen atoms together, or b) the compounds of the formulas are reacted **(See formula)** wherein each of the symbols means an esterified hydroxy radical capable of reaction, or c) is reduced in the compounds of formula **(See formula)** wherein each of the radicals alk3 and alk4 signifies lower alkylene or lower alkanoylene, and T represents lower alkylidene, 1-hydroxy-lower alkylidene or carbonyl, or its 2-dehydro-derivatives, containing at least one carbonyl radical in alk3, alk4 and T, a hydroxy-methylene group in T and/or a quaternary carbon atom in position 2, these groups to methylene or methylidene, and, if desired, a free compound obtained is transformed into its salts or quaternary compounds, or a obtained salt or a obtained quaternary compound is transformed into the free compound, and/or, if desired, a mixture of obtained isomers is separated into the different isomers, and/or a obtained compound is transformed into another compound according to the present invention. (Machine-translation by Google Translate, not legally binding)