GB876686A - Improvements in or relating to bicyclo (2,2,2) octane derivatives - Google Patents

Improvements in or relating to bicyclo (2,2,2) octane derivatives

Info

Publication number
GB876686A
GB876686A GB1979559A GB1979559A GB876686A GB 876686 A GB876686 A GB 876686A GB 1979559 A GB1979559 A GB 1979559A GB 1979559 A GB1979559 A GB 1979559A GB 876686 A GB876686 A GB 876686A
Authority
GB
United Kingdom
Prior art keywords
bicyclo
octano
disubstituted
compounds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1979559A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB876686A publication Critical patent/GB876686A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention comprises acid addition or mono or bis-methonium salts of compounds of the general formula <FORM:0876686/IV (b)/1> wherein A is a divalent saturated straight or branched chain aliphatic hydrocarbon radical containing 2-5 carbon atoms, the radicals R when individual, are the same or different and when linked together, form with the adjacent nitrogen atom a heterocyclic ring and B is a bicyclo [2,2,2] octane ring system which is unsaturated or saturated, unsubstituted or substituted by one or more alkyl, oxo, and/or hydroxyl groups or has a benzene ring fused on to one of its sides. The compounds of the invention may be prepared by condensing a bicyclo [2,2,2] octano-2,3-dicarboxylic anhydride with a N-disubstituted-aminoalkylamine, reducing the imide so formed and, if desired, reacting the 11-(o -disubstituted-aminoalkyl)-bicyclo [2,2,2] octano [2,3:31,41] pyrrolidine with an alkyl halide or treating the base with an acid.
GB1979559A 1958-06-09 1959-06-09 Improvements in or relating to bicyclo (2,2,2) octane derivatives Expired GB876686A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP1621058 1958-06-09
JP1620958 1958-06-09
JP1621158 1958-06-09
JP2974058 1958-10-16
JP2974158 1958-10-16
JP2995658 1958-10-19

Publications (1)

Publication Number Publication Date
GB876686A true GB876686A (en) 1961-09-06

Family

ID=27548637

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1979559A Expired GB876686A (en) 1958-06-09 1959-06-09 Improvements in or relating to bicyclo (2,2,2) octane derivatives

Country Status (4)

Country Link
CH (1) CH390915A (en)
DE (1) DE1179205B (en)
GB (1) GB876686A (en)
NL (3) NL6607984A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300381A (en) * 1964-01-28 1967-01-24 Rexall Drug Chemical Method of effecting diuretic therapy

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3584009A (en) * 1968-09-26 1971-06-08 Du Pont 2h-4,9-ethanobenzisoindolones and derivatives thereof as pharmaceutical agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300381A (en) * 1964-01-28 1967-01-24 Rexall Drug Chemical Method of effecting diuretic therapy

Also Published As

Publication number Publication date
NL6607985A (en) 1966-09-26
NL6607984A (en) 1966-09-26
DE1179205B (en) 1964-10-08
NL126393C (en)
CH390915A (en) 1965-04-30

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