ES352579A1 - Un procedimiento para la preparacion de un oxazol sustitui-do por monoarilo. - Google Patents
Un procedimiento para la preparacion de un oxazol sustitui-do por monoarilo.Info
- Publication number
- ES352579A1 ES352579A1 ES352579A ES352579A ES352579A1 ES 352579 A1 ES352579 A1 ES 352579A1 ES 352579 A ES352579 A ES 352579A ES 352579 A ES352579 A ES 352579A ES 352579 A1 ES352579 A1 ES 352579A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- give
- acids
- prepared
- oxazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XYVMOLOUBJBNBF-UHFFFAOYSA-N 3h-1,3-oxazol-2-one Chemical compound OC1=NC=CO1 XYVMOLOUBJBNBF-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- -1 haloalkylphenyl Chemical group 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 5
- 150000007513 acids Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- 101150047265 COR2 gene Proteins 0.000 abstract 2
- 101100467189 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) QCR2 gene Proteins 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- SUNMBRGCANLOEG-UHFFFAOYSA-N 1,3-dichloroacetone Chemical compound ClCC(=O)CCl SUNMBRGCANLOEG-UHFFFAOYSA-N 0.000 abstract 1
- NLLYDPLGYXCDPO-UHFFFAOYSA-N 2-(2-phenyl-1,3-oxazol-4-yl)acetonitrile Chemical compound N#CCC1=COC(C=2C=CC=CC=2)=N1 NLLYDPLGYXCDPO-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- ANSKJZIDWXDAJW-UHFFFAOYSA-N 4-(chloromethyl)-2-phenyl-1,3-oxazole Chemical compound ClCC1=COC(C=2C=CC=CC=2)=N1 ANSKJZIDWXDAJW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- MNWBNISUBARLIT-UHFFFAOYSA-N sodium cyanide Chemical compound [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2738267 | 1967-06-14 | ||
| GB3759867 | 1967-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES352579A1 true ES352579A1 (es) | 1970-01-01 |
Family
ID=26258780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES352579A Expired ES352579A1 (es) | 1967-06-14 | 1968-04-09 | Un procedimiento para la preparacion de un oxazol sustitui-do por monoarilo. |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4938268B1 (en, 2012) |
| BE (1) | BE713392A (en, 2012) |
| CH (1) | CH560204A5 (en, 2012) |
| DE (1) | DE1770177A1 (en, 2012) |
| DK (1) | DK137674B (en, 2012) |
| ES (1) | ES352579A1 (en, 2012) |
| FR (2) | FR8056M (en, 2012) |
| GB (1) | GB1226548A (en, 2012) |
| IE (1) | IE32086B1 (en, 2012) |
| IL (1) | IL29654A (en, 2012) |
| IT (1) | IT1053686B (en, 2012) |
| LU (1) | LU55869A1 (en, 2012) |
| NL (1) | NL6805103A (en, 2012) |
| PL (1) | PL71145B1 (en, 2012) |
| SE (1) | SE374745B (en, 2012) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794096A (fr) * | 1972-08-07 | 1973-05-16 | Lepetit Spa | Oxazoles 2,4,5-trisubstitues et leur preparation |
| JPS58183676A (ja) * | 1982-04-19 | 1983-10-26 | Takeda Chem Ind Ltd | オキサゾ−ル誘導体 |
| CA2396738C (en) * | 1990-11-30 | 2006-08-29 | Masatoshi Chihiro | Thiazole derivatives as active superoxide radical inhibitors |
| MY128323A (en) | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
-
1967
- 1967-06-14 GB GB2738267A patent/GB1226548A/en not_active Expired
-
1968
- 1968-03-18 IL IL2965468A patent/IL29654A/xx unknown
- 1968-03-29 IT IT1458968A patent/IT1053686B/it active
- 1968-04-06 JP JP2278168A patent/JPS4938268B1/ja active Pending
- 1968-04-08 PL PL12630768A patent/PL71145B1/pl unknown
- 1968-04-08 BE BE713392D patent/BE713392A/xx not_active IP Right Cessation
- 1968-04-09 ES ES352579A patent/ES352579A1/es not_active Expired
- 1968-04-10 NL NL6805103A patent/NL6805103A/xx unknown
- 1968-04-10 CH CH537068A patent/CH560204A5/xx not_active IP Right Cessation
- 1968-04-10 FR FR147664A patent/FR8056M/fr not_active Expired
- 1968-04-10 LU LU55869D patent/LU55869A1/xx unknown
- 1968-04-10 SE SE486968A patent/SE374745B/xx unknown
- 1968-04-10 DE DE19681770177 patent/DE1770177A1/de not_active Ceased
- 1968-04-10 DK DK162468A patent/DK137674B/da not_active IP Right Cessation
- 1968-04-10 FR FR1587052D patent/FR1587052A/fr not_active Expired
- 1968-05-17 IE IE59268A patent/IE32086B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE32086L (en) | 1968-12-14 |
| IL29654A (en) | 1974-05-16 |
| CH560204A5 (en, 2012) | 1975-03-27 |
| DK137674C (en, 2012) | 1978-09-25 |
| IE32086B1 (en) | 1973-04-04 |
| LU55869A1 (en, 2012) | 1968-07-09 |
| BE713392A (en, 2012) | 1968-10-08 |
| FR1587052A (en, 2012) | 1970-03-13 |
| PL71145B1 (en) | 1974-04-30 |
| FR8056M (en, 2012) | 1970-07-06 |
| DK137674B (da) | 1978-04-17 |
| DE1770177A1 (de) | 1972-03-16 |
| SE374745B (en, 2012) | 1975-03-17 |
| NL6805103A (en, 2012) | 1968-12-16 |
| JPS4938268B1 (en, 2012) | 1974-10-16 |
| GB1226548A (en, 2012) | 1971-03-31 |
| IT1053686B (it) | 1981-10-10 |
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