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Novartis AG
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JR Geigy AG
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Priority to ES349723ApriorityCriticalpatent/ES349723A1/en
Publication of ES349723A1publicationCriticalpatent/ES349723A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Procedure for the preparation of indole derivatives of the general formula **(See formula)** in which R means a lower alkyl group or a phenyl group, which may be substituted by lower alkyl or alkoxy groups, or a halogen atom up to atomic number 35, R1 and R2 signify, independently of each other, hydrogen, lower alkyl, alkoxy or alkanoyloxy groups, a phenylalkoxy group with at most 9 carbon atoms, fluorine, chlorine, bromine or hydroxy groups, or together signify the methylenedioxy group, A stands for an alkylene radical with no more than 4 carbon atoms, R3 and R4 each mean a lower alkyl group or as -NR3R4 a pyrrolidino, piperidino, hexamethyleneimino, morpholino, dialkylimorpholino lower group or a tetrahydropyridino group. as well as its pharmaceutically usable salts, characterized in that an indole derivative of the general formula **(See formula)** in which A, R, R3 and R4 have the significance indicated above, and R1'and/or R2' means a hydroxy group, is reacted with a corresponding alkylating agent or alkanoylating agent and, if desired, the compounds thus obtained of the general formula I are transformed into pharmaceutically usable salts. (Machine-translation by Google Translate, not legally binding)
ES349723A1968-01-241968-01-24Procedure for the preparation of indol derivatives. (Machine-translation by Google Translate, not legally binding)
ExpiredES349723A1
(en)
Procedure for preparing N-alcohilamino-alcohilic derivatives of espirotetralinosuccinimidas and their salts. (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding)