ES348773A1 - Benzenesulphonyl-ureas and process for preparing them - Google Patents
Benzenesulphonyl-ureas and process for preparing themInfo
- Publication number
- ES348773A1 ES348773A1 ES348773A ES348773A ES348773A1 ES 348773 A1 ES348773 A1 ES 348773A1 ES 348773 A ES348773 A ES 348773A ES 348773 A ES348773 A ES 348773A ES 348773 A1 ES348773 A1 ES 348773A1
- Authority
- ES
- Spain
- Prior art keywords
- ethyl
- chloro
- methoxy
- benzamido
- urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thermally Actuated Switches (AREA)
Abstract
Novel compounds I (including salts thereof) wherein Z signifies H, C 1-4 alkoxy, alkyloxy, methoxymethoxy or ethoxymethoxy and X signifies halogen, methyl, -CF 3 or methoxy, or, if Z is alkoxy or alkyloxy X may also signify H, are prepared utilizing standard methods. The preparation of the following intermediates is also described: N - [4 - (# - <3 - methylbenzamido> - ethyl) - benzenesulphonyl] - N1,N1 - diphenyl - urea and -N1 - cyclo - heptatrienylurea, 1 - [4 - (# - <2 - methoxy - 5 - chloro - benz - amido> - ethyl) - benzenesulphonyl] - 3 - cyclo - heptyl - parabanic acid, N - [4 - (# - <2 - meth - oxy - 5 - chloro - benzamido> - ethyl) - benzene - sulphonyl] - phenyl urethane, -N1 - methyl-urea, -N1-acetyl - urea, -N1-cycloheptyl - thiourea and the corresponding -N1-cycloheptyl - isourea methyl ether, -N1-cycloheptyl - isothiourea methyl ether, and -imino - dithiocarbonic acid (in the form of the potassium salt) and the dimethyl ester thereof, N,N1-bis-[4-(#-<2-methoxy - 5 - chloro - benzamido> - ethyl) - benzene - sulphonyl] - urea, 4 - [4 - (# - <2 - methoxy - 5 - chloro - benzamido > ethyl) - benzenesulphonyl] - cyclo - octanone - semicarbazone, 4 - (# - <2 - methoxy - 5 - chloro - benzamido> - ethyl) - ben - zenesulphonamide and the cycloheptylamine salt of N - [4 - (# - <2 - methoxy - 5 - chloro - benzamido> - ethyl - benzenesulphonyl] - N1- acetyl-urea. Pharmaceutical preparations showing hypoglycemic action contain as active ingredient compounds I administration may be orally, e.g. in the form of a tablet. Reference has been directed by the Comptroller to Specification 1,080,705.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0051164 | 1967-01-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES348773A1 true ES348773A1 (en) | 1969-11-01 |
Family
ID=7104389
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES348773A Expired ES348773A1 (en) | 1967-01-03 | 1967-12-29 | Benzenesulphonyl-ureas and process for preparing them |
| ES366601A Expired ES366601A1 (en) | 1967-01-03 | 1969-04-29 | Benzenesulphonyl-ureas and process for preparing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES366601A Expired ES366601A1 (en) | 1967-01-03 | 1969-04-29 | Benzenesulphonyl-ureas and process for preparing them |
Country Status (21)
| Country | Link |
|---|---|
| AT (1) | AT327935B (en) |
| BE (1) | BE708917A (en) |
| CH (7) | CH524579A (en) |
| CS (1) | CS161702B2 (en) |
| CY (1) | CY586A (en) |
| DE (1) | DE1618333C3 (en) |
| DK (2) | DK123865B (en) |
| ES (2) | ES348773A1 (en) |
| FI (1) | FI49157C (en) |
| FR (2) | FR1559029A (en) |
| GB (1) | GB1205322A (en) |
| IL (1) | IL29182A (en) |
| IS (1) | IS897B6 (en) |
| LU (1) | LU55140A1 (en) |
| MC (1) | MC698A1 (en) |
| MY (1) | MY7100110A (en) |
| NL (1) | NL6717808A (en) |
| NO (1) | NO123385B (en) |
| OA (1) | OA03383A (en) |
| SE (1) | SE339222B (en) |
| SU (4) | SU366605A3 (en) |
-
1967
- 1967-01-03 DE DE1618333A patent/DE1618333C3/en not_active Expired
- 1967-12-14 DK DK627167AA patent/DK123865B/en unknown
- 1967-12-18 IS IS1711A patent/IS897B6/en unknown
- 1967-12-20 MC MC740A patent/MC698A1/en unknown
- 1967-12-20 LU LU55140D patent/LU55140A1/xx unknown
- 1967-12-21 IL IL29182A patent/IL29182A/en unknown
- 1967-12-22 CH CH1805167A patent/CH524579A/en not_active IP Right Cessation
- 1967-12-22 CH CH548470A patent/CH567464A5/xx not_active IP Right Cessation
- 1967-12-22 CH CH548270A patent/CH566973A5/xx not_active IP Right Cessation
- 1967-12-22 CH CH548570A patent/CH566975A5/xx not_active IP Right Cessation
- 1967-12-22 CH CH548370A patent/CH566974A5/xx not_active IP Right Cessation
- 1967-12-28 OA OA53137A patent/OA03383A/en unknown
- 1967-12-28 NO NO171182A patent/NO123385B/no unknown
- 1967-12-29 ES ES348773A patent/ES348773A1/en not_active Expired
- 1967-12-29 NL NL6717808A patent/NL6717808A/xx unknown
- 1967-12-30 FI FI673527A patent/FI49157C/en active
-
1968
- 1968-01-02 FR FR1559029D patent/FR1559029A/fr not_active Expired
- 1968-01-02 AT AT968*BA patent/AT327935B/en not_active IP Right Cessation
- 1968-01-02 SU SU1207929A patent/SU366605A3/ru active
- 1968-01-02 SU SU1623403A patent/SU448641A3/en active
- 1968-01-02 SU SU1406180A patent/SU468402A3/en active
- 1968-01-02 CS CS30*YA patent/CS161702B2/cs unknown
- 1968-01-02 SU SU1406183A patent/SU453829A3/en active
- 1968-01-03 BE BE708917D patent/BE708917A/xx unknown
- 1968-01-03 SE SE00039/68A patent/SE339222B/xx unknown
- 1968-01-03 GB GB447/68A patent/GB1205322A/en not_active Expired
- 1968-03-29 FR FR146589A patent/FR8386M/fr not_active Expired
-
1969
- 1969-04-29 ES ES366601A patent/ES366601A1/en not_active Expired
- 1969-05-21 DK DK275669AA patent/DK122722B/en unknown
-
1971
- 1971-04-22 CY CY58671A patent/CY586A/en unknown
- 1971-12-30 MY MY110/71A patent/MY7100110A/en unknown
-
1974
- 1974-03-22 CH CH1805167A patent/CH593249A5/xx not_active IP Right Cessation
- 1974-12-22 CH CH554174A patent/CH592614A5/xx not_active IP Right Cessation
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