ES343610A1 - N-Aminoalkyl-N-Benzylamides - Google Patents
N-Aminoalkyl-N-BenzylamidesInfo
- Publication number
- ES343610A1 ES343610A1 ES343610A ES343610A ES343610A1 ES 343610 A1 ES343610 A1 ES 343610A1 ES 343610 A ES343610 A ES 343610A ES 343610 A ES343610 A ES 343610A ES 343610 A1 ES343610 A1 ES 343610A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- alpha
- phenylpiperidine
- benzylamine
- piperidyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Novel N,N-disubstituted amides of the formula wherein R 1 is C 1-6 alkyl, C 3-6 cycloalkyl, aryl or heterocyclic radical one of R 2 and R 3 is H, and the other is aryl and B is an unsubstituted or phenyl- and/or hydroxy - substituted nitrogenous heterocyclic radical connected to the adjacent CH group through a nitrogen atom, and acid addition salts thereof are prepared by acylating the corresponding amines of the formul[mu] C 6 H 5 CH 2 -NH-CH(R 2 )-CH 2 B or C 6 H 5 CH 2 -NH-CH 2 -CH(R 3 )-B N - (1 - Phenyl - 2 - (4 - phenyl - 1 - piperidyl)- ethyl]-benzylamine is prepared by reducing with LiAlH 4 1 - [[alpha] - (benzylamino) phenylacetyl] - 4- phenylpiperidine, obtained by reacting benzylamine with 1 - ([alpha] - chlorophenylacetyl)-4-phenylpiperidine, resulting from the treatment of [alpha]- chlorophenylacetyl chloride with 4-phenylpiperidine under Shotten-Baumann conditions. N - [1 - Phenyl - 2 - (4 - hydroxy - 4 - -phenyl - 1- piperidyl) ethylbenzylamine is made by reducing with L 1 AlH 4 1 - [[alpha] - (benzylamino) phenylacetyl] - 4 - hydroxy - 4 - phenylpiperidine obtained by refluxing 1-([alpha]-chlorophenylacetyl)-4- hydroxy-4-phenylpiperidine with benzylamine. N - [2 - Phenyl - 2 - (4 - phenyl - 1 - piperidyl) ethyl] benzylamine is obtained by reducing with LiAlH 4 N - benzyl - 2 - phenyl - 2 - (4 - phenyl - 1 - piperidyl) acetamide, obtained by refluxing 4- phenylpiperidine with N-benzyl-[alpha]-chloro - phenylacetamide, resulting from the reaction of [alpha]- chloro-phenylacetyl chloride with benzylamine. Pharmaceutical compositions having analgesic activity comprise as the active ingredients the above novel N,N-disubstituted amides or acid addition salts thereof together with pharmaceutically acceptable carriers or diluents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56904766A | 1966-08-01 | 1966-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES343610A1 true ES343610A1 (en) | 1968-12-01 |
Family
ID=24273875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES343610A Expired ES343610A1 (en) | 1966-08-01 | 1967-07-31 | N-Aminoalkyl-N-Benzylamides |
Country Status (6)
Country | Link |
---|---|
AT (1) | AT273969B (en) |
BE (1) | BE702091A (en) |
DE (1) | DE1695442A1 (en) |
ES (1) | ES343610A1 (en) |
GB (1) | GB1173833A (en) |
NL (1) | NL6710562A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE789025A (en) * | 1971-09-23 | 1973-03-20 | Allen & Hanburys Ltd | NEW ETHYLENE DIAMINES SUBSTITUTES |
HUT70741A (en) * | 1991-11-12 | 1995-10-30 | Pfizer | Acyclic ethylenediamine derivatives as substance p receptor antagonists |
US6403577B1 (en) | 1993-11-17 | 2002-06-11 | Eli Lilly And Company | Hexamethyleneiminyl tachykinin receptor antagonists |
-
1967
- 1967-07-17 AT AT667167A patent/AT273969B/en active
- 1967-07-25 GB GB3419167A patent/GB1173833A/en not_active Expired
- 1967-07-31 NL NL6710562A patent/NL6710562A/xx unknown
- 1967-07-31 ES ES343610A patent/ES343610A1/en not_active Expired
- 1967-07-31 BE BE702091D patent/BE702091A/xx unknown
- 1967-08-01 DE DE19671695442 patent/DE1695442A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AT273969B (en) | 1969-09-10 |
DE1695442A1 (en) | 1971-04-08 |
BE702091A (en) | 1968-01-02 |
GB1173833A (en) | 1969-12-10 |
NL6710562A (en) | 1968-02-02 |
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