ES342389A1 - Procedimiento para la produccion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas. - Google Patents

Procedimiento para la produccion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.

Info

Publication number
ES342389A1
ES342389A1 ES342389A ES342389A ES342389A1 ES 342389 A1 ES342389 A1 ES 342389A1 ES 342389 A ES342389 A ES 342389A ES 342389 A ES342389 A ES 342389A ES 342389 A1 ES342389 A1 ES 342389A1
Authority
ES
Spain
Prior art keywords
formula
compounds
appropriate
dihydroisoquinolines
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES342389A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES342389A1 publication Critical patent/ES342389A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la obtención de nuevas 1-(2-aminofenil)-1,2,3,4-tetrahidroisoquinoleínas de fórmula general I, **formula** donde R representa un átomo de hidrógeno, un grupo alcohilo inferior o un grupo aralcohilo, o un grupo acilo alifático, aromático o ralifático, R1 representa un grupo alcohilo inferior que contiene de 1 a 5 átomos de carbono, o un grupo bencilo o, junto con R1 y el átomo de carbono adyacente, forma un anillo cicloalifático, y R3 representa un átomo de hidrógeno o el grupo metilo así como de sus sales con ácidos inorgánicos u orgánicos, caracterizado por reducirse una 1-(2-amino-fenil)-3,4-dihidroisoquinoleína de la fórmula general II **formula** donde R y R3 tienen los significados indicados antes, por medio de hidrógeno catalíticamente activado, por medio de hidrógeno naciente o por medio de hidruros metálicos complejos, según métodos usuales, y convertir los compuestos así obtenidos si se desea, en sus sales de ácido con ácidos inorgánicos u orgánicos fisiológicamente tolerables, según métodos usuales.
ES342389A 1966-06-29 1967-06-27 Procedimiento para la produccion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas. Expired ES342389A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DET0031483 1966-06-29

Publications (1)

Publication Number Publication Date
ES342389A1 true ES342389A1 (es) 1968-09-16

Family

ID=7556348

Family Applications (4)

Application Number Title Priority Date Filing Date
ES342391A Expired ES342391A1 (es) 1966-06-29 1967-06-27 Procedimiento para la obtencion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.
ES342392A Expired ES342392A1 (es) 1966-06-29 1967-06-27 Procedimiento para la obtencion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.
ES342390A Expired ES342390A1 (es) 1966-06-29 1967-06-27 Procedimiento para la obtencion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.
ES342389A Expired ES342389A1 (es) 1966-06-29 1967-06-27 Procedimiento para la produccion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES342391A Expired ES342391A1 (es) 1966-06-29 1967-06-27 Procedimiento para la obtencion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.
ES342392A Expired ES342392A1 (es) 1966-06-29 1967-06-27 Procedimiento para la obtencion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.
ES342390A Expired ES342390A1 (es) 1966-06-29 1967-06-27 Procedimiento para la obtencion de nuevas 1 - (2-aminofe- nil)-1,2,3,4-tetrahidroisoquinoleinas.

Country Status (10)

Country Link
BE (1) BE700693A (es)
CH (1) CH488700A (es)
DE (1) DE1620554A1 (es)
DK (1) DK122077B (es)
ES (4) ES342391A1 (es)
FR (1) FR7511M (es)
GB (1) GB1176804A (es)
IL (1) IL28214A (es)
NL (2) NL6708984A (es)
SE (1) SE328884B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930703259A (ko) * 1990-12-17 1993-11-29 알베르투스 빌헬무스 요아네스 쩨스트라텐 살균성 이소퀴놀린 유도체

Also Published As

Publication number Publication date
NL129427C (es)
GB1176804A (en) 1970-01-07
BE700693A (es) 1967-12-29
ES342392A1 (es) 1968-09-16
SE328884B (es) 1970-09-28
IL28214A (en) 1971-03-24
FR7511M (es) 1969-12-15
NL6708984A (es) 1968-01-02
ES342390A1 (es) 1968-09-16
DK122077B (da) 1972-01-17
DE1620554A1 (de) 1970-04-30
ES342391A1 (es) 1968-09-16
CH488700A (de) 1970-04-15

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