ES335565A1 - Un procedimiento para preparar un medicamento con actividadantitusigena. - Google Patents
Un procedimiento para preparar un medicamento con actividadantitusigena.Info
- Publication number
- ES335565A1 ES335565A1 ES335565A ES335565A ES335565A1 ES 335565 A1 ES335565 A1 ES 335565A1 ES 335565 A ES335565 A ES 335565A ES 335565 A ES335565 A ES 335565A ES 335565 A1 ES335565 A1 ES 335565A1
- Authority
- ES
- Spain
- Prior art keywords
- benzyl alcohol
- hard candy
- paste
- dextromethorphan
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 title abstract 6
- 235000009508 confectionery Nutrition 0.000 title abstract 3
- 239000007937 lozenge Substances 0.000 title abstract 3
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 title abstract 2
- 235000019445 benzyl alcohol Nutrition 0.000 title abstract 2
- 229960001985 dextromethorphan Drugs 0.000 title abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- QXQAPNSHUJORMC-UHFFFAOYSA-N 1-chloro-4-propylbenzene Chemical compound CCCC1=CC=C(Cl)C=C1 QXQAPNSHUJORMC-UHFFFAOYSA-N 0.000 abstract 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- 239000005995 Aluminium silicate Substances 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000004150 EU approved colour Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Natural products OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 abstract 1
- 229910000323 aluminium silicate Inorganic materials 0.000 abstract 1
- 235000012211 aluminium silicate Nutrition 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 229960005274 benzocaine Drugs 0.000 abstract 1
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- 229960002228 diperodon Drugs 0.000 abstract 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- OWULVAZDMWJBLB-UHFFFAOYSA-N hydron;[2-(phenylcarbamoyloxy)-3-piperidin-1-ylpropyl] n-phenylcarbamate;chloride Chemical compound Cl.C1CCCCN1CC(OC(=O)NC=1C=CC=CC=1)COC(=O)NC1=CC=CC=C1 OWULVAZDMWJBLB-UHFFFAOYSA-N 0.000 abstract 1
- 229960005015 local anesthetics Drugs 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical group O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52036966A | 1966-01-13 | 1966-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES335565A1 true ES335565A1 (es) | 1968-03-16 |
Family
ID=24072303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES335565A Expired ES335565A1 (es) | 1966-01-13 | 1967-01-12 | Un procedimiento para preparar un medicamento con actividadantitusigena. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3427379A (en, 2012) |
| BE (1) | BE692250A (en, 2012) |
| DE (1) | DE1617515A1 (en, 2012) |
| DK (1) | DK118301B (en, 2012) |
| ES (1) | ES335565A1 (en, 2012) |
| FR (1) | FR6250M (en, 2012) |
| GB (1) | GB1111173A (en, 2012) |
| IL (1) | IL27056A (en, 2012) |
| NL (1) | NL6700549A (en, 2012) |
| SE (1) | SE338401B (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903284A (en) * | 1971-10-06 | 1975-09-02 | Denson Fred L | Composition containing iminoethanophenanthrene derivatives and method of use |
| US4316888A (en) * | 1980-04-15 | 1982-02-23 | Nelson Research & Development Co. | Method and composition of reducing pain |
| US4971798A (en) * | 1989-11-30 | 1990-11-20 | Miles Inc. | Hard confections containing hydrogenated isomaltulose and medicinally active ingredient |
| CH685978A5 (fr) * | 1991-01-30 | 1995-11-30 | Wellcome Found | Comprimes dispersables dans l'eau. |
| US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5302394A (en) * | 1992-07-14 | 1994-04-12 | Mcneil-Ppc, Inc. | Dextromethorphan continuous lozenge manufacturing process |
| GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5622980A (en) * | 1993-08-17 | 1997-04-22 | Applied Analytical Industries, Inc. | Oral compositions of H2-antagonists |
| US8425892B2 (en) | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| US20050238695A1 (en) * | 2004-04-27 | 2005-10-27 | Atma Chaudhari | Lozenge for delivery of dextromethorphan |
| US8668902B2 (en) * | 2006-06-08 | 2014-03-11 | Vapor Shield, Inc. | Composition with activated carbon in oral treatment |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3123528A (en) * | 1964-03-03 | New therapeutic compositions | ||
| US2841528A (en) * | 1954-09-21 | 1958-07-01 | Collett & Co As | Method of making fused tablets |
| US2963404A (en) * | 1958-09-05 | 1960-12-06 | Pfizer & Co C | Tannate candy making, and product |
| US3012893A (en) * | 1959-01-06 | 1961-12-12 | Gen Foods Corp | Gasified confection and method of making the same |
| US3085942A (en) * | 1960-12-28 | 1963-04-16 | Hoffmann La Roche | Antitussive compositions and preparation |
| US3140978A (en) * | 1961-11-02 | 1964-07-14 | Hoffmann La Roche | Pharmaceutical composition containing complex magnesium aluminum silicate |
| US3248290A (en) * | 1962-08-09 | 1966-04-26 | Hoffmann La Roche | Antitussive compositions |
| US3282789A (en) * | 1963-05-17 | 1966-11-01 | Neisler Lab Inc | Stable liquid colloidal tannate compositions |
| US3341414A (en) * | 1964-08-27 | 1967-09-12 | Merck & Co Inc | N-cyclohexylsulfamate solubilized medication |
-
1966
- 1966-01-13 US US520369A patent/US3427379A/en not_active Expired - Lifetime
- 1966-12-14 IL IL27056A patent/IL27056A/xx unknown
- 1966-12-20 DE DE19661617515 patent/DE1617515A1/de active Pending
-
1967
- 1967-01-06 BE BE692250D patent/BE692250A/xx unknown
- 1967-01-09 SE SE00293/67A patent/SE338401B/xx unknown
- 1967-01-11 FR FR90613A patent/FR6250M/fr not_active Expired
- 1967-01-11 GB GB1578/67A patent/GB1111173A/en not_active Expired
- 1967-01-12 ES ES335565A patent/ES335565A1/es not_active Expired
- 1967-01-13 NL NL6700549A patent/NL6700549A/xx unknown
- 1967-01-13 DK DK22367AA patent/DK118301B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL6700549A (en, 2012) | 1967-07-14 |
| FR6250M (en, 2012) | 1968-08-19 |
| SE338401B (en, 2012) | 1971-09-06 |
| DE1617515A1 (de) | 1971-03-18 |
| IL27056A (en) | 1970-07-19 |
| BE692250A (en, 2012) | 1967-07-06 |
| DK118301B (da) | 1970-08-03 |
| GB1111173A (en) | 1968-04-24 |
| US3427379A (en) | 1969-02-11 |
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