ES334305A1 - Procedimiento para la preparacion de n-hidroxiamidas deri- vadas de acidos para alquiloxiarilaceticos. - Google Patents
Procedimiento para la preparacion de n-hidroxiamidas deri- vadas de acidos para alquiloxiarilaceticos.Info
- Publication number
- ES334305A1 ES334305A1 ES334305A ES334305A ES334305A1 ES 334305 A1 ES334305 A1 ES 334305A1 ES 334305 A ES334305 A ES 334305A ES 334305 A ES334305 A ES 334305A ES 334305 A1 ES334305 A1 ES 334305A1
- Authority
- ES
- Spain
- Prior art keywords
- prepared
- chloro
- formula
- alkali metal
- dibromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 6
- 150000001340 alkali metals Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- -1 alkali metal salts Chemical class 0.000 abstract 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000003863 ammonium salts Chemical class 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 4
- 125000001153 fluoro group Chemical group F* 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- RGHHSNMVTDWUBI-UHFFFAOYSA-N 4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1 RGHHSNMVTDWUBI-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 2
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- ZNWPTJSBHHIXLJ-UHFFFAOYSA-N 1-(3,5-dibromo-4-hydroxyphenyl)ethanone Chemical compound CC(=O)C1=CC(Br)=C(O)C(Br)=C1 ZNWPTJSBHHIXLJ-UHFFFAOYSA-N 0.000 abstract 1
- SKTHXBXIQFAXPC-UHFFFAOYSA-N 2-(4-butoxyphenyl)acetonitrile Chemical compound CCCCOC1=CC=C(CC#N)C=C1 SKTHXBXIQFAXPC-UHFFFAOYSA-N 0.000 abstract 1
- XHWMNHADTZZHGI-UHFFFAOYSA-N 4-butoxybenzaldehyde Chemical compound CCCCOC1=CC=C(C=O)C=C1 XHWMNHADTZZHGI-UHFFFAOYSA-N 0.000 abstract 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 125000004350 aryl cycloalkyl group Chemical group 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Substances ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- STTILPXFYKXZCN-UHFFFAOYSA-N ethyl 2-(3,5-dibromo-4-butoxyphenyl)acetate Chemical compound BrC=1C=C(C=C(C1OCCCC)Br)CC(=O)OCC STTILPXFYKXZCN-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- LDHPBZITZBTSBT-UHFFFAOYSA-N methyl 2-(4-butoxyphenyl)-2-hydroxyacetate Chemical compound C(CCC)OC1=CC=C(C(C(=O)OC)O)C=C1 LDHPBZITZBTSBT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE21357 | 1965-12-09 | ||
| BE35540 | 1966-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES334305A1 true ES334305A1 (es) | 1968-02-01 |
Family
ID=25647038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES334305A Expired ES334305A1 (es) | 1965-12-09 | 1966-12-07 | Procedimiento para la preparacion de n-hidroxiamidas deri- vadas de acidos para alquiloxiarilaceticos. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3586713A (en, 2012) |
| AT (1) | AT273920B (en, 2012) |
| BE (1) | BE689347A (en, 2012) |
| CH (1) | CH475201A (en, 2012) |
| DE (1) | DE1543784A1 (en, 2012) |
| ES (1) | ES334305A1 (en, 2012) |
| FR (2) | FR6048M (en, 2012) |
| GB (1) | GB1166818A (en, 2012) |
| NL (1) | NL6617354A (en, 2012) |
| OA (1) | OA02280A (en, 2012) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3890377A (en) * | 1968-08-15 | 1975-06-17 | Lilly Co Eli | 3-Substituted phenylalkanohydroxamic acids |
| US3689547A (en) * | 1970-03-12 | 1972-09-05 | Nippon Soda Co | Benzohydroxamates |
| US4173577A (en) * | 1970-09-09 | 1979-11-06 | Ciba-Geigy Corporation | Phenylacetohydroxamic acids |
| US3978116A (en) * | 1971-11-04 | 1976-08-31 | Syntex Corporation | 2-naphthyl acetic acid derivatives and compositions and methods thereof |
| JPS522899B2 (en, 2012) * | 1972-07-04 | 1977-01-25 | ||
| US4082707A (en) * | 1973-01-08 | 1978-04-04 | Societa Italo-Britannica L. Manetti-H. Roberts & Co. | 2-(4-isobutylphenyl)-propiohydroxamic acid and a procedure for its preparation |
| NL7614113A (nl) * | 1976-12-18 | 1978-06-20 | Akzo Nv | Hydroxamzuren. |
| US4173652A (en) * | 1976-12-18 | 1979-11-06 | Akzona Incorporated | Pharmaceutical hydroxamic acid compositions and uses thereof |
| US4134890A (en) * | 1977-03-11 | 1979-01-16 | G. D. Searle & Co. | 2-Aryl-2-[ω-(diisopropylamino)alkyl]-ω-(azabicycloalkyl)alkanamides |
| US4217306A (en) | 1978-05-01 | 1980-08-12 | G. D. Searle & Co. | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]-acetamides |
| JPS56108752A (en) * | 1980-01-28 | 1981-08-28 | Sumitomo Chem Co Ltd | N-substituted benzylphenylacetamide derivative, its preparation and herbicide containing the same as active constituent |
| DE3326164A1 (de) * | 1983-07-20 | 1985-01-31 | Klinge Pharma GmbH, 8000 München | Neue p-oxibenzoesaeure-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
| US4639524A (en) * | 1984-07-09 | 1987-01-27 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
| GB8531839D0 (en) * | 1985-12-30 | 1986-02-05 | Wellcome Found | Aryl derivatives |
| US4792560A (en) * | 1985-04-03 | 1988-12-20 | Rorer Pharmaceutical Corporation | Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways |
| US5015765A (en) * | 1988-03-24 | 1991-05-14 | Fmc Corporation | Process for isolating hydroxamic acids |
| GB8813714D0 (en) * | 1988-06-09 | 1988-07-13 | Glaxo Group Ltd | Chemical compounds |
| DE3913682A1 (de) * | 1989-04-26 | 1990-10-31 | Bayer Ag | 3-aryl-pyrrolidin-2,4-dione |
| US5099060A (en) * | 1990-06-12 | 1992-03-24 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| US5216115A (en) * | 1990-06-12 | 1993-06-01 | Rutgers, The State University Of New Jersey | Polyarylate containing derivatives of the natural amino acid L-tyrosine |
| GB9927056D0 (en) * | 1999-11-17 | 2000-01-12 | Karobio Ab | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders |
| EP1383729A4 (en) * | 2001-04-05 | 2006-04-19 | Smithkline Beecham Corp | DEFORMYLASE PEPTIDE INHIBITORS |
| GB0406378D0 (en) * | 2004-03-22 | 2004-04-21 | Karobio Ab | Novel pharmaceutical compositions |
-
1966
- 1966-11-07 BE BE689347D patent/BE689347A/xx unknown
- 1966-11-25 GB GB52909/66A patent/GB1166818A/en not_active Expired
- 1966-11-29 DE DE19661543784 patent/DE1543784A1/de active Pending
- 1966-12-01 OA OA52674A patent/OA02280A/xx unknown
- 1966-12-02 AT AT1117066A patent/AT273920B/de active
- 1966-12-07 ES ES334305A patent/ES334305A1/es not_active Expired
- 1966-12-07 FR FR86528A patent/FR6048M/fr not_active Expired
- 1966-12-07 FR FR86529A patent/FR1503394A/fr not_active Expired
- 1966-12-08 CH CH1749266A patent/CH475201A/fr not_active IP Right Cessation
- 1966-12-09 NL NL6617354A patent/NL6617354A/xx unknown
-
1968
- 1968-11-05 US US773623A patent/US3586713A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR1503394A (fr) | 1967-11-24 |
| DE1543784A1 (de) | 1972-03-09 |
| NL6617354A (en, 2012) | 1967-06-12 |
| OA02280A (fr) | 1970-05-05 |
| BE689347A (en, 2012) | 1967-04-14 |
| US3586713A (en) | 1971-06-22 |
| CH475201A (fr) | 1969-07-15 |
| FR6048M (en, 2012) | 1968-07-11 |
| GB1166818A (en) | 1969-10-08 |
| AT273920B (de) | 1969-08-25 |
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