ES332515A1 - Procedure for the preparation of imidazole derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of imidazole derivatives of the general formula I, ** (See formula) ** and its tautomeric forms, in which R1 means an alkyl group of lower molecular weight, a lower molecular weight alkenyl group, a cycloalkyl group, a lower molecular weight cycloalkyl-alkyl group, a lower molecular weight dialkylamino-alkyl group, an alkoxy-alkyl group of molecular weight lower, a monocarbocyclic aryl group, a monocarbocyclic aralkyl group of lower molecular weight, a pyridyl group, a monocarbocyclic aryl group, substituted one, two or three times, independently of each other, by lower molecular weight alkyl groups, by weight alkoxy groups lower molecular weight, by halogen atoms or by trifluoromethyl groups, and R2 means a hydrogen atom or an alkyl group of lower molecular weight, and R3 means a hydrogen atom, a monocarbocyclic aryl group, substituted one, two or three times, independently of one another, by lower molecular weight alkyl groups, by lower molecular weight alkoxy groups, by trifluoromethyl groups or by halogen atoms , or in case R1 means a peridyl group, it can also be a lower molecular weight alkyl group, characterized in that it is reacted in a polar solvent, formaldehyde, a primary amine of the general formula II ** (See formula) ** in which R1 has the significance indicated above, and an alpha-isonitrosoketone of the general formula III ** (See formula) ** and its tautomeric forms in which R2 and R3 have the significance indicated above, and the reaction mixture is treated with a reagent, which yields sulfhydrate ions. (Machine-translation by Google Translate, not legally binding)