ES327777A1 - Procedure for the obtaining of derivatives of i-isopropilamino-2-hidroxi-propane. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

"Process for obtaining derivatives of 1-isopropylamino-2-hydroxy-propane", of general formula ** (See formula) ** wherein alk means an alkylene moiety and R an unsaturated aliphatic hydrocarbon moiety, with alk and R together having at least 4 carbon atoms, characterized in that a 3- [o- (R-alk-O) -phenoxy] -1 , 2-dihydroxy-propane or 3- [o- (R-alk-O) -phenoxy] -1,2-epoxy-propane, esterified in a reactive form at the hydroxyl radical in position 1, where alk and R have the meanings indicated above, is reacted with isopropylamine, or at the amino radical of 1-amino-2-hydroxy-3- [o- (R-alk-O) -phenoxy] -propane, where alk and R have the meanings indicated above, the isopropyl radical or o- (R-alk-O) -phenol is introduced, in which alk and R have the meanings indicated above, is reacted with a 3-isopropylamino-1,2-dihydroxy- propane esterified in a form capable of reaction at the hydroxyl radical in the 1-position, or with 3-isopropylamino-1,2-epoxy-propane, or in a 1-isopropylamino-2-hydroxy-3- [o- (R-alk -O) -phenoxy] -propane, in which alk and R have the meanings above, which show in the nitrogen atom and/or in the 2-hydroxy radical a dissociable moiety by hydrolysis or hydrogenolysis, this is dissociated, or the 1-isopropylamino-2-oxo-3- [o- (R-) alk-O) -phenoxy] -propanes, in which alk and R have the indicated meanings, are reduced to carbinoles, or a compound of formula ** (See formula) ** in which R and alk have the meanings indicated above and Y is a rest transformable by reduction of a double bond C-N in the radical of formula ** (See formula) ** is reduced. (Machine-translation by Google Translate, not legally binding)